grant
Machine learning of biomolecular interactions and the human signaling networks they comprise
Organization COLUMBIA UNIVERSITY HEALTH SCIENCESLocation NEW YORK, UNITED STATESPosted 22 Sept 2023Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY2025AddressAffinityAllelesAllelomorphsAmino Acid SequenceBiologicalCell BodyCell Communication and SignalingCell SignalingCellsChemicalsCollaborationsComputational toolkitComputer ModelsComputerized ModelsDNA mutationDiseaseDisorderGenetic ChangeGenetic DiseasesGenetic defectGenetic mutationGenomeHumanHuman BiologyIndividualInformation NetworksIntracellular Communication and SignalingLanguageLearningLigand BindingLigandsMachine LearningMapsModelingModern ManMutationNHLBINational Heart, Lung, and Blood InstitutePathogenicityPathway interactionsPersonsPopulationPrimary Protein StructurePropertyProtein ConformationProteinsProteomeResearchSignal TransductionSignal Transduction SystemsSignalingStructureSystems BiologyTOPMedTechniquesTestingTrans-Omics for Precision MedicineVariantVariationbiobankbiologicbiological signal transductionbiorepositorycomputational modelingcomputational modelscomputational toolboxcomputational toolscomputational toolsetcomputer based modelscomputer based predictioncomputerized modelingcomputerized toolsdeep learningdeep learning methoddeep learning strategyexomegenetic analysisgenetic conditiongenetic disordergenome mutationgenomic datagenomic datasethuman diseaseinformation processingmachine based learningmachine learning based modelmachine learning modelmath learningmathematical learningmathematics learningpathwaypredictive modelingprogramsprotein protein interactionprotein sequenceprotein structure predictionsynergismtrait
Description preview
My lab will use machine learning to build physically-grounded models of biomolecules and their interactions and
apply these models at proteome (genome) scale to address basic questions in the systems biology of human
signaling. On the modeling front, our efforts will focus on building computational models of protein-ligand
interactions, with a…
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