grant
Lymph Node Stromal Cells in the Pathogenesis, Diagnosis, and Treatment of Unicentric Castleman Disease
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 15 Aug 2025Deadline 31 Jul 2030
NIHUS FederalResearch GrantFY2025AFLHAffectAngiofollicular Lymphoid HyperplasiaAngiolymphoid hyperplasiaAppearanceAutoimmune DiseasesAutoimmune StatusAutoimmunityB-Cell Attracting Chemokine 1B-Lymphocyte ChemoattractantBCA1BLC geneBLC proteinBioinformaticsBlood DiseasesBody TissuesCD140BCXCL13CXCL13 geneCancersCareer Development AwardsCareer Development Awards and ProgramsCareer Development Programs K-SeriesCaringCastleman DiseaseCastleman's TumorCausalityCell BodyCell Communication and SignalingCell CompartmentationCell CompartmentationsCell SignalingCellsCharacteristicsChemokine, CXC Motif, Ligand 13Chemotactic CytokinesClonal ExpansionClonalityConstitutional FindingConstitutional SymptomCryofixationCryopreservationDNA mutationDataDevelopment and ResearchDiagnosisDiagnosticDiseaseDisorderEnlarged SpleenEnlargement of lymph nodesEtiologyEuropeanFibroblastsFoundationsFundingFutureGLNHGene ExpressionGene TranscriptionGenesGeneticGenetic ChangeGenetic TranscriptionGenetic defectGenetic mutationGenetic studyGenotypeGerminoblastic SarcomaGerminoblastomaGiant Lymph Node HyperplasiaGoalsHealthHematologic DiseasesHematological DiseaseHematological DisorderHistologicHistologicallyHistologyHomologous Chemotactic CytokinesHost DefenseHumanIL-6 inhibitorIL6 inhibitorImmunologyIn VitroInfectionInflammatoryIntercrinesInterleukin-6 inhibitorIntracellular Communication and SignalingInvestigationInvestigatorsJTK12JournalsK-AwardsK-Series Research Career ProgramsKinasesLaboratoriesLifeLocationLymph Node Reticuloendothelial SystemLymph node properLymphatic TissueLymphatic cellLymphatic nodesLymphocyteLymphocyte ImmunophenotypingsLymphocyticLymphoid TissueLymphomaLymphoproliferative DisordersMagazineMalignantMalignant - descriptorMalignant LymphomaMalignant NeoplasmsMalignant TumorMediatingMediatorMedicineMentorsMentorshipMiceMice MammalsModelingModern ManMosaicismMulticentric Angiofollicular Lymphoid HyperplasiaMulticentric Castleman's DiseaseMurineMusMutationMyofibroblastOutcomePDGF-R-BetaPDGFRPDGFR1PDGFRBPDGFRB genePathogenesisPathogenicityPatientsPatternPhosphotransferase GenePhosphotransferasesPhysiciansPlayPopulationPositionPositioning AttributePrevalenceProductionPublicationsR & DR&DRNA ExpressionResearchResearch Career ProgramResearch PersonnelResearchersReticulolymphosarcomaRoleSCYB13SIS cytokinesScientific PublicationScientistSignal TransductionSignal Transduction SystemsSignalingSmall Inducible Cytokine Subfamily B, Member 13Somatic MutationSpecificitySplenomegalyStromal CellsTechnical ExpertiseTechniquesTestingTissuesTrainingTranscriptionTransphosphorylasesWorkalloimmunityautoimmune conditionautoimmune disorderautoimmunity diseasebiobankbiological signal transductionbiorepositoryblood disordercareercareer developmentcausationchemoattractant cytokinechemokinecohortcold preservationcold storagecytokinediagnostic tooldisease causationdisease diagnosisexperiencegenome mutationglobal gene expressionglobal transcription profilehuman diseasehuman tissueimmunohistochemical biomarkersimmunohistochemical markersimprovedinhibit IL-6inhibit IL6inhibit Interleukin-6inhibitorinsightinstructorisoimmunitylife spanlifespanlymph celllymph glandlymph nodeslymphnodeslymphoproliferative diseasemalignancymortalitymosaic diseasesmosaic disordersmulticastleman's diseasesmutantneoplasm/cancernew diagnosticsnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation diagnosticsnext generation therapeuticsnovel diagnosticsnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyprofessorresearch and developmentskillssocial rolesomatic variantspatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicstechnical skillstooltranscriptometranscriptomics
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Project Summary/Abstract
The goal of the proposed five-year training plan is to provide the foundation for an independent, R01-funded
research career as an academic physician-scientist studying the impact of lymphoid tissue stromal cells on
human health and disease. I am an Instructor of Medicine with a plan to promotion to Assistant Professor in…
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