grant
Mapping 3D-genome motion with next generation tracking technology to distinguish molecular drivers of cis-regulatory control
Organization STANFORD UNIVERSITYLocation STANFORD, UNITED STATESPosted 8 Sept 2025Deadline 31 Jul 2029
NIHUS FederalResearch GrantFY20253-D3-D structure3-Dimensional3-dimensional structure3D3D structureAccelerationAddressAdhesivesAffectArchitectureBehaviorBiologyBiophysicsBypassCell BodyCell Communication and SignalingCell LineCell SignalingCellLineCellsChromatinChromatin StructureCommunicationComplexCoupledDNADancingDataDeoxyribonucleic AcidDevelopmentDiseaseDisorderElementsEngineering / ArchitectureEnhancersEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEstrogensEventExhibitsFrequenciesGene ExpressionGene TranscriptionGeneralized GrowthGenerationsGenesGeneticGenetic TranscriptionGenomeGenomic SegmentGenomicsGrowthHealthHi-CImageImaging technologyIntracellular Communication and SignalingKineticsLabelLibrariesMCF-7MCF-7 CellMCF-7DRMCF-7WTMCF7MCF7 cellMapsMeasuresMediatingMethodsMicroscopyModelingMolecularMotionMotorNon-Polyadenylated RNAOpticsPathway interactionsPhasePolymersPopulationProcessProteinsPublicationsRNARNA ExpressionRNA Gene ProductsRegulatory ElementReporterResolutionRibonucleic AcidScientific PublicationShapesSignal TransductionSignal Transduction SystemsSignalingSiteSpeedStrains Cell LinesTechniquesTechnologyTestingTheoretic ModelsTheoretical modelTherapeutic EstrogenTimeTissue GrowthTitrationsTopoisomeraseTranscriptionTranscriptional ControlTranscriptional RegulationVariantVariationbiological signal transductionbiophysical foundationbiophysical modelbiophysical principlesbiophysical sciencescell behaviorcell fixationcell fixingcellular behaviorcohesincultured cell linedensitydevelopmentalepigeneticallyflexibilityflexiblegenome segmentgenomic regionimage-based methodimagingimaging approachimaging based approachimaging methodimaging modalityimprovedinnovateinnovationinnovativeinsightminiaturizeminiaturizednext generationontogenyopticalpathwaypharmacologicpolymerpolymericpromoterpromotorreconstructionresolutionsresponsesimulationspatial and temporalspatial temporalspatiotemporaltemporal measurementtemporal resolutiontheoriesthree dimensionalthree dimensional structuretime measurement
Description preview
Transcriptional regulation and resulting development and health/disease states are shaped by the underlying 3D
organization of the genome. Recent advances in single-cell genome-organization techniques (including Optical
Reconstruction of Chromatin Architecture (ORCA) developed in the Boettiger lab), in parallel to recent theoretical
models, have…
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