grant
Mapping systems of DNA repair with high-resolution functional genomics
Organization PRINCETON UNIVERSITYLocation Princeton, UNITED STATESPosted 25 Aug 2020Deadline 28 Feb 2031
NIHUS FederalResearch GrantFY2026CancersCell BodyCell Communication and SignalingCell SignalingCellsDNADNA DamageDNA Damage RepairDNA InjuryDNA RepairDNA Repair GeneDNA SequenceDNA lesionDNA mutationDNA repair proteinDefectDeoxyribonucleic AcidDetectionDiseaseDisorderFutureGeneticGenetic ChangeGenetic defectGenetic mutationGenomeGenome StabilityGenomic StabilityGenomic approachGenomicsHealthHumanIndividualIntracellular Communication and SignalingMalignant NeoplasmsMalignant TumorMapsMismatch RepairModelingModern ManMutationNervous System DiseasesNervous System DisorderNeurologic DisordersNeurological DisordersPathway interactionsPost-Replication Mismatch RepairPredispositionProcessResearchResolutionReverse TranscriptionRoleSignal TransductionSignal Transduction SystemsSignalingSusceptibilitySystemTechnologyUnscheduled DNA SynthesisWritingbiological signal transductionexperimentexperimental researchexperimental studyexperimentsfunctional genomicsgene functiongene locusgene repairgenetic locusgenome editinggenome mutationgenomic editinggenomic effortgenomic locationgenomic locusgenomic strategyhigh definitionhigh-resolutionhuman diseaseinnovateinnovationinnovativeinsightmalignancymutation scanningmutation screeningneoplasm/cancerneurological diseasenovelpathwayprime editingrepairrepairedresolutionsresponsesocial roletech developmenttechnology developmenttool
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PROJECT SUMMARY
Defining the mechanisms that detect, signal, and repair distinct forms of DNA damage in human cells has been
a major research focus for decades. At this point, we know a lot about how different DNA lesions are recognized,
how repair processes are regulated, and how defects in those processes alter susceptibility to human diseases,…
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