grant
Mapping of Electron Tunneling Pathways in Proteins
NIHUS FederalResearch GrantFY20253-D3-Dimensional3DApoptosisApoptosis PathwayAreaBacteriaBelgiumBiologicalBiological FunctionBiological ProcessBiologyBiophysicsBiotechBiotechnologyBuffersCaliforniaCell BodyCellsCharacteristicsChargeChemicalsChemistryCollaborationsCorrelation StudiesDNA Damage RepairDNA RepairDNA ReplicationDNA SynthesisDNA biosynthesisDataDenmarkDevelopmentDimensionsDiseaseDisorderElectric ConductivityElectrical ConductivityElectronicsElectronsEnvironmentFerroprotoporphyrinFree EnergyFutureHemeHeme ProteinsHemeproteinsInfectionIslandKineticsLengthLettersLinkMapsMeasurementMediatingMethodsModelingMolecularNatureNegative Beta ParticleNegatronsOrganismOxidation-ReductionOxidative StressPathway interactionsPeriodicalsPlayPower SourcesPower SuppliesProcessProgrammed Cell DeathProliferatingPropertyProteinsProtohemeQuantum MechanicsReactionRedoxReportingResearchRespirationStatistical CorrelationStatistical MechanicsStructural ModelsStructureStructure-Activity RelationshipSystemTestingTherapeuticUniversitiesUnscheduled DNA Synthesisbasebasesbiologicbiophysical foundationbiophysical principlesbiophysical scienceschemical structure functioncofactorcombatcomputer based predictiondevelopmentalelectrical conductanceelectronicelectronic deviceexperimentexperimental groupexperimental researchexperimental studyexperimentsextracellularferrohemehemoproteinhigh dimensionalityinterestliving systemmeternano meter scalenano meter sizednanometernanometer scalenanometer sizednanoscalenanowirenext generationnoveloxidation reduction reactionparticlepathwayperiodicperiodicalpredictive modelingprotein structureprotein structuresproteins structurerecruitrespiratory mechanismresponsesimulationstructure function relationshiptheoriesthree dimensionaltool
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Project Summary
Protein-mediated charge-transfer (CT) lies at the heart of energy processing in living systems [1, 2]. The
chemistry of biocatalysis, oxidative stress, DNA synthesis and repair, and apoptosis all engage CT pathways
[3, 4], and the malfunction of CT networks leads to disease. Understanding how CT pathways function - at the…
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