grant
Liver and kidney responses to bilirubin as a nuclear receptor hormone
Organization VANDERBILT UNIVERSITY MEDICAL CENTERLocation NASHVILLE, UNITED STATESPosted 1 Jan 2025Deadline 31 Dec 2028
NIHUS FederalResearch GrantFY202621+ years oldAddressAdultAdult HumanAgonistAntioxidantsAttenuatedBilirubinBilirubin IX alphaBindingBiologic ModelsBiological ModelsBlood SerumCPF geneCPF proteinCYP7A Promoter-Binding FactorCell BodyCell Communication and SignalingCell ProtectionCell SignalingCellsChIP SequencingChIP-seqChIPseqChemicalsChronicChronic Kidney FailureChronic Renal DiseaseChronic Renal FailureCytoprotectionDataDiabetic Kidney DiseaseDiabetic NephropathyEventFTF geneFTF proteinFatty LiverFerroprotoporphyrinGene ExpressionGene TranscriptionGenesGeneticGenetic TranscriptionGilbert DiseaseGilbert's syndromeHB1FHemeHep G2HepG2HepG2 cell lineHepatic CellsHepatic Parenchymal CellHepatocyteHumanHuman B1-Binding FactorIcterusIntracellular Communication and SignalingJaundiceKidneyKidney DiseasesKidney Urinary SystemKnock-outKnockoutLRH1LigandsLipidsLiverLiver CellsLiver Receptor Homolog 1Liver SteatosisMediatingMiceMice MammalsModel SystemModelingModern ManMolecularMolecular InteractionMurineMusNR5A2NR5A2 geneNephropathyNormal RangeNormal ValuesNuclear Hormone Receptor SuperfamilyNuclear Hormone ReceptorsNuclear Receptor Subfamily 5, Group A, Member 2Nuclear ReceptorsOrganoidsPPAR alphaPPAR-αPPARalphaPPARαPatientsPeroxisome Proliferator-Activated Receptor alphaPeroxisome Proliferator-Activated Receptor αPhosphatidesPhospholipidsPositionPositioning AttributeProcessPropertyProteinsProteomicsProtohemeRNA ExpressionReceptor ProteinRenal CellRenal DiseaseRenal functionRoleSerumShort interfering RNASignal TransductionSignal Transduction SystemsSignalingSiteSmall Interfering RNASpecificityStructureTestingTranscriptTranscriptionVisceral Epithelial Celladulthoodattenuateattenuatesbiological signal transductionchromatin immunoprecipitation coupled with sequencingchromatin immunoprecipitation followed by sequencingchromatin immunoprecipitation with sequencingchromatin immunoprecipitation-seqchromatin immunoprecipitation-sequencingchronic kidney diseasecongenital nonhemolytic jaundicecytoprotectivediabeticdiabetic patientefflux pumpferrohemefetoprotein transcription factorgene manipulationgenetic manipulationgenetically manipulategenetically perturbglobal gene expressionglobal transcription profileglomerular visceral epithelial cellhepatic body systemhepatic organ systemhepatic steatosishepatosteatosishereditary nonhemolytic jaundicehuman modelintrahepatickidney cellkidney disorderkidney functionliver functionmodel of humannew approachesnovel approachesnovel strategiesnovel strategypodocytepreventpreventingpromoterpromotorprotective effectreceptorrenalrenal disorderresponsesensorsiRNAsmall moleculesocial roletranscriptome
Description preview
Summary: The heme metabolite unconjugated bilirubin is toxic at high levels, but also has beneficial effects
when slightly elevated within the normal range as seen in Gilbert’s syndrome, with benefits including protection
from diabetic kidney disease and chronic kidney disease. These benefits had been attributed exclusively to the
antioxidant…
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