grant
Lysosomal membrane dynamics during stress
Organization OHIO STATE UNIVERSITYLocation Columbus, UNITED STATESPosted 1 Feb 2025Deadline 31 Jan 2030
NIHUS FederalResearch GrantFY2026AnnexinsAutophagocytosisAutoregulationBinding ProteinsBiologyC-jun Amino-Terminal KinaseC-jun Kinase-1C-jun N-Terminal Kinase 1CalcimedinsCell BodyCell Communication and SignalingCell DeathCell FunctionCell PhysiologyCell ProcessCell SignalingCellsCellular FunctionCellular PhysiologyCellular ProcessComprehensionCrohn diseaseCrohn'sCrohn's diseaseCrohn's disorderCytosolDNA mutationDestinationsDiseaseDisorderDysfunctionFunctional disorderGenetic ChangeGenetic defectGenetic mutationGranulomatous EnteritisH+ elementHansen's DiseaseHealthHomeostasisHumanHydrogen IonsHydrolaseHydrolase Family GeneHydrolase GeneImmuneImmunesIntracellular Communication and SignalingJN KinaseJNKJNK Mitogen-Activated Protein KinasesJNK1JNK1 KinaseJNK1 proteinJNK1A2JNK21B1/2KinasesLRRK2LRRK2 geneLRRK2 leucine-rich repeat kinase 2 geneLRRK2 proteinLeftLeprosyLigand Binding ProteinLigand Binding Protein GeneLipocortinsLysosomesM tuberculosis infectionM. tb infectionM. tuberculosis infectionM.tb infectionM.tuberculosis infectionMAP Kinase 8MAP Kinase 8 GeneMAPK8MAPK8 Mitogen-Activated Protein KinaseMAPK8 geneMTB infectionMacrophageMembraneMicroscopyMitogen-Activated Protein Kinase 8Modern ManMolecularMotorMutationMycobacterium tuberculosis (MTB) infectionMycobacterium tuberculosis infectionMφNamesNerve DegenerationNervous System DiseasesNervous System DisorderNeurologic DisordersNeurological DisordersNeuron DegenerationOrganellesOutcomePARK8 proteinPRKM8Paralysis AgitansParkinsonParkinson DiseaseParkinson disease 8 proteinPathway interactionsPhosphorylationPhosphotransferase GenePhosphotransferasesPhysiological HomeostasisPhysiopathologyPlayPrimary ParkinsonismProcessProgressive Supranuclear OphthalmoplegiaProgressive Supranuclear PalsyProtein BindingProtein PhosphorylationProteinsProteomicsProtonsQuality ControlRecyclingRoleRuptureSAP Kinase-1SAPK/JNKSAPK1 Mitogen-Activated Protein KinaseSAPK1/JNKShapesSignal TransductionSignal Transduction SystemsSignalingSortingSteele-Richardson-Olszewski DiseaseSteele-Richardson-Olszewski SyndromeStressStress-Activated Protein Kinase JNK1Stress-Activated Protein Kinase gammaSubcellular ProcessTB infectionTherapeuticTherapeutic InterventionTransphosphorylasesTuberculosisVesicleautophagybiological signal transductionbound proteinc-jun N-Terminal Kinasecell typedardarindardarin genedardarin proteindisseminated TBdisseminated tuberculosiseleocolitisgenome mutationhuman diseaseiPSiPSCiPSCsinduced pluripotent cellinduced pluripotent stem cellinducible pluripotent cellinducible pluripotent stem cellinfection due to Mycobacterium tuberculosisinsightintervention therapyjun-NH2-Terminal Kinaseleucine-rich repeat kinase 2lipidomicsmembrane structurenamenamednamingnecrocytosisneural degenerationneurodegenerationneurodegenerativeneurological degenerationneurological diseaseneuronal degenerationnovelpathophysiologypathwaypreventpreventingrab G-Proteinsrab GTP-Binding Proteinsrab GTPasesrecruitregional enteritisrepairrepairedresponsesocial rolestress-activated protein kinase 1tuberculosis infectiontuberculous spondyloarthropathy
Description preview
ABSTRACT
Lysosomes are round-shaped acidic organelles full of hydrolases. They play multiple roles within the cell,
including degradation, recycling, or signaling. Notably, lysosomal damage is a hallmark in various human
diseases, including lysosomal storage disorders, neurodegeneration, and immune-related diseases. A
prevalent outcome of…
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