grant
Longitudinal reciprocal relationships between cannabis use, sleep, and the HPA-axis
Organization OREGON HEALTH & SCIENCE UNIVERSITYLocation PORTLAND, UNITED STATESPosted 15 Jun 2025Deadline 30 Apr 2030
NIHUS FederalResearch GrantFY202618 year old18 years of age21 year old21 years of age21+ years old9-ene-TetrahydrocannabinolAcuteAddressAdultAdult HumanAeroseb-HCAffectAutomobile DrivingAutoregulationBedsBehavioralBloodBlood Reticuloendothelial SystemBlossomsCannabinoidsCannabisCetacortChronicCognition TherapyCognitive PsychotherapyCognitive TherapyCognitive treatmentCollectionComplexConsensusConsumptionCort-DomeCortefCortenemaCortisolCortisprayCortrilCross-Over DesignsCrossover DesignD9-tetrahydrocannabinolDelta-9-TetrahydrocannabinolDermacortDevicesDrug ToleranceEEGEcological momentary assessmentEldecortElectroencephalogramElectroencephalographyFlowersFrequenciesHPA axisHabitsHealthHigh PrevalenceHomeHomeostasisHydrocortisoneHydrocortoneHytoneIndividualInhalationInhalingInsomniaInsomnia DisorderIntoxicationLaboratoriesMaintenanceMeasurementMeasuresMediatingMediatorMethodsMotivationNREMNappingNeurobiologyNutracortOutcomeParticipantPathway interactionsPhonePhysiological HomeostasisPlant BloomsPolysomnographyProctocortProtocolProtocols documentationRandomizedRelapseReportingResearchRoleSafetySalivaSleepSleep DisordersSleep MonitoringSleep disturbancesSleeplessnessSmokeSomnographyStage 3 SleepStage III SleepSurvey InstrumentSurveysTHC co-useTHC useTelephoneTetrahydrocannabinolTetrahydrocannabinol co-useTetrahydrocannabinol useTimeVenousViscosityWithdrawal Symptomaberrant sleepactigraphactigraphyaddictionaddictive disorderadult youthadulthoodage 18age 18 yearsage 21age 21 yearsbiological adaptation to stresscannabis cessationcannabis legalizationcannabis usecannabis use disordercannabis usercognitive behavior interventioncognitive behavior modificationcognitive behavior therapycognitive behavioral interventioncognitive behavioral modificationcognitive behavioral therapycognitive behavioral treatmentdelta(1)-THCdelta(1)-Tetrahydrocannabinoldelta(9)-THCdelta(9)-Tetrahydrocannabinoldesigndesigningdisrupted sleepdisturbed sleepdrivingeighteen year oldeighteen years of agefall asleephomeshypothalamic-pituitary-adrenal (HPA) axishypothalamic-pituitary-adrenal axishypothalmus-pituitary-adrenal axisimpaired sleepimprovedimprovement on sleepirregular sleeplegal marijuanalegalized cannabislegalized marijuanamarijuana legalizationmarijuana usemarijuana use and disordermarijuana use disordermarijuana userneurobiologicalnew approachesnon rapid eye movementnon-REMnon-rapid eye movementnonREMnonrapid eye movementnovel approachesnovel strategiesnovel strategypathwaypoor sleepprimary outcomeprospectivequality of sleeprandomisationrandomizationrandomized control studyrandomized, controlled studyrandomly assignedreaction; crisisresponseside effectsleep behaviorsleep controlsleep diseasessleep disruptionsleep dysfunctionsleep dysregulationsleep habitsleep illnesssleep improvementsleep measurementsleep onsetsleep polysomnographysleep problemsleep qualitysleep regulationsleep/wake behaviorsleep/wake disruptionsleep/wake disturbancesleep/wake regulationsocial rolestress responsestress; reactiontargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttime usetrendtwenty-one year oldtwenty-one years of ageyoung adultyoung adult ageyoung adulthoodΔ(1)-THCΔ(1)-tetrahydrocannabinolΔ(9)-THCΔ(9)-tetrahydrocannabinolΔ-9-tetrahydrocannabinolΔ9-tetrahydrocannabinol
Description preview
Summary
Cannabis use disorder (CUD) affects at least 10% of the 193 million individuals that use cannabis worldwide.
Cannabis is frequently promoted as a sleep aid despite conclusive evidence to support such benefits. Further,
abrupt cessation of regular cannabis use is associated with sleep disturbances, often leading to reinitiating
cannabis…
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