grant

Mammary Epithelium Permeability, Lactation Outcomes, and Infant Health

Organization UNIVERSITY OF MASSACHUSETTS AMHERSTLocation HADLEY, UNITED STATESPosted 11 Aug 2023Deadline 31 May 2028
NIHUS FederalResearch GrantFY202537 weeks completed gestation37 weeks gestation3rd trimesterAb-mediated immunityAb-mediated protectionAcademyAddressAffectAllergic DiseaseAmericanAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryAntibodiesAntibody immunityAntibody protectionAntibody-mediated protectionAutoimmune DiseasesBacteriaBehavioralBilateralBirthBlackBlack raceBody TissuesBreastBreast FeedingBreast MilkBreast fedBreastfedBreastfeedingBreastmilkCarbohydratesCohort StudiesConcurrent StudiesCounselingDataDietary InterventionDrugsElementsEnrollmentFatsFatty acid glycerol estersGI microbiomeGeneralized GrowthGeographyGoalsGrowthGrowth AgentsGrowth FactorGrowth SubstancesGrowth and DevelopmentGrowth and Development functionGut EpitheliumHealthHealth BenefitHispanicHumanHuman MilkHuman Mother's MilkImmuneImmune systemImmunesIndigenousInfantInfant HealthInflammationInflammatoryInterventionIntestinalIntestinesKnowledgeLactationLast TrimesterLifeLinkLiteratureLongitudinal StudiesMaintenanceMammary Gland MilkMassachusettsMeasuresMedicationMilkModern ManMother's MilkMothersNa elementNew MexicoNutrientNutrition InterventionsNutritionalNutritional InterventionsOutcomeParentsParticipantParturitionPathway interactionsPatternPediatricsPerceptionPeriodicalsPermeabilityPharmaceutical PreparationsPhysiologicPhysiologicalPhysiologyPopulationPostpartum PeriodPregnant WomenPrevalenceProbioticsProteinsProteins Growth FactorsPublic HospitalsQuestionnairesRecommendationReportingResearchRisk FactorsRoleSeveritiesSodiumSupplementationSystems DevelopmentTestingThird Pregnancy TrimesterThird TrimesterTissue GrowthTissuesUnited StatesWeaningWomanWorkantibody-mediated immunityautoimmune conditionautoimmune disorderautoimmunity diseasebowelbreast epitheliumchild adipositychild obesitychildhood adipositychildhood obesityclinical practiceclinical relevanceclinically relevantcohortcytokinediet interventiondietarydigestive tract microbiomedrug/agentdysbacteriosisdysbiosisdysbioticenrollenteric microbiomeethnic diversityethnically diverseexpectant motherexpectant womenexpecting motherexpecting womenfecal samplegastrointestinal epitheliumgastrointestinal microbiomegut microbiomegut-associated microbiomeimprovedimproved outcomeindividuals who are pregnantinfection riskintestinal biomeintestinal microbiomelactatinglactationallong-term studylongitudinal outcome studiesmammarymammary epitheliummastitismaternal milkmicrobialmicrobial imbalancemicrobiomemicrobiome community compositionmicrobiome compositionmicrobiome species compositionmicrobiome structuremilk microbiomemilk removalmilk secretionmilk supplynovelnutritiousobese childrenobesity during childhoodobesity in childrenontogenyparentpathwaypediatric obesitypeople who are pregnantperiodicperiodicalpost-partumpregnant femalespregnant motherspregnant peoplepregnant populationspreventpreventingracial diversityracially diverserecruitsecrete milksocial rolestool samplestool specimenthose who are pregnantwomen who are pregnant
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Project Summary/Abstract
Human milk provides significant health benefits for infants. Beyond nutrients, breastmilk contains antibodies for

immunity, growth factors associated with gut epithelial maturation, bacteria for establishment of the gut

microbiome, and metabolites that modulate inflammation. These important elements of human milk support…

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Mammary Epithelium Permeability, Lactation Outcomes, and Infant Health — UNIVERSITY OF MASSACHUSETTS AMHERST | UNITED ST | Dev Procure