grant
Long term impact of maternal opioid use and management strategies on neurodevelopment in rodent offspring
Organization WASHINGTON UNIVERSITYLocation SAINT LOUIS, UNITED STATESPosted 1 May 2026Deadline 28 Feb 2031
NIHUS FederalResearch GrantFY2026AbstinenceAdanonAlthoseAmmon HornAmygdalaAmygdaloid BodyAmygdaloid NucleusAmygdaloid structureAnatomic SitesAnatomic structuresAnatomyAnxietyBasal GangliaBasal NucleiBehaviorBehavioralBirthBrainBrain Nervous SystemBrain regionBuprenorphineCalciumCaringCell BodyCellsCells Placenta-TissueClinicalClinical DataClinical ResearchClinical StudyClinical TreatmentClinical TrialsCognitionConceptionsConvulsionsCornu AmmonisCorpus CallosumCorpus CallosumsDevelopmentDihydrohydroxycodeinoneDiseaseDisorderDolophineDoseDrugsEmotional DepressionEncephalonEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessExperimental ModelsExposure toFetal DeathFiberGeneralized GrowthGestationGoalsGrowthHippocampusHospital AdmissionHospitalizationHyperactivityImpairmentInfantInfant CareInfumorphKadianLactationLearningLengthLifeLong-Term EffectsMR ImagingMR TomographyMRIMRIsMS ContinMSirMagnetic Resonance ImagingMaintenanceMaintenance TherapyMeasuresMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMedicationMemory DeficitMemory impairmentMethadoneMethadoseMiceMice MammalsModelingMorphiaMorphineMurineMusNMR ImagingNMR TomographyNeonatal Abstinence SyndromeNeonatal Opioid Withdrawal SyndromeNeonatal Substance WithdrawalNeonatal Withdrawal SyndromeNeural DevelopmentNormal PlacentomaNuclear Magnetic Resonance ImagingNucleus AccumbensOpiate replacement therapyOpiate substitution therapyOpiate substitution treatmentOpiatesOpioidOpioid maintenance therapyOpioid maintenance treatmentOpioid replacement therapyOpioid replacement treatmentOpioid substitution therapyOpioid substitution treatmentOramorphOramorph SROutcomeOxycodeinonOxycodoneOxycodone SROxycontinParturitionPharmaceutical PreparationsPhotometryPlacentaPlacenta Embryonic TissuePlacentomePregnancyPregnant WomenPremature BirthPremature LaborPremature Obstetric LaborPrematurely deliveringPreterm BirthPreterm LaborProblem behaviorPsychological reinforcementReinforcementReplacement TherapyRewardsRiskRodentRodentiaRodents MammalsRoleRoxanolRoxicodoneSaccharoseSalineSaline SolutionSelf AdministeredSelf AdministrationSeveritiesSocioeconomic FactorsStatex SRStructureSublingual AdministrationSublingual Route of Drug AdministrationSublingual drug administrationSucroseSystemThalamic structureThalamusTissue GrowthTouchTouch sensationTreatment PeriodVentral Tegmental AreaWeaningWithdrawalZeugmatographyamygdaloid nuclear complexantagonismantagonistbaby carebehavior outcomebehavioral outcomebehavioral problembrain volumebuprenorphine treatmentclinical interventionclinical therapycognitive functiondepression symptomdepressivedepressive symptomsdevelopmentaldrug/agentepigeneticallyexpectant motherexpectant womenexpecting motherexpecting womenexposed in uterofetalfetal exposurefetal opiate exposuresfetal opioid exposurefetus deathgestational opiate exposuregestational opioid exposurehippocampalimprovedimproved outcomein uteroin utero exposureindividuals who are pregnantinfant health careinterpersonal competenceinterpersonal competencyintra-uterine environmental exposureintrauterine environmental exposurekappa opiatekappa opioidkappa opioid receptorslactatinglactationallongitudinal imagingmaternal opiates usematernal opioid usememory dysfunctionmethadone maintenancemethadone maintenance programmethadone maintenance therapymethadone maintenance treatmentmethadone treatmentmorphine administrationmouse modelmultiple substance usemultisubstance usemurine modelneonateneurobehavioralneurodevelopmentnewborn abstinence syndromenewborn careoffspringontogenyopiate exposureopiate use disorderopiate withdrawalopioid detoxopioid detoxificationopioid exposureopioid use disorderopioid withdrawaloptimal therapiesoptimal treatmentspain sensationpainful sensationpeople who are pregnantpoly substance usepolysubstance usepostnatalpre-clinicalpreclinicalpregnant femalespregnant motherspregnant peoplepregnant populationspremature childbirthpremature deliveryprenatal exposureprenatal opiate exposureprenatal opioid exposureprenatally exposedprenatally opiate exposedpreterm deliverypupreward processingserial imagingsocialsocial competencesocial competencysocial rolesocial skillssocio-economic factorsstandard of caresymptomatologytactile sensationthalamicthose who are pregnanttreatment daystreatment durationtreatment strategytrial regimentrial treatmentventral tegmentumwomen who are pregnantκ opiateκ opioidκ opioid receptorsκ-ORκOR
Description preview
Project Summary
The overall goal of this project is to evaluate the long-term impact of in utero oxycodone exposure, opioid
maintenance therapy and opioid-withdrawal mitigation strategies on neuro-behavioral development, brain
structure and volume and reward processing. Clinical studies have shown concerning long-term,
neurodevelopmental outcomes…
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