grant
Long distance regressive signaling underlies sculpting of the nervous system during development.
Organization VANDERBILT UNIVERSITYLocation Nashville, UNITED STATESPosted 1 Jan 2025Deadline 31 Dec 2029
NIHUS FederalResearch GrantFY202621+ years oldAD dementiaASDAddressAdultAdult HumanAffectAllelesAllelomorphsAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimers DementiaAmyotrophic Lateral SclerosisAmyotrophic Lateral Sclerosis Motor Neuron DiseaseApoptosisApoptosis PathwayAreaAutismAutistic DisorderAxonBackBeliefBindingCategoriesCausalityCell BodyCell Communication and SignalingCell DeathCell Death InductionCell SignalingCell SurvivalCell ViabilityCell membraneCell surfaceCellsCessation of lifeCuesCytometryCytoplasmic MembraneDataDeathDependenceDevelopmentDiffuseDistalDorsumDyneinDynein ATPaseDynein Adenosine TriphosphataseDynein AdenosinetriphosphataseEarly Infantile AutismEndosomesEquilibriumEtiologyEventGP80-LNGFRGehrig's DiseaseGenerationsGoalsGrowth ConesHuntington ChoreaHuntington DiseaseHuntington'sHuntington's DiseaseHuntingtons DiseaseIn VitroInfantile AutismIntracellular Communication and SignalingKanner's SyndromeKineticsKnowledgeLengthLigandsLou Gehrig DiseaseLow-Affinity Nerve Growth Factor ReceptorMediatingMiceMice MammalsMolecularMolecular InteractionMotorMurineMusNGF ReceptorNGFR ProteinNerve CellsNerve DegenerationNerve Growth Factor ReceptorNerve Growth Factor Receptor p75Nerve UnitNervous SystemNeural CellNeurocyteNeurodevelopmental DisorderNeurologic Body SystemNeurologic Organ SystemNeurological Development DisorderNeuron DegenerationNeuronsNeurotropin Receptor p75PTK ReceptorsPalmitic Acylation SitePalmitoylation SiteParalysis AgitansParkinsonParkinson DiseasePathologicPathologyPatternPhysiologicPhysiologicalPlasma MembranePrimary ParkinsonismPrimary Senile Degenerative DementiaProcessProgrammed Cell DeathProtein CleavageProteolysisProteolytic ClippingProteolytic ProcessingReceptor ProteinReceptor Protein-Tyrosine KinasesReceptor SignalingReceptor Tyrosine Kinase GeneReceptosomesRegulationResearchRoleSchizophreniaSchizophrenic DisordersSignal PathwaySignal TransductionSignal Transduction PathwaySignal Transduction SystemsSignalingStructureSynapsesSynapticSystemTechniquesTransmembrane Receptor Protein Tyrosine KinaseTransmissionTyrosine Kinase Linked ReceptorsTyrosine Kinase ReceptorsVesicleWithdrawalWorkadulthoodautism spectral disorderautism spectrum disorderautistic spectrum disorderaxon growthaxon growth cone guidanceaxon guidanceaxonal degenerationaxonal growthbalancebalance functionbiological signal transductioncausationdegenerative axondementia praecoxdeprivationdevelopmentaldisease causationgp75 NGFRin vivoinnervationinsightnecrocytosisnerve cell deathnerve cell lossnerve supplynervous system developmentneural cell bodyneural degenerationneurodegenerationneurodegenerativeneurodevelopmental diseaseneurological degenerationneuron cell deathneuron cell lossneuron deathneuron lossneuronalneuronal cell bodyneuronal cell deathneuronal cell lossneuronal deathneuronal degenerationneuronal lossneuronal survivalneurotrophic factorneurotrophinneutrophinnovelp75p75 neurotrophin receptorp75 transcription factorp75NTRpalmitoylationplasmalemmaprimary degenerative dementiareceptorreceptor internalizationresponseretrograde transportschizophrenicsenile dementia of the Alzheimer typesocial rolesomasynapsesynapse formationsynaptogenesistraffickingtranscriptional coactivator p75transmission process
Description preview
PROJECT SUMMARY
Neurodevelopmental events occurring after axons innervate their targets can be categorized as either
progressive (e.g., cell survival, axon stabilization, promotion of synapse formation) or regressive (e.g., cell death,
axon degeneration, synapse restriction). While the molecular and cellular basis of long-distance progressive…
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