grant
Mechanism For Merkel Cell Polyomavirus Persistence
Organization UNIVERSITY OF PITTSBURGH AT PITTSBURGHLocation PITTSBURGH, UNITED STATESPosted 10 Jan 2024Deadline 30 Nov 2028
NIHUS FederalResearch GrantFY20250-11 years oldAssayAutomobile DrivingB blood cellsB cellB cellsB-CellsB-LymphocytesB-cellBasal Transcription FactorBasal transcription factor genesBindingBinding ProteinsBinding SitesBioassayBiological AssayCRISPR editing screenCRISPR libraryCRISPR screenCRISPR-based libraryCRISPR-based screenCRISPR/Cas9 libraryCRISPR/Cas9 screenCancersCell BodyCell CycleCell Cycle StageCell Division CycleCellsChildChild YouthChildren (0-21)ChronicClustered Regularly Interspaced Short Palindromic Repeats libraryCombining SiteCutaneous Neuroendocrine CarcinomaDNADNA HelicasesDNA IntegrationDNA ReplicationDNA Replication InitiationDNA SynthesisDNA Tumor VirusesDNA Unwinding ProteinsDNA biosynthesisDNA mutationDNA unwinding enzymeDeoxyribonucleic AcidDiseaseDisorderE3 LigaseE3 Ubiquitin LigaseEarly Gene TranscriptionsElementsEnsureEpisomeEquilibriumExpression SignatureF BoxF Box DomainFeedbackGene Expression ProfileGene TranscriptionGeneral PopulationGeneral PublicGeneral Transcription Factor GeneGeneral Transcription FactorsGenetic ChangeGenetic TranscriptionGenetic defectGenetic mutationGenomeHerpesviridaeHerpesvirusesHumanIatrogenesisImmuneImmune SurveillanceImmune systemImmunesImmunocompromisedImmunocompromised HostImmunocompromised PatientImmunologic SurveillanceImmunosuppressed HostImmunosuppressionImmunosuppression EffectImmunosuppressive EffectImmunosurveillanceIn SituIndividualInfectionInterruptionKineticsKnock-outKnockoutLaboratoriesLarge T AntigenLate Gene TranscriptionsLife CycleLife Cycle StagesLigand Binding ProteinLigand Binding Protein GeneLong-term infectionLyticMalignant NeoplasmsMalignant Skin NeoplasmMalignant TumorMapsMeasurementMediatingMerkel Cell TumorMerkel CellsMerkel cell cancerMerkel cell carcinomaMerkel's ReceptorMicroRNAsModern ManMolecularMolecular InteractionMonitorMutationNeuroendocrine Carcinoma of the SkinOncogene ProductsOncogene ProteinsOncoproteinsPatientsPersonsPolyomaPolyoma VirusesPolyomavirusPolyomavirus InfectionsPredispositionPreventative measurePreventive measureProtein BindingProteinsRNA ExpressionReactive SiteRegulationReplication InitiationReporterResearchRetroviridaeRetrovirusesRoleSiteSkin CancerSusceptibilitySystemTherapeuticTrabecular Skin CarcinomaTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTranscriptional ControlTranscriptional RegulationTransmissionUbiquitin Protein LigaseUbiquitin-Protein Ligase ComplexesUbiquitin-Protein Ligase E3ViralViral DiseasesViral GenomeViral LatencyVirusVirus ActivationVirus DiseasesVirus InductionVirus LatencyVirus ReplicationVirus-RetrovirusVisualizationadult youthbalancebalance functionbound proteinchronic infectionclustered regularly interspaced short palindromic repeats screencombinatorialdrivinggene expression patterngene expression signaturegenome mutationhelicaseherpes virusiatrogeniciatrogenicallyiatrogenicityimmune clearanceimmune eliminationimmune suppressionimmune suppressive activityimmune suppressive functionimmunosuppressed patientimmunosuppressive activityimmunosuppressive functionimmunosuppressive responsekidsknockout genelatency/reactivationlife courselive cell imagelive cell imaginglive cellular imagelive cellular imagingmalignancymalignant skin tumormiRNAmutantneoplasm/cancernew technologynovelnovel technologiespersistent infectionpromoterpromotorreactivation from latencyrecruitscreeningscreeningssingle cell technologysingle moleculesocial roletargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttranscription factortranscriptional profiletranscriptional signaturetransmission processubiquitin-protein ligaseviral DNAviral activationviral inductionviral infectionviral multiplicationviral replicationviral transmissionvirologyvirus DNAvirus genomevirus infectionvirus multiplicationvirus transmissionvirus-induced diseaseyoung adultyoung adult ageyoung adulthoodyoungster
Description preview
ABSTRACT
A fundamental question in cancer virology is, how do some viruses persist as chronic viral infections that can
lead to cancer? Virus latency–in which the virus does not replicate independently of the host cell or produce
active viral progeny–is required for long term viral escape from immune surveillance. This leads to prolonged…
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