grant
Magnetic Resonance Imaging of Outbred Rats with Variable Vulnerability to Compulsive Alcohol Use
Organization UNIVERSITY OF CALIFORNIA, SAN DIEGOLocation LA JOLLA, UNITED STATESPosted 20 Sept 2025Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY2025AbstinenceAcuteAddressAgeAlcohol Chemical ClassAlcohol DrinkingAlcohol consumptionAlcohol dependenceAlcoholsAnimalsBehaviorBerryBrainBrain DiseasesBrain DisordersBrain Nervous SystemBrain imagingCausalityCell BodyCell Communication and SignalingCell SignalingCellsChronicClassificationCollaborationsCommon Rat StrainsComplementComplement ProteinsComplexDWI (diffusion weighted imaging)DWI-MRIData SetDevelopmentDifferences between sexesDiffers between sexesDiffusionDiffusion MRIDiffusion Magnetic Resonance ImagingDiffusion Weighted MRIDiffusion weighted imagingDiffusion-weighted Magnetic Resonance ImagingDiseaseDisorderEmotionalEncephalonEncephalon DiseasesEnvironmentEtOH drinkingEtOH useEtiologyExhibitsFemaleFunctional MRIFunctional Magnetic Resonance ImagingFundingGenerationsGeneticGenetic DiversityGenetic VariationGenomeGenomicsGenotypeGoalsHarvestHeterogeneityHumanImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodIndividualIndividual DifferencesIntracellular Communication and SignalingIntracranial CNS DisordersIntracranial Central Nervous System DisordersInvestigationLightMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMeasurementMeasuresMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMicroscopicMicroscopyModelingModern ManNIAAANMR ImagingNMR TomographyNational Institute on Alcohol Abuse and AlcoholismNerve CellsNerve UnitNeural CellNeurocyteNeuronsNeurosciencesNuclear Magnetic Resonance ImagingPhenotypePhotoradiationPopulationPopulation HeterogeneityPredispositionPreventionPublic HealthRatRats MammalsRattusResearchResearch ResourcesResolutionResourcesRewardsRodent ModelSample SizeSelf AdministeredSelf AdministrationSeveritiesSex DifferencesSexual differencesSignal TransductionSignal Transduction SystemsSignalingSourceSpecialistStandardizationStressStructureSusceptibilitySystematicsTimeTranslatingTranslationsVulnerable PopulationsWithdrawalWorkZeugmatographyaddictionaddictive disorderagesalcohol addictionalcohol dependencyalcohol dependentalcohol exposedalcohol exposurealcohol ingestionalcohol intakealcohol product usealcohol related problemalcohol usealcohol use disorderalcoholic beverage consumptionalcoholic drink intakebiobankbiological signal transductionbiorepositorybrain visualizationcausationchronic EtOH drinkingchronic alcohol consumptionchronic alcohol drinkingchronic alcohol ingestionchronic alcohol usechronic ethanol consumptionchronic ethanol drinkingchronic ethanol ingestionclinical relevanceclinically relevantcohortcomplementationdMRIdensitydevelopmentaldiffuseddiffusesdiffusingdiffusion tensor imagingdiffusionsdisabilitydisease causationdiverse populationsethanol consumptionethanol drinkingethanol exposedethanol exposureethanol ingestionethanol intakeethanol product useethanol useethanol use disorderexecutive controlexecutive functionexposed to alcoholexposed to ethanolexposure to alcoholexposure to ethanolfMRIheterogeneous populationhuman modelimaging studyimprovedincentive salienceindividual heterogeneityindividual variabilityindividual variationindividualized strategiesinsightlongitudinal imagingmodel of humannerve cell deathnerve cell lossneural adaptationneural imagingneuro-imagingneuroadaptationneuroimagingneurological imagingneuron cell deathneuron cell lossneuron deathneuron lossneuronalneuronal cell deathneuronal cell lossneuronal deathneuronal lossnew markernovelnovel biomarkernovel markerpersonalization of treatmentpersonalized medicinepersonalized strategiespersonalized therapypersonalized treatmentpopulation diversitypre-clinicalpre-clinical imagingpreclinicalpreclinical imagingpreventpreventingresilienceresilientresolutionsresponseserial imagingsex based differencessex-dependent differencessex-related differencessex-specific differencestranslationtreatment strategyvaporvulnerable groupvulnerable individualvulnerable people♀
Description preview
PROJECT SUMMARY/ABSTRACT
Advancements in neuroscience, including magnetic resonance imaging (MRI), have significantly improved our
understanding of alcohol use disorder (AUD) and brain function, yet due to the heterogeneity in the disorder
and complexity of the brain, controlled comprehensive approaches in diverse populations are a necessity to…
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