grant
Longitudinal PET/MRI assessment of the pancreas in individuals at risk for and with recent onset type 1 diabetes
NIHUS FederalResearch GrantFY2026Acinar CellAciner CellsActivities of Daily LivingActivities of everyday lifeAffectAgeAntidiabetic HormoneArchitectureAutopsyAwardB9 endocrine pancreasBeta CellBindingBrittle Diabetes MellitusC-PeptideCell BodyCell FunctionCell PhysiologyCell ProcessCellsCellular FunctionCellular PhysiologyCellular ProcessChronicClinicalClinical MarkersClinical TrialsCommunitiesCyclic SomatostatinD-GlucoseDataDextroseDiabetes MellitusDiagnosisDiseaseDisorderDopamineDopamine ReceptorDysfunctionEndocrine PancreasEngineering / ArchitectureExocrine pancreasFunctional disorderGlucagonGlucoseGlukagonGoalsGrowth Hormone Inhibiting FactorsGrowth Hormone-Inhibiting HormoneHG-FactorHealthHeterogeneityHistologyHumulin RHydroxytyramineHyperglycemic-Glycogenolytic FactorIDDMImageIndividualInflammationInsulinInsulin CellInsulin ReceptorInsulin Receptor Protein-Tyrosine KinaseInsulin Secreting CellInsulin deficiencyInsulin-Dependent Diabetes MellitusInsulin-Dependent Tyrosine Protein KinaseIslands of LangerhansIslets of LangerhansJuvenile-Onset Diabetes MellitusKetosis-Prone Diabetes MellitusKnowledgeMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMeasurableMeasurementMeasuresMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMethodsModalityMolecularMolecular InteractionMonitorMorphologyNMR ImagingNMR TomographyNerve CellsNerve UnitNesidioblastsNeural CellNeurocyteNeuronsNovolin RNuclear Magnetic Resonance ImagingOGTTOral Glucose Tolerance TestOutcome MeasurePETPET ScanPET imagingPETSCANPETTPancreasPancreaticPancreatic IsletsPars endocrina pancreatisPathogenesisPatternPeptidesPersonsPhysiopathologyPositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyProinsulinQOLQOL improvementQuality of lifeRad.-PETReceptor ProteinRegular InsulinReportingResearchRiskSRIHSRIH-14Secretory GranulesSecretory VesiclesSocietiesSomatostatinSomatostatin-14Somatotropin Release Inhibiting FactorsSomatotropin Release-Inhibiting HormoneSpecific qualifier valueSpecifiedStaining methodStainsSubcellular ProcessSudden-Onset Diabetes MellitusT1 DMT1 diabetesT1DT1DMTechniquesTestingTimeTransplantationType 1 Diabetes MellitusType 1 diabetesType I Diabetes MellitusUnited StatesValidationVesicleVulnerable PopulationsZeugmatographyagesclinical biomarkersclinically useful biomarkerscohortconnecting peptidedaily living functiondaily living functionalitydiabeteseffective therapyeffective treatmentexocrine pancreaticfunctional abilityfunctional capacitygrowth hormone release inhibiting factorimage-based methodimagingimaging biomarkerimaging markerimaging methodimaging modalityimaging-based biological markerimaging-based biomarkerimaging-based markerimprovements in QOLimprovements in quality of lifein vivoindexinginsulin dependent diabetesinsulin dependent diabetes mellitus onsetinsulin dependent type 1insulin secretioninsulitisintervention designisletjuvenile diabetesjuvenile diabetes mellitusketosis prone diabetesmeasurable outcomenecropsyneuronalnon-diabeticnondiabeticoutcome measurementpancreas imagingpathophysiologypolypeptidepositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographypostmortempreservationprogramsquality of life improvementradioligandreceptorresponsesecondary outcometherapy designtransplanttreatment designtype 1 diabetes onsettype I diabetestype one diabetesuptakevalidationsvulnerable groupvulnerable individualvulnerable peopleβ-cellβ-cellsβCell
Description preview
PROJECT SUMMARY
Over 1 million people have type 1 diabetes in the United States and greatly affects their quality of life. In vivo
measurement of insulin vesicle functional capacity (IVFC) and beta cell mass (BCM) would allow tracking and
monitoring of recent advances in therapies designed to preserve IVFC and BCM and/or monitor transplanted
beta…
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