grant
Lymph node stromal senescence and transplant immunity
Organization BRIGHAM AND WOMEN'S HOSPITALLocation BOSTON, UNITED STATESPosted 3 May 2024Deadline 31 Mar 2029
NIHUS FederalResearch GrantFY2025AgingAgonistAlloantigenAntsB blood cellsB cellB cellsB-CellsB-LymphocytesB-cellCD154CD40LCD40LGCDK Inhibitor ProteinCDK4ICDKI ProteinCDKN2CDKN2 GenesCDKN2ACDKN2A geneCMM2Cardiac TransplantationCaringCell AgingCell BodyCell SenescenceCell TherapyCell-Extracellular MatrixCellsCellular AgingCellular SenescenceChemotactic CytokinesChief CellCicatrixClinical Treatment MoabCollagenCyclin Kinase InhibitorCyclin-Dependent Kinase InhibitorCyclin-Dependent Kinase Inhibitor 2A GeneDataDeath RateDendritic CellsDevelopmentDown-RegulationDrugsECMEffector CellElderlyEndothelial CellsEnhancersEquilibriumExtracellular MatrixFiberGeneHomologGenerationsGenesGrafting ProcedureHeart GraftingHeart TransplantationHomingHomologHomologous Chemotactic CytokinesHomologous GeneHomologueHumanINK4INK4AImmuneImmune ToleranceImmunesImmunityImmunologic ToleranceImmunomodulationIn VitroIncidenceInflammatoryInjectionsIntercrinesKO miceKnock-out MiceKnockout MiceLymph Node Reticuloendothelial SystemLymph node properLymphatic TissueLymphatic nodesLymphoid TissueLymphotoxinLymphotoxin ALymphotoxin-alphaLymphotoxin-αMTS1MTS1 GenesMediatingMedicationMember 1 TNF SuperfamilyMiceMice MammalsModelingModern ManMonitorMonoclonal AntibodiesMurineMusMyofibroblastNanodeliveryNull MouseOlder PopulationOrgan TransplantationOrgan TransplantsOrgan failureOutcomePathogenesisPathway interactionsPatientsPharmaceutical PreparationsPlayPolycombPopulationPositionPositioning AttributeProteinsReceptor SignalingRegulatory T-LymphocyteRejuvenationReplicative SenescenceReporterResearchResistanceReticular CellRoleSIS cytokinesScarsSolidStromal CellsStromal ChangeT-CellsT-LymphocyteTNF-bTNF-betaTNF-βTNFSF1TNFSF5TNFSF5 geneTNFβTP16TRAP GeneTSG9ATeff cellTestingTimeTransplant RecipientsTransplantationTransplantation ToleranceTregTumor Necrosis Factor-BetaTumor Necrosis Factor-βVeiled CellsWaiting Listsadvanced ageage associatedage associated alterationsage associated changesage correlatedage correlated alterationsage correlated changesage dependentage dependent alterationsage dependent changesage induced alterationsage induced changesage linkedage relatedage related alterationsage related changesage specificage specific alterationsage specific changesagedaged miceaged mouseaging associatedaging associated alterationsaging associated changesaging correlated alterationsaging correlated changesaging dependent alterationsaging dependent changesaging induced alterationsaging induced changesaging relatedaging related alterationsaging related changesaging specific alterationsaging specific changesalloimmunityalterations with agebalancebalance functioncardiac allograftcardiac graftcell based interventioncell mediated interventioncell mediated therapiescell transformationcell-based therapeuticcell-based therapycellular therapeuticcellular therapychanges with agechemoattractant cytokinechemokineconditional knock-outconditional knockoutdemographicsdevelopmentaldrug/agenteffector T cellelderly miceexperienceexperimentexperimental researchexperimental studyexperimentsgeriatricglobal gene expressionglobal transcription profileheart allograftheart transplantimmune modulationimmune regulationimmune system toleranceimmune unresponsivenessimmunologic reactivity controlimmunological paralysisimmunomodulatoryimmunoregulationimmunoregulatoryimprovedinflammatory environmentinflammatory milieuinhibitorinnovateinnovationinnovativeisoimmunitylymph glandlymph node microenvironmentlymph nodeslymphnodeslymphotoxin beta receptorlymphotoxin β receptorlymphotoxin-beta-specific receptormAbsmetabolism measurementmetabolomicsmetabonomicsmonoclonal Absmortality ratemortality rationew approachesnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeuticsnew therapynew therapy approachesnew treatment approachnew treatment strategynext generation therapeuticsnovelnovel approachesnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel strategiesnovel strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeuticsnovel therapynovel therapy approachold miceolder adultolder adulthoodolder groupsolder individualsolder personorgan allograftorgan graftorgan xenograftp14ARFp16 Genesp16INK4 Genesp16INK4A Genesp16INK4apathwayprogramsregulatory T-cellsreplicative agingresistantresponsescaffoldscaffoldingsenescencesenescence and its associated secretory phenotypesenescence associated secretomesenescence associated secretory factorssenescence associated secretory pathwaysenescence associated secretory phenotypesenescence associated secretory programsenescence associated secretory proteinssenescentsenescent associated secretomesenescent associated secretory phenotypesenior citizensingle cell genomicssite targeted deliverysocial roletargeted deliverythymus derived lymphocytetraffickingtranscriptometransformed cellstransplanttransplant patienttrendwaitlist
Description preview
Abstract
The steadily increasing elderly population and its rising incidence of organ failure have led to a burgeoning
number of aged patients on the waitlist for solid organ transplants. Lymph nodes (LNs) play a critical role in
controlling alloimmune responses and formation of immune tolerance to transplantation under costimulatory
blockade. LN…
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