grant
Manipulating Sex Hormone Signaling for Therapeutic Benefit in Liver Cancer
NIHUS FederalResearch GrantFY20255 alpha-Dihydrotestosterone5-alpha-DHTAgonistAndrogen ReceptorAndrostanoloneAnti-VEGFAnti-VEGF Humanized Monoclonal AntibodyAnti-VEGF RhuMAbAntioncogene Protein p53AttentionAwardBasal Transcription FactorBasal transcription factor genesBiologyBreast CancerCancer CauseCancer EtiologyCarcinoma CellCastrationCell BodyCell LineCellLineCellsCellular Tumor Antigen P53Cessation of lifeCharacteristicsClinical OncologyClinical TrialsColorectal CancerDNA mutationDataDeathDevelopmentDifferences between sexesDiffers between sexesDihydrotestosteroneDiseaseDisorderDissociationElementsEnvironmentExpression SignatureFK506 Binding Protein 12-Rapamycin Associated Protein 1FKBP12 Rapamycin Complex Associated Protein 1FRAP1FRAP1 geneFRAP2FellowshipFemaleFoundationsFutureGEM modelGEMM modelGene Expression ProfileGeneral Transcription Factor GeneGeneral Transcription FactorsGeneralized GrowthGenetic ChangeGenetic defectGenetic mutationGenetically Engineered MouseGlycolysisGoalsGonadal Steroid HormonesGrowthHamartinHepatic CancerHepatic CellsHepatic NeoplasmsHepatic Parenchymal CellHepatocarcinomaHepatocarcinoma modelHepatocellular CarcinomaHepatocellular cancerHepatocyteHepatomaHeterograftHeterologous TransplantationHormonalHumanImmuneImmunesIncrease lifespanInvadedKnowledgeLaboratoriesLiverLiver CellsLiver Cells CarcinomaLiver neoplasmsMalignant Breast NeoplasmMalignant Epithelial CellMalignant neoplasm of liverMalignant neoplasm of prostateMalignant prostatic tumorMeasuresMechanistic Target of RapamycinMediatingMediatorMetabolicMethodsMiceMice MammalsMitochondriaMoAb VEGFModelingModern ManMolecularMonoclonal Antibody Anti-VEGFMurineMusMutationOncogenicOncoprotein p53OrganoidsOutcomeOutputP53PatientsPhosphoprotein P53Phosphoprotein pp53PhysiciansPopulationPreventionPrimary carcinoma of the liver cellsProblem SolvingProductivityProliferatingPropertyProstate CAProstate CA therapyProstate CancerProstate Cancer therapyProstate malignancyProtein TP53RAFT1RNA SeqRNA sequencingRNAseqRapamuneRapamycinReceptor ActivationReceptor InhibitionReceptor SignalingRecombinant Humanized Anti-VEGF Monoclonal AntibodyRecombinant Humanized Monoclonal Antibody to Vascular Endothelial Growth FactorResearchRespirationRhuMAb VEGFRoleScientistSex DifferencesSex HormonesSex Steroid HormonesSexual differencesSignal PathwaySirolimusStanoloneStrains Cell LinesSurgical CastrationTP53TP53 geneTRP53TSC1TSC1 geneTestingTherapeuticTherapeutic AndrostanoloneTissue GrowthTrainingTranscription Factor Proto-OncogeneTranscription factor genesTumor BurdenTumor CellTumor LoadTumor Protein p53Tumor Protein p53 GeneUnited StatesWomanXenograftXenograft procedureXenotransplantationadipogenesisbevacizumabboost longevitycancer microenvironmentcareer developmentclinical trainingcohortcombinatorialcultured cell linedevelopmentaleffective therapyeffective treatmentelongating the lifespanenhance longevityexperimentexperimental researchexperimental studyexperimentsextend life spanextend lifespanextend longevityfoster longevitygene expression patterngene expression signaturegenetically engineered mouse modelgenetically engineered murine modelgenome mutationglobal gene expressionglobal transcription profilegonadal steroidshepatic body systemhepatic neoplasiahepatic neoplasmhepatic organ systemhepatic tumorhepatocellular carcinoma cancer modelhepatocellular carcinoma modelhormonal signalshormone signalsimprove lifespanimprove longevityin vivointervention armlifespan extensionlipid biosynthesislipogenesisliver cancerliver cancer modelliver carcinomaliver developmentliver malignancyliver tumormTORmTOR inhibitionmalemalignant breast tumormalignant liver tumormammalian target of rapamycinmenmigrationmitochondrialmouse modelmultidisciplinarymurine modelneoplastic cellnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeutic targetnew therapy approachesnew therapy targetnew treatment approachnew treatment strategynovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeutic targetnovel therapy approachnovel therapy targetontogenyp53 Antigenp53 Genesp53 Tumor Suppressorpreventpreventingprogramsprolong lifespanprolong longevitypromote lifespanpromote longevityprostate cancer treatmentprotein p53respiratory mechanismrhuMabVEGFscRNA sequencingscRNA-seqsex based differencessex steroidsex-dependent differencessex-related differencessex-specific differencessingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingskillssocial rolestandard of caresupport longevitytherapeutically effectivetraittranscription factortranscriptional profiletranscriptional signaturetranscriptometranscriptome sequencingtranscriptomic sequencingtreatment armtreatment strategytuberous sclerosis 1tumortumor growthtumor microenvironmentxeno-transplantxeno-transplantation♀♂
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Project Summary/Abstract
Hepatocellular carcinoma (HCC) is on track to surpass breast, prostate, and colorectal cancer to become the
third-leading cause of cancer death in the United States by 2040. HCC-related deaths in men outnumber those
in women by more than 3:1 and this is thought to be due to male hormone signaling mediated by the…
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