grant
Long-term multi-omics follow-up of the CALERIE Trial to generate new knowledge for geroscience
Organization COLUMBIA UNIVERSITY HEALTH SCIENCESLocation NEW YORK, UNITED STATESPosted 15 Jul 2019Deadline 31 Jan 2031
NIHUS FederalResearch GrantFY202621+ years oldAccelerationActive Follow-upAdipose tissueAdultAdult HumanAdvanced DevelopmentAgeAgingAlgorithmsAnimalsAssayAwardBasic ResearchBasic ScienceBenchmarkingBest Practice AnalysisBioassayBiologicalBiological AgingBiological AssayBiological FunctionBiological ProcessBiology of AgingBloodBlood Chemical AnalysesBlood Chemical AnalysisBlood PlasmaBlood Reticuloendothelial SystemBody SystemCaloric RestrictionCaloric TestsChronologyClinical TrialsDNA MethylationDataData BasesData CollectionData SetDatabasesDepositDepositionDeteriorationDietDiseaseDisorderElderlyEpidemiologyFaceFatty TissueFundingFutureGene Expression MonitoringGene Expression Pattern AnalysisGene Expression ProfilingGeroscienceGoalsGrimAge clockHannum clockHealthHorvath clockHumanIncidenceInterventionKnowledgeLaboratory AnimalsLifeLinkLong-term Follow-upMeasurementMeasuresMediatingMethodsModern ManMolecularMorbidityMultiomic DataMuscleMuscle TissueNational Institute of AgingNational Institute on AgingNon obeseNonobeseObservational StudyOnset of illnessOrganOrgan SystemOrganismParticipantPersonsPhenoAge clocksPlasmaPlasma SerumPopulationProcessProteomeProteomicsRandomization trialRandomizedRandomized, Controlled TrialsResearchReticuloendothelial System, Serum, PlasmaRunningSamplingSeriesSurrogate End PointsSurrogate EndpointSystemTestingTimeTranscript Expression AnalysesTranscript Expression AnalysisTranslatingactive followupadiposeadulthoodadvanced ageage associated diseaseage associated disorderage associated impairmentage clockage dependent diseaseage dependent disorderage dependent impairmentage related human diseaseage related pathwaysage-related diseaseage-related disorderage-related impairmentagesaging associated mechanismaging biological markeraging biomarkeraging clocksaging induced epigenetic changeaging markeraging mechanismaging pathwayaging processaging related mechanismaging related pathwaysaging-associated epigenetic changeaging-related epigenetic changeanalyze gene expressionbenchmarkbiobankbiologicbiological agebiological mechanism of agebiological pathways of agebiological process of agebiorepositoryblood chemistrycalorie restrictioncardiometaboliccardiometabolismclinical significanceclinically significantclock measuring biological ageclock measuring biological agingclock of biological agingcohortdata basedata harmonizationdata integrationdata resourcedata sharingdietsdisabilitydisease onsetdisorder onsetenhance healthspanepidemiologicepidemiologicalepigenetic age clocksepigenetic agingepigenetic clockepigenetic mechanisms in agingepigenetic modifications in agingepigenetic molecular clocksepigenetic regulation of agingexperimentexperimental researchexperimental studyexperimentsextend healthspanextending healthy lifespanfacesfacialfollow upfollow-upfollow-up investigationfollow-up researchfollowed upfollowupgene expression analysisgene expression assaygenomic biomarkergenomic datagenomic datasetgenomic markergeriatricgeroprotectantgeroprotectivegeroprotectorgeroscientificharmonized datahealthspanhealthspan extensionhealthy life spanimprove healthspanimprovedincrease healthspanintervention effectinvestigate follow-uplate in lifelate lifelater in lifelater lifelife spanlifespanliving systemlong-term followupmechanism regulating agingmechanisms involved in agingmethylation biomarkermethylation clockmethylation markermid lifemid-lifemiddle agemiddle agedmidlifemind/bodymolecular clockmultiomicsmultiple omic datamultiple omicsmuscularnew approachesnovel approachesnovel strategiesnovel strategyobservational research studyobservational surveypace of agingpace of biological agingpanomicspathway involved in agingpeerpost interventionpreventpreventingprolong healthspanpromote healthspanpublic data basepublic databasepublic health prioritiespublicly accessible data basepublicly accessible databasepublicly available data basepublicly available databaserandomisationrandomizationrandomized control trialrandomized trialrandomly assignedrate of agingrate of biological agingrate of changesenior citizenspeed of agingspeed of the agingstudy follow-upsurvey follow-uptargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttranscriptional profilingtranslation to humanswhite adipose tissueyellow adipose tissue
Description preview
SUMMARY
The graying global population makes interventions to extend healthy lifespan (healthspan) a public heath
priority. Therapies targeting basic biological processes of aging show proof-of-concept in animals: early-to-
midlife intervention can delay disease onset and prolong healthspan. But translating these geroprotective
therapies to humans…
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