grant
Local translation and viral infection in the airway epithelium
Organization COLUMBIA UNIVERSITY HEALTH SCIENCESLocation NEW YORK, UNITED STATESPosted 9 Jun 2023Deadline 31 May 2028
NIHUS FederalResearch GrantFY20252019 novel corona virus2019 novel coronavirus2019-nCoV21+ years oldActive SitesAddressAdultAdult HumanAirAirway DiseaseAirway infectionsApicalBiological AgentBiological ProductsCOVID-19 virusCOVID19 virusCell BodyCell Communication and SignalingCell DifferentiationCell Differentiation processCell SignalingCellsCentriolesChimera ProteinChimeric ProteinsCiliaCoV-2CoV2CytoplasmCytoplasmic GranulesDataDefectDefense MechanismsEnzyme GeneEnzymesEpitheliumEventFISH TechnicFISH TechniqueFISH analysisFISH assayFluorescence In Situ HybridizationFluorescent in Situ HybridizationFusion ProteinHumanInfantInfluenza AInfluenza A virusInfluenza Viruses Type AInfluenzavirus AInhalationInhalingInitiation FactorsIntracellular Communication and SignalingKnowledgeLabelLiquid substanceLungLung DiseasesLung Respiratory SystemMammalian CellMediatingMessenger RNAMiceMice MammalsMicroRNAsModern ManMorbidityMorbidity - disease rateMorphologyMucociliary ClearanceMucociliary TransportMurineMusNamesOrthomyxovirus Type APathogenesisPathologicPathway interactionsPeptide Initiation FactorsPhenotypePlayPoly(A)+ mRNA Binding ProteinPoly(A)-Binding ProteinsProductionProtein BiosynthesisProteinsPublic HealthPulmonary Body SystemPulmonary DiseasesPulmonary DisorderPulmonary Organ SystemPuromicinaPuromycinPuromycinePuromycinumRIP seqRIPseqRNA immunoprecipitation and sequencingRNA immunoprecipitation sequencingRSV infectionReportingRespiratory EpitheliumRespiratory InfectionsRespiratory Syncytial Virus InfectionsRespiratory SystemRespiratory Tract InfectionsRespiratory TractsRespiratory physiologyRespiratory syncytial virusRespiratory tract structureRibo-seqRibonucleoproteinsRibosomal Peptide BiosynthesisRibosomal Protein BiosynthesisRibosomal Protein SynthesisRibosomal ProteinsRoleSARS corona virus 2SARS-CO-V2SARS-COVID-2SARS-CoV-2SARS-CoV2SARS-associated corona virus 2SARS-associated coronavirus 2SARS-coronavirus-2SARS-related corona virus 2SARS-related coronavirus 2SARSCoV2Severe Acute Respiratory Coronavirus 2Severe Acute Respiratory Distress Syndrome CoV 2Severe Acute Respiratory Distress Syndrome Corona Virus 2Severe Acute Respiratory Distress Syndrome Coronavirus 2Severe Acute Respiratory Syndrome CoV 2Severe Acute Respiratory Syndrome-associated coronavirus 2Severe Acute Respiratory Syndrome-related coronavirus 2Severe acute respiratory syndrome associated corona virus 2Severe acute respiratory syndrome coronavirus 2Severe acute respiratory syndrome related corona virus 2Signal TransductionSignal Transduction SystemsSignalingSiteStructure of respiratory epitheliumSystemTestingTranslatingTranslation Initiation FactorTranslational Initiation FactorTranslationsTrinucleotide RepeatsTriplet RepeatsType A InfluenzaViral DiseasesViral Gene ProductsViral Gene ProteinsViral ProteinsVirus DiseasesWuhan coronavirusadulthoodairway epitheliumbiological signal transductionbiologicsbiopharmaceuticalbiotherapeutic agentcellular differentiationciliogenesiscilium biogenesiscodon reiterationcoronavirus disease 2019 viruscoronavirus disease-19 virusdisease of the lungdisorder of the lungepithelial progenitorepithelial progenitor cellepithelial stem cellfluidglobal gene expressionglobal transcription profilegranulehCoV19liquidlong-term sequelaelung disordermRNAmRNA DegradationmRNA Transcript DegradationmiRNAmutantnCoV2namenamednamingnovelpathogenpathogenic viruspathwaypolypeptideprogramsprotein synthesispsychological defense mechanismrecruitrespiratoryrespiratory functionrespiratory tract epitheliumrespiratory virusribosome footprint profilingribosome profilingsingle moleculesocial roletranscriptometranslationviral infectionviral pathogenvirus infectionvirus pathogenvirus proteinvirus-induced disease
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Project Summary - Abstract
Multiciliated cells (MCCs) are key components of the airway epithelium playing a major role in mucociliary
clearance, the first line of lung defense against inhaled pathogens. MCCs are well-known targets of viral
pathogens, including influenza A, SARS-COVID2 and respiratory syncytial virus (RSV), often resulting in…
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