grant
Long-term effects of acute renal failure
Organization INDIANA UNIVERSITY INDIANAPOLISLocation INDIANAPOLIS, UNITED STATESPosted 1 Jul 2003Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY2025AcuteAcute Kidney FailureAcute Kidney InsufficiencyAcute Renal FailureAcute Renal InsufficiencyAdoptive TransferAffectAntigen-Presenting CellsAttenuatedB blood cellsB cellB cell differentiation factorB cell stimulating factor 2B cellsB-Cell Differentiation FactorB-Cell Differentiation Factor-2B-Cell Stimulatory Factor-2B-CellsB-LymphocytesB-cellBCDFBSF-2BSF2BiologicalBlood NeutrophilBlood Polymorphonuclear NeutrophilBlood VesselsBone-Derived Transforming Growth FactorCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCSF-1CTLA-8CTLA-8 GeneCTLA8CTLA8 GeneCalcium ChannelCalcium Channel Antagonist ReceptorCalcium Channel Blocker ReceptorsCalcium Ion ChannelsCell BodyCell Communication and SignalingCell DifferentiationCell Differentiation processCell FunctionCell PhysiologyCell ProcessCell SignalingCellsCellular FunctionCellular PhysiologyCellular ProcessChronic Kidney FailureChronic Renal DiseaseChronic Renal FailureColony-Stimulating Factor 1Common Rat StrainsComplexCytometryCytotoxic T-Lymphocyte-Associated Antigen 8Cytotoxic T-Lymphocyte-Associated Antigen 8 GeneCytotoxic T-Lymphocyte-Associated Serine Esterase 8Cytotoxic T-Lymphocyte-Associated Serine Esterase 8 GeneDataDependenceDevelopmentDisease ProgressionEctopic lymphoid organEctopic lymphoid structureExcessive salt consumptionExposure toExpression SignatureFDA approvedFibrosisGM-CSFGametesGene Expression ProfileGene TargetingGene TranscriptionGenetic TranscriptionGerm CellsGerm-Line CellsGoalsGranulocyte-Macrophage Colony-Stimulating FactorHPGFHepatocyte-Stimulating FactorHeterogeneityHistamine-Producing Cell-Stimulating FactorHospital AdmissionHospitalizationHumanHybridoma Growth FactorHypertensionIFN-beta 2IFNB2IL-1IL-17IL-17 GeneIL-17AIL-17A GeneIL-6IL1IL17IL17 ProteinIL17 geneIL17AIL17A GeneIL6 ProteinImmuneImmunesImpairmentInflammatoryInjuryInjury to KidneyInterleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8)Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8) GeneInterleukin 17 PrecursorInterleukin 17 Precursor GeneInterleukin IInterleukin-1Interleukin-17Interleukin-6Intracellular Communication and SignalingKidneyKidney DiseasesKidney Urinary SystemLong-Term EffectsLymphatic cellLymphocyteLymphocyte-Stimulating HormoneLymphocyticM-CSFMGI-2MacrophageMacrophage Cell FactorMacrophage Colony-Stimulating FactorMarrow NeutrophilMediatingMemoryMiceMice MammalsMilk Growth FactorModelingModern ManMolgramostinMurineMusMyeloid Differentiation-Inducing ProteinMφNatureNephropathyNeutrophilic GranulocyteNeutrophilic LeukocytePathogenicityPathway interactionsPhasePhenotypePhysiologicPhysiologicalPlasmacytoma Growth FactorPlatelet Transforming Growth FactorPlayPolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsPopulationPredisposing FactorPredispositionRNA ExpressionRatRats MammalsRattusReceptor ProteinRecoveryRegulationRegulatory PathwayRegulatory T-LymphocyteRenal CellRenal DiseaseRenal functionReporterReproductive CellsRodent ModelRoleSex CellSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSingle-Nucleus SequencingSourceSpatial DistributionSubcellular ProcessSusceptibilityT Helper FactorT-CellsT-LymphocyteT4 CellsT4 LymphocytesTC-GM-CSFTGF BTGF-betaTGF-βTGFbetaTGFβTechniquesTertiary lymphoid structureTestingTherapeuticTissue imagingTranscriptionTransforming Growth Factor betaTransforming Growth Factor-Beta Family GeneTregTumor-Cell Human GM Colony-Stimulating FactorVDCCVascular Hypertensive DiseaseVascular Hypertensive DisorderVoltage-Dependent Calcium Channelsaccessory cellacute kidney injuryantagonismantagonistattenuateattenuatesbiologicbiological signal transductioncell typecellular differentiationcellular targetingchannel blockerschronic kidney diseasecofactorcytokinedevelopmentalelevated salt consumptiongene expression patterngene expression signaturehigh blood pressurehigh salt consumptionhigh salt diethigh salt intakehigh sodium diethyperpiesiahyperpiesishypertensive diseasehypertensive disorderinitial cellinjuriesinjury responseinterferon beta 2interstitialkidney cellkidney developmentkidney disorderkidney functionkidney injuryknockout genelymph celllymphocyte activating factormouse modelmurine modelnephrogenesisneutrophilnovelpathwaypharmacologicpleiotropic effectpleiotropismpleiotropyreceptorregulatory T-cellsrenalrenal disorderrenal injuryrepairrepairedresponseresponse to injuryrestorationsNuc-Seqsexual cellsingle nucleus RNA-sequencingsingle nucleus seqsingle-nucleus RNA-seqsnRNA sequencingsnRNA-seqsocial roletertiary lymphoid organthymus derived lymphocytetissue repairtranscriptional profiletranscriptional signaturevascular
Description preview
Acute kidney injury (AKI) is a significant factor predisposing chronic kidney disease (CKD), however the factors
mediating CKD progression are not clear. T-helper 17 cells (Th17) represent a primary lymphocyte population
and may play a central role in coordinating immune and renal cell activity in AKI and subsequent CKD induced
by exposure to high…
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