grant
Lymphatic drainage dysfunction in chronic hypertension
NIHUS FederalResearch GrantFY2025AccelerationAccessory SinusesAddressAffectAge MonthsAgingAmentiaAmlodipineAnatomic SitesAnatomic structuresAnatomyAnimalsAnti-Hypertensive AgentsAnti-Hypertensive DrugsAnti-HypertensivesApoplexyArteriesAttentionBiochemicalBlood VesselsBrainBrain DrainsBrain Nervous SystemBrain Vascular AccidentCNS lymphatic systemCalciumCerebral StrokeCerebral small vessel diseaseCerebrovascular ApoplexyCerebrovascular StrokeCerebrumCervicalCervical Lymph NodeCervical lymph node groupChronicClinicalCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalCollagenCommon Rat StrainsComputer AnalysisCoupledCouplingDataDeep Cervical Lymph NodeDefectDementiaDepositDepositionDevelopmentDiseaseDisorderDisturbance in cognitionDrainageDrainage procedureDrugsDysfunctionEncephalonFLT4 LigandFLT4-LFluid BalanceFluid HomeostasisFluorescence Light MicroscopyFluorescence MicroscopyFunctional disorderFunctional impairmentGlymphatic impairmentGlymphatic system dysfunctionGlymphatic system impairmentGoalsHealthHypertensionHypotensive AgentHypotensive DrugsImageImmune SurveillanceImmunologic SurveillanceImmunosurveillanceImpaired cognitionImpairmentInbred WKY RatsIntercellular FluidInterstitial FluidsInvestigatorsLightLinkLiquid substanceLymph Node Reticuloendothelial SystemLymph SystemLymph node properLymphaticLymphatic DiseasesLymphatic NetworkLymphatic SystemLymphatic System Reticuloendothelial SystemLymphatic functionLymphatic nodesMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMapsMeasuresMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMedicationMeningeal circuitMeningeal lymphatic networkMeningeal lymphatic pathwayMeningeal lymphatic systemMeningeal lymphaticsModelingMolecularNMR ImagingNMR TomographyNasal SinusesNasal cavity/ParanasalNasal cavity/Paranasal sinusesNerve DegenerationNeuron DegenerationNodalNuclear Magnetic Resonance ImagingOutcomeParanasal SinusesPathogenesisPathologicPathologyPathway interactionsPatientsPersonsPharmaceutical PreparationsPhotoradiationPhysiologicPhysiologicalPhysiopathologyPlayProteomicsRatRat StrainsRats MammalsRattusResearch PersonnelResearchersRoleSeriesSinusStrokeSystemTechniquesTestingTherapeuticTimeVEGF-CVascular Cognitive ImpairmentVascular Endothelial Growth Factor CVascular Endothelial Growth Factor Related ProteinVascular Hypertensive DiseaseVascular Hypertensive DisorderWKY RatsWistar Kyoto RatsWorkZeugmatographyaged groupaged groupsaged individualaged individualsaged peopleaged personaged personsaged populationaged populationsaging populationanti-hypertensionblood pressure elevationbrain attackbrain lymph systembrain lymphatic systemcerebralcerebral small vessel disordercerebral vascular accidentcerebrovascular accidentcerebrovascular contribution to cognitive impairmentcerebrovascular contributions to cognitive dysfunctioncognitive dysfunctioncognitive losscomputational analysescomputational analysiscomputer analysesdesigndesigningdevelopmentaldisease modeldisorder modeldraining lymph nodedrug/agentelevated blood pressureexperimentexperimental researchexperimental studyexperimentsfluidfunctional statusgain of functionglia lymphatic circuitglia-lymphatic systemglial lymphatic systemglialymphatic circuitglialymphatic networkglialymphatic pathwayglialymphatic systemglymphatic clearance pathwayglymphatic dysfunctionglymphatic functionglymphatic pathwayglymphatic systemglymphatic-lymphatic systemglymphaticshigh blood pressurehyperpiesiahyperpiesishypertensivehypertensive diseasehypertensive disorderimagingimaging approachimaging based approachincrease in blood pressureincreased blood pressureliquidlymph channellymph glandlymph nodeslymph vessellymphatic channellymphatic disorderlymphatic drainagelymphatic dysfunctionlymphatic impairmentlymphatic vasculaturelymphatic vessellymphnodesmolecular biomarkermolecular markerneural degenerationneurodegenerationneurodegenerativeneurological degenerationneuronal degenerationnormotensivenovelparavascular systempathophysiologypathwaypopulation agingregional lymph nodesocial rolestrokedstrokestoolvascularvascular and cognitive impairmentvascular cognition impairmentvascular cognitive declinevascular cognitive diseasevascular cognitive disordervascular cognitive dysfunctionvascular contributions to cognitive declinevascular contributions to cognitive impairmentvascular disease and impaired cognitionvascular dysfunction resulting in cognitive declinevascular related cognitive declinevascular related cognitive impairmentwasting
Description preview
Abstract
Malfunction of the brain’s waste clearing glymphatic system has been shown to play a key role in cerebral small
vessel disease the most common cause of vascular cognitive impairment prevalent with chronic hypertension in
the aging population. Cerebral small vessel disease (cSVD) affects 750 million people worldwide, causes up to
45% of…
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