grant
Mechanical Load Effects on Cardiac Function and Heart Diseases
Organization UNIVERSITY OF CALIFORNIA AT DAVISLocation DAVIS, UNITED STATESPosted 1 Mar 2023Deadline 28 Feb 2030
NIHUS FederalResearch GrantFY2025AffectArrhythmiaBiologyCardiacCardiac ArrhythmiaCardiac DiseasesCardiac DisordersCardiac Muscle CellsCardiac MyocytesCardiac OutputCardiocyteCell BodyCell Communication and SignalingCell SignalingCellsCellular MechanotransductionChemistryCirculationContracting OpportunitiesContractsCouplingDiastolic heart failureDiseaseDisorderFeedbackGelGoalsHF with preserved ejection fractionHFpEFHealthHeartHeart ArrhythmiasHeart DiseasesHeart Muscle CellsHeart failureHeart myocyteHistoryHypertensionIntracellular Communication and SignalingKnowledgeMechanical Signal TransductionMechanical StressMechanosensory TransductionMethodsModelingMolecularMolecular TargetMyocardial depressionMyocardial dysfunctionMyocardiumOutcomeOutcomes ResearchPathologicPathway interactionsPhysicsPumpRecording of previous eventsResearchSTEM researchSignal TransductionSignal Transduction SystemsSignalingTechnologyTherapeuticVascular Hypertensive DiseaseVascular Hypertensive DisorderWorkbiological signal transductionblood pumpcardiac dysfunctioncardiac failurecardiac functioncardiac musclecardiomyocytedesigndesigningdynamic systemdynamical systemexperimentexperimental researchexperimental studyexperimentsfunction of the heartheart disorderheart dysfunctionheart failure with preserved ejection fractionheart failure with preserved systolic functionheart functionheart muscleheart outputhigh blood pressurehistorieshyperpiesiahyperpiesishypertensive diseasehypertensive disorderinnovateinnovationinnovativeinnovative technologiesinterdisciplinary approachmechanical loadmechanosensingmechanotransductionmultidisciplinary approachnew drug treatmentsnew drugsnew pharmacological therapeuticnew technologynew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeuticsnew therapynew therapy approachesnew treatment approachnew treatment strategynext generation therapeuticsnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel technologiesnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeuticsnovel therapynovel therapy approachpathwaypreserved ejection fraction heart failureresponsescience, technology, engineering and math researchscience, technology, engineering and mathematics research
Description preview
Significance: In every heartbeat, cardiac muscle cells generate contractile force to pump blood into circulation
against a mechanical load. Cardiomyocytes also sense load changes and adjust the contractility to maintain
cardiac output. Excessive overload in pathological conditions leads to heart diseases such as arrhythmias and
heart failure.…
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