grant

Low-Profile 3D-Printed Radiopaque Bioresorbable Vascular Scaffolds

Organization NORTHWESTERN UNIVERSITYLocation Chicago, UNITED STATESPosted 1 Jan 2019Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY20253-D print3-D printer3D Print3D printer3D printingASCVDAbsorbable ImplantsAdvanced DevelopmentAntioxidantsArteriesAtherosclerosisAtherosclerotic Cardiovascular DiseaseBioabsorbable ImplantsBiocompatible MaterialsBiodegradable ImplantsBiomaterialsBlood VesselsBlood flowBody TissuesCardiacCardiac arteryCardiologyCardiovascularCardiovascular Body SystemCardiovascular Organ SystemCardiovascular systemCathetersCitratesClinicalClinical ResearchClinical StudyClottingCoagulationCoagulation ProcessCollaborationsContrast AgentContrast DrugsContrast MediaCoronary ArteriosclerosisCoronary Artery DiseaseCoronary Artery DisorderCoronary AtherosclerosisCoronary arteryDataDevicesDiabetes MellitusDiameterDimensionsDomestic PigDrug DeliveryDrug Delivery SystemsDrugsEndotheliumEnsureEpidemicEventFDA approvedFamily suidaeFluoroscopyGoalsHealth Care CostsHealth CostsHeart VascularHeart arteryHistopathologyHumanIn VitroIn vivo analysisIncidenceInflammationInflammatoryLiquid substanceManufacturerMarketingMeasurementMechanicsMedical DeviceMedicationMetabolic syndromeMetalsMethodologyMo elementModelingModern ManMolybdenumMorbidityMorbidity - disease rateMusculoskeletalOperative ProceduresOperative Surgical ProceduresOutcomePerformancePeripheral arterial diseasePersonsPharmaceutical PreparationsPigsPolymersProceduresProductionPropertyProtocolProtocols documentationRadiopaque MediaResearchResearch ContractsResearch ProposalsResidualResidual stateRiskSDZ RADSafetySecond LookSecond Look SurgeryStentsStructureSuidaeSurgicalSurgical InterventionsSurgical ProcedureSurgical RevisionSus scrofa domesticaSwineTechniquesTechnologyThickThicknessThrombosisTissuesTreatment outcomeVisualizationWithdrawalWorkabsorptionatheromatosisatherosclerotic coronary diseaseatherosclerotic diseaseatherosclerotic vascular diseasebiocompatibilitybiocompatible scaffoldbiodegradable polymerbiological materialbiomaterial compatibilitybioresorbable polymercirculatory systemcoronary arterial diseasecostdegradable polymerdesigndesigningdiabetesdrug standarddrug/agenteverolimusfabricationfabrication technologyfluidhuman diseaseimproved outcomein vivoin vivo evaluationin vivo testingiodixanolliquidmanufacturemanufacturing technologymechanicmechanicalmechanical propertiesmortalityperipheral artery diseasepig modelpiglet modelpolymerpolymericporcineporcine modelpreventpreventingrestenosisrevascularizationscaffoldscaffoldingscale upsuidsurgeryswine modelthree dimensional printingthrombogenesisthrombogenicitythromboticthrombotic diseasethrombotic disordertranslational impactultrasoundvascularvasomotion
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PROJECT SUMMARY
Atherosclerotic coronary artery disease (CAD) and peripheral artery disease (PAD) are responsible for

significant morbidity, mortality, and high healthcare costs in the USA. This problem will continue to grow due to

the diabetes epidemic as people with diabetes are at increased risk of developing atherosclerosis and less

likely to…

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Low-Profile 3D-Printed Radiopaque Bioresorbable Vascular Scaffolds — NORTHWESTERN UNIVERSITY | UNITED STATES | Jan 2019 | Dev Procure