grant
Mayo Clinic Consortium for Gut Brain Communication in Parkinson's Disease
Organization MAYO CLINIC ROCHESTERLocation ROCHESTER, UNITED STATESPosted 1 Sept 2024Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY2025AffectAssayBioassayBiologicalBiological AssayBiopsyBloodBlood Reticuloendothelial SystemBrainBrain Nervous SystemBrain imagingCNS Nervous SystemCentral Nervous SystemChemical ExposureChromatinClinicClinicalCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalColonConstipationCranial Nerve XDNA seqDNA sequencingDNAseqDataData AnalysesData AnalysisData BasesDatabasesDeglutition DisordersDepositDepositionDiseaseDisorderDisturbance in cognitionDorsal Motor Nucleus of the VagusDysfunctionDysphagiaELISAEncephalonEnteralEntericEnteroendocrine CellEnvironmental ExposureEnvironmental ToxinEnzyme-Linked Immunosorbent AssayEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessExposure toFDG PETFe elementFoundationsFunctional disorderFutureGI microbiomeGI microbiotaGastroenterologyGastrointestinal TransitGastrointestinal microbiotaGeneral RadiologyGeneral TaxonomyHigh Performance ComputingImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodImpaired cognitionIndividualInflammationInflammatoryIronLinkMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMetabolicMiceMice MammalsMicrobeMorphologyMotorMucosaMucosal TissueMucous MembraneMurineMusNAC precursorNMR ImagingNMR TomographyNerveNerve CellsNerve DegenerationNerve UnitNeural CellNeuraxisNeurocyteNeurologicNeurologicalNeurologyNeuron DegenerationNeuronsNodose GanglionNuclear Magnetic Resonance ImagingPARK1 proteinPARK4 proteinPETPET ScanPET imagingPETSCANPETTParalysis AgitansParkinsonParkinson DiseasePathway interactionsPatientsPersonsPesticidesPhysiologyPhysiopathologyPneumogastric NervePopulation StudyPositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyPrimary ParkinsonismProcessPrognosisProtein AnalysisQuestionnairesRad.-PETRadiologyRadiology SpecialtyResolutionRiskRisk FactorsSNCASNCA proteinShotgunsStructural defectStructural malformationSwallowing DisordersSymptomsSynapsesSynapticSystems BiologyTaxonomyTenth Cranial NerveTimeToxic Environmental AgentsToxic Environmental SubstancesTransposaseUniversitiesUrgency to pass urineUrgent desire to urinateVagus NerveVagus nerve structureVulnerable PopulationsZeugmatographya-syna-synucleinalpha synucleinalpha synuclein genealphaSP22asynbiologicbiomarker identificationbrain visualizationclinical phenotypeco-morbidco-morbiditycognitive dysfunctioncognitive losscomorbiditycustomized therapycustomized treatmentdata basedata interpretationdigestive tract microbiomedorsal motor nucleusdysbacteriosisdysbiosisdysbioticenteral infectionenteric infectionenteric microbial communityenteric microbiomeenteric microbiotaenteric pathogen infectionenteropathogen infectionenteropathogenic infectionenvironmental toxicantenzyme linked immunoassayepigeneticallyepigenomeexposomefluorodeoxyglucose PETfluorodeoxyglucose positron emission tomographygastrointestinalgastrointestinal functiongastrointestinal microbial floragastrointestinal microbiomegastrointestinal symptomglobal gene expressionglobal transcription profilegut communitygut floragut microbe communitygut microbial communitygut microbial compositiongut microbial consortiagut microbiomegut microbiotagut microbioticgut microfloragut to brain axisgut-associated microbiomegut-brain axisgut-brain communicationgut-brain interactionsgut-brain relationshipgut-brain signalinghigh-end computingidentification of biomarkersidentification of new biomarkersin vivoindividualized medicineindividualized patient treatmentindividualized therapeutic strategyindividualized therapyindividualized treatmentinfected with enteropathogeninnovateinnovationinnovativeintestinal biomeintestinal floraintestinal infectionintestinal microbiomeintestinal microbiotaintestinal microfloraintestinal tract microfloraintestine infectionmarker identificationmetabolomemetabonomemetagenomemicrobialmicrobial imbalancemicturition urgencymotor symptommultidisciplinarymultiomicsmultiple omicsnerve cell deathnerve cell lossneural degenerationneural imagingneuro-imagingneurodegenerationneurodegenerativeneuroimagingneurological degenerationneurological imagingneuron cell deathneuron cell lossneuron deathneuron lossneuronalneuronal cell deathneuronal cell lossneuronal deathneuronal degenerationneuronal lossneuropathologicneuropathologicalneuropathologynon A-beta component of AD amyloidnon A4 component of amyloid precursornon-motor symptomnonmotor symptompanomicspathophysiologypathwaypatient specific therapiespatient specific treatmentperipheral bloodpollutantpopulation-based studypopulation-level studypositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographyresolutionsshot gunsmall moleculestructural abnormalitiesstructural anomaliesstudies of populationsstudy of the populationsynapsetailored medical treatmenttailored therapytailored treatmenttertiary caretranscriptomeunique treatmenturinary urgencyurination urgencyvulnerable groupvulnerable individualvulnerable peopleα synuclein geneα-synα-synuclein
Description preview
PROJECT SUMMARY
Gastrointestinal (GI) symptoms, especially constipation, affect >50% of persons with PD (PwPD). However,
these concepts are exclusively based on tertiary care studies that used incomplete definitions of constipation.
Our population study found that constipation preceded the motor symptoms of PD by up to 20 or more years.
Our…
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