grant

Mapping cerebellar influence in FTD: unraveling the role of the cerebellum in social cognition and clinical trajectory

Organization UNIVERSITY OF CALIFORNIA, SAN FRANCISCOLocation SAN FRANCISCO, UNITED STATESPosted 1 Mar 2026Deadline 29 Feb 2028
NIHUS FederalResearch GrantFY2026AccountingAddressAgingAmentiaArchitectureAtrophicAtrophyAwardBiological MarkersBrainBrain Nervous SystemBurden on their caregiversCaliforniaCaregiver BurdenCerebellar degenerationCerebellumCerebrumClinicalClinical DataCognitionCognitiveCognitive DisturbanceCognitive ImpairmentCognitive ManifestationsCognitive SymptomsCognitive declineCognitive deficitsCognitive function abnormalComplexDataData SetDegenerative Neurologic DisordersDementiaDiagnosisDiagnosticDiseaseDisease ProgressionDisease stratificationDisorderDistressDisturbance in cognitionEarly DiagnosisEarly identificationEmotionsEmpathyEncephalonEngineering / ArchitectureEnvironmentFTLDFoundationsFrontal Temporal Lobar DegenerationFrontotemporal Lobar DegenerationsFrontotemporal variety lobar degenerationFunctional impairmentFutureGoalsImageImpaired cognitionImpairmentIndividualInferiorInstitutionInterventionIntervention StrategiesInvestigationInvestigatorsLeadLifeLinkMapsMeasuresMemoryMentorshipModelingMonitorMotorNational Institutes of HealthNerve CellsNerve DegenerationNerve UnitNervous System Degenerative DiseasesNeural CellNeural Degenerative DiseasesNeural degenerative DisordersNeurocyteNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNeuron DegenerationNeuronsNeuropsychologiesNeuropsychologyOutcomePatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPb elementPhasePositionPositioning AttributePredictive ValueProcessReadingResearchResearch PersonnelResearch ResourcesResearchersResourcesRoleSan FranciscoSemanticsSeriesSeveritiesSiteSocial BehaviorStructureSymptomsTechniquesTestingTherapeuticTrainingUnited States National Institutes of HealthUniversitiesanalyzing longitudinalbehavioral variant FTDbehavioral variant frontotemporal degenerationbehavioral variant frontotemporal dementiabio-markersbiologic markerbiomarkerbrain atrophybrain behaviorburden in caregiversburden of their caregiversburden on caregiversbvFTDcareercareer developmentcerebellum degenerationcerebralcerebral atrophyclinical predictorscognitive defectscognitive dysfunctioncognitive losscognitive neurosciencecohortcomputer based predictioncortical atrophydata resourcedecline in functiondecline in functional statusdegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesearly detectionfunctional adaptationfunctional declinefunctional status declineheavy metal Pbheavy metal leadimagingimprovedinsightlongitudinal analysismulti-modal neuro-imagingmulti-modalitymultimodal neuroimagingmultimodalitynetwork dysfunctionneuralneural degenerationneural imagingneural mechanismneuro-imagingneurodegenerationneurodegenerativeneurodegenerative illnessneuroimagingneuroimaging biomarkerneuroimaging markerneurological degenerationneurological imagingneuromechanismneuronalneuronal degenerationneuropsychiatricneuropsychiatric symptomneuropsychiatryneuropsychologicnovelpatient oriented outcomespredictive biological markerpredictive biomarkerspredictive markerpredictive modelingpredictive molecular biomarkerprognosis modelprognostic modelprogramspsychiatric symptomsocialsocial cognitionsocial influencesocial rolesociobehaviorsociobehavioraltheory of mind
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PROJECT SUMMARY/ABSTRACT
Behavioral variant frontotemporal dementia (bvFTD) is a devastating neurodegenerative disorder characterized

by early and profound social cognitive deficits, including impairments in theory of mind, emotion reading, and

empathy, which cause significant distress and burden for caregivers. While research has traditionally…

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Mapping cerebellar influence in FTD: unraveling the role of the cerebellum in social cognition and clinical trajectory — | Dev Procure