grant
Magnetic resonance imaging methods to capture tolerogenic cell therapy fate in preclinical and ex vivo human transplant models
Organization UNIVERSITY OF CALIFORNIA, SAN DIEGOLocation LA JOLLA, UNITED STATESPosted 1 May 2026Deadline 31 Mar 2030
NIHUS FederalResearch GrantFY2026AccelerationAcuteAdoptionAdoptive TransferAdverse effectsAnimal ModelAnimal Models and Related StudiesAnti-Rejection TherapyAutoimmune DiseasesAutoimmune StatusAutoimmunityBehaviorBiological MarkersBloodBlood Reticuloendothelial SystemBlood VesselsBody TissuesCD25Cardiac ToxicityCardiac TransplantationCardiotoxicCardiotoxicityCell BodyCell FunctionCell IsolationCell PhysiologyCell ProcessCell SegregationCell SeparationCell Separation TechnologyCell SurvivalCell TherapyCell ViabilityCellsCellular FunctionCellular PhysiologyCellular ProcessCellular injuryChronicClinicalContrast AgentContrast DrugsContrast MediaDendritic CellsDermatoplastiesDermatoplastyDiabetes MellitusEngineeringEquilibriumEvaluationFe oxideFluorine CompoundsGoalsGraft RejectionGraft SurvivalGraft ToleranceGrafting ProcedureH+ elementHeartHeart GraftingHeart TransplantationHistopathologyHomingHumanHydrogen IonsIL2RIL2RAIL2RA geneImageImmuneImmune ToleranceImmunesImmunologic ToleranceImmunomodulationImmunosuppressionImmunosuppression EffectImmunosuppressive EffectImmunosuppressive TherapyImpairmentIndividualInfusionInfusion PumpsInfusion proceduresInfusorsIntravenousLabelLegal patentLeukapheresisLeukocytapheresisMR ImagingMR TomographyMRIMRIsMacrophageMagnetic Resonance ImagingMagnetismMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMethodsMiceMice MammalsMicrobeadsMicrospheresModelingModern ManMonitorMorbidityMurineMusMφNMR ImagingNMR TomographyNephrotoxicNuclear Magnetic Resonance ImagingOncologyOncology CancerOrganOrgan DonorOrgan ModelOrgan TransplantationOrgan TransplantsOutcomePatentsPatient CarePatient Care DeliveryPatientsPatternPerfusionPerfusion PumpsPhenotypePositionPositioning AttributeProceduresProcessProtocolProtocols documentationProtonsQOLQuality of lifeRadiationRadiopaque MediaRegenerative MedicineRegimenRegulatory T-LymphocyteRegulatory approvalRiskSensitivity and SpecificitySkinSkin TransplantationSkin graftSolidSubcellular ProcessT cell based immune therapyT cell based therapeuticsT cell based therapyT cell directed therapiesT cell immune therapyT cell immunotherapyT cell targeted therapeuticsT cell therapyT cell treatmentT cell-based immunotherapyT cell-based treatmentT cellular immunotherapyT cellular therapyT lymphocyte based immunotherapyT lymphocyte based therapyT lymphocyte therapeuticT lymphocyte treatmentT-CellsT-LymphocyteT-cell therapeuticsT-cell transfer therapyTCGFRTherapeuticTherapeutic LeukopheresisTherapeutic immunosuppressionTimeTissuesToxic effectToxicitiesTransfectionTranslationsTransplant RejectionTransplantationTransplantation RejectionTreatment EfficacyTreatment FailureTreatment-related toxicityTregUnited StatesVeiled CellsVisualizationWorkZeugmatographyadoptive T cell transferadoptive T lymphocyte transferadoptive T-cell therapyallogenic skin graftallograft rejectionartificial immunosuppressionautoimmune conditionautoimmune disorderautoimmunity diseasebalancebalance functionbio-markersbiologic markerbiomarkercardiac graftcare for patientscare of patientscaring for patientscell based interventioncell behaviorcell damagecell injurycell mediated interventioncell mediated therapiescell sortingcell-based therapeuticcell-based therapycellular behaviorcellular damagecellular therapeuticcellular therapyclinical relevanceclinical translationclinically relevantclinically translatablecolcotharcytokinedamage to cellsdiabetesend-stage organ failureexperienceferric oxideheart transplanthigh resolution imaginghistologic stainshistological stainsimage guidanceimage guidedimage-based methodimagingimaging methodimaging modalityimmune modulating strategyimmune modulationimmune modulatory strategyimmune regulationimmune suppressionimmune suppressive activityimmune suppressive functionimmune system toleranceimmune unresponsivenessimmunologic reactivity controlimmunological paralysisimmunomodulatoryimmunomodulatory strategyimmunoregulationimmunoregulatoryimmunosuppression therapyimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseimprovedin vivoinfusionsinjury to cellsinsightintervention efficacyiron oxidekidney toxicitylongitudinal imagingmagneticmodel of animalmouse modelmurine modelnephrotoxicityorgan allograftorgan graftorgan xenograftpost-transplantpost-transplantationposttransplantposttransplantationpre-clinicalpreclinicalpreventpreventingreal time monitoringrealtime monitoringred iron oxideregulatory T-cellsregulatory authorizationregulatory certificationregulatory clearanceserial imagingsystemic toxicitytherapeutic T-cell platformtherapeutic efficacytherapeutic toxicitytherapy associated toxicitytherapy efficacytherapy failuretherapy optimizationtherapy related toxicitytherapy toxicitythymus derived lymphocytetooltraffickingtranslationtransplanttransplant modeltransplant therapytransplant treatmenttransplantation therapytransplantation treatmenttreatment optimizationtreatment toxicitytreatment-associated toxicityvascular
Description preview
ABSTRACT
Solid organ transplantation has transformed care for patients with end-stage organ failure, dramatically improving
survival and quality of life. In 2024, over 48,000 transplants were performed in the United States. Despite
advances in immunosuppressive regimens, allograft rejection remains a major barrier to long-term graft survival,
with…
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