grant
Mast Cell Activation as a Common Mechanism of Pulmonary Toxicity by Chemical Threat Agents
Organization UNIVERSITY OF COLORADO DENVERLocation Aurora, UNITED STATESPosted 1 Sept 2025Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY2025AcuteAcute Lung InjuryAcute Pulmonary InjuryAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryBiological MarkersBody TissuesC57BL/6 MouseCell BodyCell Communication and SignalingCell SignalingCellsChemical Warfare AgentsChemicalsChloraminChlorethazineChlormethineDataDendritic CellsDevelopmentDiesel ExhaustDifferential Gene ExpressionEnvironmentExposure toFormaldehydeFormic AldehydeFutureGene ExpressionGoalsGuidelinesHN-2HN2HealthHeavy MetalsHerbicidesHumanImmuneImmune SurveillanceImmune responseImmunesImmunologic SurveillanceImmunosurveillanceIndustrializationInflammationInflammatoryInflammatory InfiltrateInjuryInnate Immune ResponseInsecticidesIntracellular Communication and SignalingLinkLipidsLocationLungLung InflammationLung Respiratory SystemLung damageMarrow Mast CellMechlorethamineMediatorMethyl AldehydeMethylchlorethamineMiceMice MammalsModelingModern ManMorphologyMucosaMucosal TissueMucous MembraneMurineMusMustineNitrogen MustardO3OutcomeOxomethaneOzonePathway interactionsPesticidesPlayPneumonitisPreventionPublishingPulmonary InflammationPulmonary PathologyResearchRiotsRiskRoleSafetySecuritySignal TransductionSignal Transduction SystemsSignalingSurfaceTerrorismTestingTherapeuticTissue BasophilsTissue-Specific Differential Gene ExpressionTissue-Specific Gene ExpressionTissuesToxic effectToxicitiesVeiled CellsWild Type MouseWorkXenobioticsadaptive immune responsebio-markersbiologic markerbiological signal transductionbiomarkercell typechemical countermeasurechemical threatchemical warfare substanceschip modelchip systemchloromethinecigarette smokedevelopmentalhost responsehuman modelimmune system responseimmunoresponseimprovedin vivoinjurieslipid mediatorlung injurylung pathologymast cellmastocytemodel of humanmouse modelmurine modelnano particlenano-sized particlenanoparticlenanosized particlenew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targeton a chipon chippathwayprogramspulmonarypulmonary damagepulmonary injurypulmonary tissue damagepulmonary tissue injuryrecruitresponsesensorsocial rolespatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicstargeted agentterrorist attacktherapeutic agent developmenttherapeutic biomarkertherapeutic developmenttherapeutic markertherapeutic targettoxicanttranslational modeltreatment effectwildtype mouse
Description preview
Project Abstract
The Department of Homeland Security considers numerous chemical threat agents a concern for human health,
specifically those that are acute pulmonary toxicants. In acute lung injury, inflammation is critical thus we propose
that inflammation is a common mechanism of lung injury caused by chemical threat agents due to mast cell…
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