grant
Mapping biophysical effects of the cellular environment on p53 and PTEN stability and aggregation
Organization SAN JOSE STATE UNIVERSITYLocation SAN JOSE, UNITED STATESPosted 1 Sept 2025Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY2025AddressAffectAffinityAmyloidAmyloid FibrilsAmyloid ProteinsAmyloid SubstanceAntioncogene Protein p53AssayAutomobile DrivingBackBasal Transcription FactorBasal transcription factor genesBioassayBiochemicalBiological AssayBiologyBiophysicsCancer CauseCancer EtiologyCancersCellular ExpansionCellular GrowthCellular TransformationCellular Tumor Antigen P53ChemicalsCircular DichroismCollectionColoring AgentsDNA BindingDNA Binding InteractionDNA boundDNA mutationDevelopmentDimensionsDiseaseDisorderDorsumDyesDysfunctionEnvironmentEnvironmental FactorEnvironmental Risk FactorEnzyme GeneEnzyme KineticsEnzymesEsteroproteasesEventExhibitsFluorescenceFoundationsFunctional disorderGeneral Transcription Factor GeneGeneral Transcription FactorsGeneralized GrowthGenetic ChangeGenetic PolymorphismGenetic defectGenetic mutationGenotypeGoalsGrowthHeterogeneityHumanIndividualKnowledgeLibrariesLinkLipidsMMAC1MMAC1 proteinMT-bound tauMalignant CellMalignant NeoplasmsMalignant TumorMapsMeasuresMetabolicMetabolite InteractionModern ManModificationMolecularMolecular ConfigurationMolecular ConformationMolecular ProbesMolecular StereochemistryMutated in Multiple Advanced Cancers 1MutationOncogenesisOncogenicOncoprotein p53OutcomeP53PHTS genePHTS proteinPTENPTEN genePTEN proteinPTEN1PathologicPeptidasesPeptide HydrolasesPhenotypePhosphatase and Tensin HomologPhosphatase and Tensin Homolog Deleted on Chromosome 10PhosphatasesPhosphohydrolasesPhosphomonoesterasesPhosphoprotein P53Phosphoprotein PhosphatasePhosphoprotein Phosphatase-2CPhosphoprotein PhosphohydrolasePhosphoprotein pp53Phosphoric Monoester HydrolasesPhosphorylationPhosphorylation SitePhysiopathologyPlayPositionPositioning AttributePost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingPredispositionProcessProtease GeneProteasesProtein ConformationProtein ModificationProtein Phosphatase CProtein Phosphatase GeneProtein Phosphatase-1Protein Phosphatase-2AProtein PhosphorylationProtein TP53Protein phosphataseProteinasesProteinsProteolytic EnzymesProteomeProteomicsRecombinantsReportingResearchResistanceRoleRouteSamplingScanningScientistSignaling Factor Proto-OncogeneSignaling Pathway GeneSignaling ProteinSiteStructureStudentsSusceptibilitySystemTP53TP53 geneTRP53TemperatureTestingTherapeuticThermodynamicThermodynamicsTissue GrowthTranscription Factor Proto-OncogeneTranscription factor genesTumor Protein p53Tumor Protein p53 GeneTumor Suppressor ProteinsUbiquitilationUbiquitinationUbiquitinoylationUniversitiesWorkaberrant protein foldingabnormal protein foldingabnormally aggregated tau proteinaggregation pathwayamyloid assemblyamyloid formationbiological adaptation to stressbiophysical foundationbiophysical principlesbiophysical sciencescancer cellcell growthcofactorcomputer based predictionconformationconformationalconformational stateconformationallyconformationsdevelopmentaldrivingempowermentenvironmental riskexperimentexperimental researchexperimental studyexperimentsfilamentous tau inclusionfrontiergenome mutationin vitro Modelin vivoinnovateinnovationinnovativeinsightinsoluble aggregateloss of functionmalignancymeltingmetaplastic cell transformationmicrotubule associated protein tau aggregationmicrotubule associated protein tau depositmicrotubule bound taumicrotubule-bound taumodel buildingmolecular recognitionmutated in multiple advanced cancers 1 proteinneoplasm/cancerontogenyp53 Antigenp53 Genesp53 Tumor Suppressorpaired helical filament of taupathologic protein foldingpathophysiologypersonalization of treatmentpersonalized medicinepersonalized therapypersonalized treatmentphosphatase and tensin homologue on chromosome tenpolyanionpolymorphismpredictive modelingprotective effectprotein aggregateprotein aggregationprotein foldingprotein functionprotein metaboliteprotein misfoldingprotein p53reaction; crisisreconstitutereconstitutionresistantscale upself-aggregate tausmall moleculesocial rolestress responsestress; reactiontautau PHFtau Proteinstau accumulationtau aggregatetau aggregationtau factortau fibrillizationtau filamenttau neurofibrillary tangletau oligomertau paired helical filamenttau polymerizationtau-tau interactiontooltranscription factortumor suppressortumorigenesisubiquinationubiquitin conjugationundergradundergraduateundergraduate studentτ Proteinsτ aggregation
Description preview
PROJECT SUMMARY/ABSTRACT
Cancers are marked by misregulation of tumor suppressor proteins and changes to the cellular environment
caused by grossly altered metabolic states. It is possible that the altered chemical environment of cancer cells
induces destabilization of a protein’s folded state or protein misfolding and aggregation. Indeed, the…
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