grant
Mapping p53 dynamics to cell-fate outcomes in reprogramming and oncogenesis
NIHUS FederalResearch GrantFY20253-D modeling3D modelingAddressAdoptedAntioncogene Protein p53Artificial GenesAttentionBackBasal Transcription FactorBasal transcription factor genesBehaviorBindingBody TissuesBreast TissueBypassCancer GenesCancer InductionCancer ModelCancer-Promoting GeneCancerModelCancerousCancersCell BodyCell DifferentiationCell Differentiation processCell FractionCell IsolationCell ReprogrammingCell SegregationCell SeparationCell Separation TechnologyCellsCellular Tumor Antigen P53DNA Binding DomainDNA mutationDNA-Binding Protein MotifsDiagnosisDiseaseDisorderDorsumEarly DiagnosisEctodermEndodermEngineeringEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEpithelial CellsEpitheliumEventFallopian TubesFibroblastsFrequenciesGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenerationsGenesGenetic ChangeGenetic TranscriptionGenetic defectGenetic mutationGenomicsHuman DevelopmentImmuneImmunesInvestigationLeadLinkMalignant NeoplasmsMalignant Ovarian NeoplasmMalignant Ovarian TumorMalignant TumorMalignant Tumor of the OvaryMalignant neoplasm of ovaryMammalian OviductsMammary Gland ParenchymaMammary Gland TissueMapsMediatingMesodermMetastasisMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic TumorMiceMice MammalsModelingMolecularMolecular InteractionMotor CellMotor NeuronsMurineMusMutateMutationNeoplasm MetastasisNerve CellsNerve UnitNeural CellNeurocyteNeuronsOncogenesOncogenesisOncogenicOncoprotein p53OrganismOrganoidsOutcomeOvary CancerP53Patient outcomePatient-Centered OutcomesPatient-Focused OutcomesPb elementPhasePhenotypePhosphoprotein P53Phosphoprotein pp53Point MutationPostdocPostdoctoral FellowProcessProgenitor CellsProliferatingProtein TP53ProteinsRNA ExpressionRegulationReporterReportingResearchResearch AssociateRoleSalpinxSamplingSecondary NeoplasmSecondary TumorSkinSomatic CellStaining methodStainsSynthetic GenesSystemTP53TP53 geneTRP53TherapeuticTissuesTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTransforming GenesTumor Protein p53Tumor Protein p53 GeneTumor Suppressor ProteinsUterine TubesWorkcancer initiationcancer metastasiscancer progressioncarcinogenesiscell sortingcell typecellular differentiationcellular reprogrammingdesigndesigningdifferentiation of pluripotent stem cellsearly detectioneffective therapyeffective treatmentenhancing factorepigeneticallygain of functiongenome mutationheavy metal Pbheavy metal leadhiPSChuman iPShuman iPSChuman induced pluripotent cellhuman induced pluripotent stem cellshuman inducible pluripotent stem cellshuman inducible stem cellsiPSiPSCiPSCsimprovedinduced human pluripotent stem cellsinduced pluripotent cellinduced pluripotent stem cellinducible pluripotent cellinducible pluripotent stem cellliving systemmalignancymotoneuronmutantneoplasm progressionneoplasm/cancerneoplastic progressionneuronalovarian canceroverexpressoverexpressionoviductp53 Antigenp53 Genesp53 Tumor Suppressorpatient oriented outcomespluripotent stem cell differentiationpost-docpost-doctoralpost-doctoral traineepreventpreventingprogenitor cell fateprogenitor cell fate specificationprogenitor fateprogenitor fate specificationprogenitor specificationprogramsprotein p53research associatessensorshRNAshort hairpin RNAsmall hairpin RNAsocial rolestem and progenitor cell fatestem cell fatestem cell fate specificationstem cell specificationstem cellssuccesstargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmentthree-dimensional modelingtranscription factortrendtumortumor cell metastasistumor initiationtumor progressiontumor suppressortumorigenesis
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Project Summary
Cell fates are decided as an organism develops. In human development, pluripotent stem cells
differentiate into the three layers of ectoderm, mesoderm, and endoderm. These classes of tissue further
differentiate into specific cell types with specific functions including neurons, immune cells, and skin cells. These
identities are…
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