grant
Mapping temporomandibular joint (TMJ) degeneration and pain
Organization UNIVERSITY OF SOUTHERN CALIFORNIALocation Los Angeles, UNITED STATESPosted 1 Jul 2024Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY20263-D3-D Imaging3-Dimensional3D3D imagingATAC sequencingATAC-seqATACseqAdoptedAffectAfferent NeuronsArthralgiaAssayAssay for Transposase-Accessible Chromatin using sequencingAtlasesAutomobile DrivingAxonBehaviorBioassayBiological AssayBiologyCell BodyCell CommunicationCell InteractionCell NucleusCell-to-Cell InteractionCellsChondrocytesChromatinChronicClinicalCo-cultureCocultivationCocultureCoculture TechniquesDataDegenerative ArthritisDegenerative polyarthritisDependenceDevelopmentDiseaseDisorderEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessFibroblastsFoundationsFreund's AdjuvantFreund's Complete AdjuvantGWA studyGWASGasser's GanglionGasserian GanglionGene ExpressionGeneralized GrowthGenerationsGeneticGoalsGrowthHumanHyperactivityHyperalgesiaHyperalgesic SensationsImageImaging technologyIn VitroIndividualInflammationInflammatoryInvestigatorsJaw JointJoint PainJointsLigandsMandibular jointMapsMediatingMediatorMethodologyMiceMice MammalsModelingModern ManMolecularMouse Homolog of NETRIN 1MurineMusNETRIN 1-LikeNTN1NTN1 geneNTN1 gene productNTN1LNerveNerve CellsNerve UnitNeural CellNeurocyteNeuronsNeurosciencesNociceptionNucleusOpiatesOpioidOrofacial PainOsteoarthritisOsteoarthrosisOsteoclastsOsteocytesPainPainfulPathologyPatientsPopulationPositionPositioning AttributePublishingReceptor ProteinResearch PersonnelResearchersResolutionRisk-associated variantSemilunar GanglionSensorySensory NeuronsSingle-Nucleus SequencingSolventsStructure of trigeminal ganglionSynoviaSynovial FluidSystemTMJTMJ osteoarthritisTMJ-OATemporomandibular JointTemporomandibular OsteoarthritisTemporomandibular joint (TMJ) osteoarthritisTemporomandibular joint osteoarthritisTestingThree-Dimensional ImagingTissue GrowthTrigeminal GangliasTrigeminal GanglionWorkafferent nerveassay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingaxon growthaxon growth cone guidanceaxon guidanceaxonal growthcell typechronic painconnectomecraniofacialcraniofaciesdegenerative joint diseasedevelopmentaldrivingeffective therapyeffective treatmentepigeneticallyepigenomicsgenome wide associationgenome wide association scangenome wide association studygenomewide association scangenomewide association studyglobal gene expressionglobal transcription profilehigh dimensionalityhyperalgiahypertrophic arthritisimage-based methodimagingimaging methodimaging modalityin vivoinnervationinsightjoint degenerationjoint degradationjoint destructionjoint tissue degenerationmechanical loadmouse geneticsmouse modelmulti-modalitymultimodalitymultiomicsmultiple omicsmurine modelnerve supplynetrin-1neuralneural circuitneural circuitryneurocircuitryneuronalneuronal growthnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnociceptivenovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetontogenyopiate exposureopioid exposureoral facial painosteoarthritis associated painosteoarthritis painpain behaviorpanomicsreceptorresolutionsrisk allelerisk generisk genotyperisk locirisk locusrisk variantsNuc-SeqscRNA sequencingscRNA-seqsensory nervesingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle nucleus RNA-sequencingsingle nucleus seqsingle-cell RNA sequencingsingle-nucleus RNA-seqskillssnRNA sequencingsnRNA-seqsynaptic circuitsynaptic circuitrytherapeutic targetthree dimensionaltranscriptometranscriptomicswhole genome association analysiswhole genome association study
Description preview
PROJECT SUMMARY/ABSTRACT
Temporomandibular joint (TMJ) osteoarthritis (TMJOA) is a degenerative disease of the joint. It has been
challenging to manage and treat TMJOA due to our limited understanding of the molecular, cellular, and neuronal
mechanisms underlying TMJOA. The goal of this proposal is to use multi-modal single-cell and imaging…
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