grant
Longitudinal structure of spinal premotor circuits
Organization WASHINGTON UNIVERSITYLocation SAINT LOUIS, UNITED STATESPosted 15 Feb 2023Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY2026AblationAnimalsAnterior Horn CellsAnterior Horn NeuronsAssayAxonBehavioralBioassayBiologicalBiological AssayBrachydanio rerioChargeClinicalComputer ModelsComputerized ModelsContralateralDanio rerioDataEnhancer-Binding Protein GATA3EnsureExhibitsGATA-3 factorsGATA-3 proteinGATA-Binding Protein 3GATA3GATA3 geneGATA3 proteinGATA3 transcription factorHeadHomeHornsInjuryIpsilateralLegLocomotionLogicMammaliaMammalsMapsMeasuresMedulla SpinalisModelingMorphologyMotorMotor CellMotor NeuronsMovementMuscle Cell ContractionMuscle ContractionMuscular ContractionNatural regenerationNerve CellsNerve UnitNeural CellNeurocyteNeuronsOrganismOutputPatternPhysiologicPhysiologicalPopulationPositionPositioning AttributePublishingRegenerationSensorySliceSpinalSpinal CordStimulusStructureSynapsesSynapticSynaptic PotentialsTailTarget PopulationsTestingTranslatingV1 neuronVentral Horn CellsVentral Horn NeuronsVertebraeVertebralWalkingWhole-Cell RecordingsWorkZebra DanioZebra FishZebrafisharmbiologicbody movementcomputational modelingcomputational modelscomputer based modelscomputer based predictioncomputerized modelingdorsal hornexperimentexperimental researchexperimental studyexperimentshomesin vivoinhibitory neuroninjuriesliving systemmotoneuronneuronaloptogeneticspostsynapticpredictive modelingregeneratespinal cord repairspine bone structuresynapse
Description preview
Project Summary
As animals locomote, they constantly coordinate activity between the rostral and caudal ends of the body. This
coordination relies on neurons in the spinal cord that send long ascending or descending axonal projections.
Although several studies have shown that ablation of these neurons leads to deficits in coordination, it is…
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