grant
Mechanism of Chemotherapy Induced Microvascular Dysfunction in Cancer Survivors
Organization MEDICAL COLLEGE OF WISCONSINLocation MILWAUKEE, UNITED STATESPosted 1 Apr 2024Deadline 31 Mar 2029
NIHUS FederalResearch GrantFY202514-HydroxydaunomycinActive OxygenAcuteAdriamycineAnthracyclineAnti-ERB-2Anti-HER2/c-erbB2 Monoclonal AntibodyAnti-c-ERB-2Anti-c-erbB2 Monoclonal AntibodyAnti-erbB-2Anti-erbB2 Monoclonal AntibodyAnti-p185-HER2BioavailabilityBiological AvailabilityBlood VesselsBlood flowBreast CancerBreast Cancer survivorCancer PatientCancer SurvivorCancer SurvivorshipCancer TreatmentCancerousCardiacCardiac DiseasesCardiac DisordersCardiac Failure CongestiveCardiac Muscle CellsCardiac MyocytesCardiac ToxicityCardiocyteCardiotoxicCardiotoxicityCardiovascularCardiovascular Body SystemCardiovascular DiseasesCardiovascular Organ SystemCardiovascular PathologyCardiovascular systemCause of DeathCell BodyCell Communication and SignalingCell Growth in NumberCell MultiplicationCell ProliferationCell SignalingCell SurvivalCell ViabilityCellsCellular ProliferationCessation of lifeClinicalCombination Drug TherapyCongestive Heart FailureCoronaryCoronary ArteriosclerosisCoronary Artery DiseaseCoronary Artery DisorderCoronary AtherosclerosisCoronary VesselsDNA DamageDNA InjuryDataDeathDevelopmentDoxorubicinDoxorubicinaDrugsDysfunctionEFRACERBB2ERBB2 geneEST2Ejection FractionEndogenous Nitrate VasodilatorEndothelial CellsEndotheliumEndothelium-Derived Nitric OxideEventExposure toFree RadicalsFunctional disorderGoalsHER -2HER-2HER2HER2 GenesHER2 Monoclonal AntibodyHER2/neuHeartHeart DecompensationHeart DiseasesHeart Muscle CellsHeart VascularHeart failureHeart myocyteHerceptinHumanHydroxyl DaunorubicinHydroxyldaunorubicinHypertensionInflammatory ResponseInjuryIntracellular Communication and SignalingLinkLongitudinal StudiesMalignant Breast NeoplasmMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMediatingMedicationMetastasisMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic TumorMicrocirculationMicrovascular DysfunctionMitochondriaMitochondrial DNAMoAb HER2Modern ManMononitrogen MonoxideMorbidityMorbidity - disease rateMuscle CellsMyocardialMyocardial depressionMyocardial dysfunctionMyocardiumMyocytesNEU OncogeneNEU proteinNeoplasm MetastasisNitric OxideNitrogen MonoxideNitrogen ProtoxideNuclearOncogene ErbB2OncologyOncology CancerOrganOutcomeOxygen RadicalsPathologyPathway interactionsPatientsPerfusionPharmaceutical PreparationsPhysiologicPhysiologic AvailabilityPhysiologicalPhysiopathologyPlayPolychemotherapyPredispositionPro-OxidantsProductionReactive Oxygen SpeciesReportingResearchRiskRodentRodent ModelRodentiaRodents MammalsRoleSecondary NeoplasmSecondary TumorSignal TransductionSignal Transduction SystemsSignalingSurvivorsSusceptibilityTCS1TERT geneTKR1TLR9 geneTLR9 proteinTLR9 receptorTelomeraseTelomere Reverse TranscriptaseTestingToxic effectToxicitiesTrastuzumabTumor BurdenTumor LoadVascular EndotheliumVascular Hypertensive DiseaseVascular Hypertensive DisorderVasodilatationVasodilationVasorelaxationWomanWork LoadWorkloadadverse consequenceadverse outcomeanti-cancer therapyatherosclerotic coronary diseasebiological signal transductionbreast cancer diagnosisc-erb-2 Monoclonal Antibodyc-erbB-2c-erbB-2 Genesc-erbB-2 Proto-Oncogenescancer metastasiscancer therapycancer-directed therapycardiac dysfunctioncardiac failurecardiac functioncardiac musclecardiomyocytecardiovascular disorderchemotherapychronic heart failurecirculatory systemcombination chemotherapycombination pharmacotherapycoronary arterial diseasedevelopmentaldisease modeldisorder modeldrug/agentendothelial cell derived relaxing factorendothelial dysfunctionerbB-2 Genesexpectationexperiencefunction of the heartheart disorderheart dysfunctionheart functionheart muscleherstatinhigh blood pressurehyperpiesiahyperpiesishypertensive diseasehypertensive disorderimprovedinjurieslong-term studylongitudinal outcome studiesmalignant breast tumormicrovascular complicationsmicrovascular diseasemitochondrialmitochondrial dysfunctionmortalitymtDNAneu GenespathophysiologypathwaypreservationpressurepreventpreventingrepairrepairedrestorationrhuMAb HER2small vessel diseasesocial roletelomerase catalytic subunittoll-like receptor 9tumortumor cell metastasisvascularvascular endothelial dysfunction
Description preview
Project Abstract
Every year 255,000 new cases of breast cancer are diagnosed amounting to well over 4,000 deaths
occurring per year in U. S alone. With the use of anthracycline-based polychemotherapy (including doxorubicin),
the reduction in annual deaths from breast cancer is approximately 38% for women under 40. Systemic
Chemotherapy (CTx)…
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