grant
Measuring the Impact of the Value Flower and Unobserved Heterogeneity on the Cost Effectiveness and Use of Novel Treatments for Alzheimer's Disease and Related Dementias
Organization VIRGINIA COMMONWEALTH UNIVERSITYLocation RICHMOND, UNITED STATESPosted 15 Jun 2023Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY2025AD dementiaAD related dementiaADRDAccelerationAducanumabAdverse effectsAfrican AmericanAfro AmericanAfroamericanAge of OnsetAlzheimer Type DementiaAlzheimer beta-ProteinAlzheimer disease dementiaAlzheimer risk factorAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's Amyloid beta-ProteinAlzheimer's DiseaseAlzheimer's amyloidAlzheimer's and related dementiasAlzheimer's dementia and related dementiaAlzheimer's dementia or related dementiaAlzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementiaAlzheimer's disease related dementiaAlzheimer's disease riskAlzheimer's disease therapeuticAlzheimer's therapeuticAlzheimers DementiaAmyloidAmyloid Alzheimer's Dementia Amyloid ProteinAmyloid Beta-PeptideAmyloid Protein A4Amyloid SubstanceAmyloid beta-ProteinAmyloid βAmyloid β-PeptideAmyloid β-ProteinAβBIIB037Black AmericanBlack PopulationsBlack groupBlack individualBlack peopleBlacksBlossomsBurden on their caregiversCalibrationCare GiversCaregiver BurdenCaregiversCaringCenters for Medicare and Medicaid ServicesClinical Treatment MoabClinical TrialsContinuity of CareContinuity of Patient CareContinuum of CareCost Effectiveness AnalysisCosts and BenefitsDataDecrease health disparitiesDiagnosisDisparitiesDisparityDrug TherapyDrugsEarly treatmentEconometric ModelsEconomicsElementsEquationFamilyFamily memberFinancial HardshipFlowersFocus GroupsFood and Drug AdministrationGrantHealthHealth Care Financing AdministrationHealth Insurance for Aged and Disabled, Title 18Health Insurance for Disabled Title 18Health disparity mitigationHealth disparity reductionHeterogeneityHispanic AmericansIndividuals from minorityIndividuals of minorityInequalityLife ExpectancyLiteratureLogit ModelsLower health disparitiesMeasuresMedicareMedicationMethodologyMethodsMinority GroupsMinority PeopleMinority PopulationMinority individualMitigate health disparitiesModelingMonoclonal AntibodiesMotivationOutcomePatientsPharmaceutical PreparationsPharmacological TreatmentPharmacotherapyPhasePlant BloomsPoliciesPopulationPrevalencePrimary Senile Degenerative DementiaProbabilityQALYQuality-Adjusted Life ExpectancyQuality-Adjusted Life YearsRaceRacesRacial GroupReduce health disparitiesResearchResearch MethodologyResearch MethodsResearch ResourcesResourcesRiskSeverity of illnessStructureSubgroupTherapeuticTitle 18USFDAUnited StatesUnited States Centers for Medicare and Medicaid ServicesUnited States Food and Drug AdministrationUnited States Health Care Financing AdministrationUpdatea beta peptideabetaaduhelmalzheimer riskamyloid betaamyloid-b proteinbeta amyloid fibrilburden in caregiversburden of their caregiversburden on caregiversburden on familiesburden to familiescare giving burdencaregiving burdencaregiving stresscaucasian Americanclinical efficacyclinical trial enrollmentcommunity based participatory researchcommunity engagementcommunity led researchcommunity participatory researchcommunity partnered participatory researchcommunity partnerscommunity-based partnerscostcost effectivenesscost efficient analysiscost estimatecost estimationcost-effective analysisdata modelingdifferences due to racedifferences in racediffers by racediffers in racediscrete datadisease severitydisparities in treatmentdisparity in healthdrug interventiondrug treatmentdrug/agentearly therapyeconomiceconomic valueengagement with communitiesethnic differenceethnic minorityethnicity differenceethnoracialethnoracial minorityexperimentexperimental researchexperimental studyexperimentsfamilial burdenfamily burdenfinancial adversityfinancial burdenfinancial distressfinancial insecurityfinancial strainfinancial stresshealth disparityhealth equityhealth insurance for disabledhealthy aginghealthy human aginginequality in treatmentmAbsmarkov modelmodel of datamodel the datamodel-based simulationmodeling of the datamodels and simulationmonetary valuemonoclonal Absnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyparticipatory action researchpharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspreferenceprimary degenerative dementiarace based differencesrace differencesrace related differencesracialracial backgroundracial differenceracial minorityracial originracial populationracial subgroupracially differentresearch and methodssenile dementia of the Alzheimer typesoluble amyloid precursor proteintreatment and outcometreatment disparitytreatment inequalitytreatment inequitytrendunder served areaunder served geographic areaunder served locationunder served regionunderserved areaunderserved geographic areaunderserved locationunderserved regionuptakewhite American
Description preview
In this project, we will study the implications of the cost effectiveness models new novel treatments for AD/ADRD on health disparities using a combination of Markov models, data from the literature and clinical trials, community based participatory research (CBPR) with focus groups and experimental preference data. First, we will update our…
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