grant
Mapping the Functional and Anatomical Pathways from the Anterior and Posterior Paraventricular Nucleus of the Thalamus to the Nucleus Accumbens: Implications for Opioid Use
Organization UNIVERSITY OF MINNESOTALocation MINNEAPOLIS, UNITED STATESPosted 1 Sept 2024Deadline 30 Nov 2028
NIHUS FederalResearch GrantFY2026AbateAbstinenceAddressAdoptedAnatomic SitesAnatomic structuresAnatomyAnimalsAnteriorAppetiteBehaviorBrainBrain Nervous SystemBrain regionCalciumCalcium Ion SignalingCalcium SignalingChemical DependenceCommon Rat StrainsComplexComprehensionCue-induced relapseCuesDataDesire for foodDiacetylmorphineDiamorphineDifferences between sexesDiffers between sexesDihydrohydroxycodeinoneDissectionDrug AddictionDrug DependenceDrug DependencyDrug usageDrugsElectrophysiologyElectrophysiology (science)EncephalonEndocrine Gland SecretionEstrous CycleFemaleFiberFoundationsFutureGlutamatesGoalsGrantHeroinHormonesHumanImageImpairmentIndividualIntravenousInvestigatorsKnowledgeL-GlutamateLinkLongitudinal StudiesLongitudinal SurveysMapsMeasuresMedicalMedicationMethodologyModern ManModernizationMonitorNerve CellsNerve Transmitter SubstancesNerve UnitNeural CellNeurocyteNeuronsNeurophysiology / ElectrophysiologyNeurosciencesNeurotransmittersNucleus AccumbensOpiatesOpioidOpticsOutcomeOvarian hormoneOxycodeinonOxycodoneOxycodone SROxycontinParaventricular Nucleus of ThalamusParaventricular Thalamic NucleusPathway interactionsPatternPharmaceutical AgentPharmaceutical PreparationsPharmaceuticalsPharmacologic SubstancePharmacological SubstancePhasePhotometryPhysiologicPhysiologicalPhysiologyPostdocPostdoctoral FellowPreventionR-Series Research ProjectsR01 MechanismR01 ProgramRatRat TransgeneRats MammalsRattusRecoveryRelapseResearchResearch AssociateResearch GrantsResearch PersonnelResearch Project GrantsResearch ProjectsResearchersRewardsRiskRodentRodentiaRodents MammalsRoleRoxicodoneSelf AdministeredSelf AdministrationSeveritiesSex DifferencesSexual differencesSociologySolidStructure of paraventricular nucleus of thalamusSymptomsSynapsesSynapticSynaptic plasticitySystemTechniquesTestingThalamic structureThalamusTransmissionWithdrawal SymptomWorkabused drugabused drugsaddictionaddictive disorderaffective neurosciencecell typecomparing females and malescomparing women and mencompulsioncravingdaily functioningdebilitating symptomdesigndesigningdrug abuseddrug of abusedrug usedrug/agentdrugs abuseddrugs of abuseelectrophysiologicalexperienceexperimentexperimental researchexperimental studyexperimentsfemales compared to malesfemales compared with malesfemales versus malesfemales vs. malesglutamatergicimagingimprovedin vivoinnervationinnovateinnovationinnovativeintravenous opiateintravenous opioidlong-term recoverylong-term studylongitudinal outcome studieslongitudinal research studymalenegative affectnegative affectivitynerve supplyneural circuitneural circuitryneural mechanismneurocircuitryneuromechanismneuronalopiate consumptionopiate drug useopiate injectionopiate intakeopiate useopiate use disorderopiate withdrawalopioid consumptionopioid detoxopioid detoxificationopioid drug useopioid injectionopioid injectoropioid intakeopioid useopioid use disorderopioid withdrawalopticaloptogeneticsoxycodone self-administrationpathwaypharmaceuticalpost-docpost-doctoralpost-doctoral traineeprogramsprolonged abstinencepsychologicpsychologicalrelapse riskresearch associatesresponseself-administer oxycodonesensorsexsex based differencessex-dependent differencessex-related differencessex-specific differencessocial rolesustained abstinencesynapsesynapse functionsynaptic circuitsynaptic circuitrysynaptic functionthalamictooltransmission processwomen compared to menwomen compared with menwomen versus menwomen vs. men♀♂
Description preview
PROJECT ABSTRACT
Opioid Use Disorder (OUD) is a complex medical condition characterized by compulsive and maladaptive use
of opioid substances, including prescribed pharmaceuticals (such as oxycodone) and illegal agents (such as
heroin). It causes physiological, psychological, and sociological effects, including tolerance, withdrawal
symptoms,…
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