grant
Lipidomics Shared Resource Core
Organization STATE UNIVERSITY NEW YORK STONY BROOKLocation STONY BROOK, UNITED STATESPosted 1 Aug 2003Deadline 31 Aug 2030
NIHUS FederalResearch GrantFY2025Advanced DevelopmentAssayBioassayBiochemistryBiocompatible MaterialsBioinformaticsBiologicalBiological AssayBiological ChemistryBiological FunctionBiological ProcessBiologyBiomaterialsBloodBlood PlasmaBlood Reticuloendothelial SystemBlood SerumBody TissuesCalibrationCancer BiologyCancer TreatmentCancersCell BodyCell Communication and SignalingCell SignalingCell membraneCell modelCellsCellular modelCeramidesChemistryCholineComplexCulture MediaCultured CellsCytoplasmic MembraneD-GalactoseD-GlucoseDataData AnalysesData AnalysisData BasesData SetDatabasesDevelopmentDextroseEducational workshopEnsureEnzyme GeneEnzymesEvaluation MethodologyExperimental DesignsFamilyFundingGalactopyranoseGalactopyranosideGalactoseGlucoseGoalsHPLCHigh Performance Liquid ChromatographyHigh Pressure Liquid ChromatographyHigh Speed Liquid ChromatographyHistoryHomeHumanHuman ResourcesHydroxylationImageIn SituIn VitroIndividualIntermediary MetabolismInternationalIntracellular Communication and SignalingIntratumoral heterogeneityInvestigatorsLeadLengthLipid ChemistryLipidsLiquid substanceMALD-MSMALDIMALDI-MSMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant TumorManpowerManuscriptsMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMeasurementMeasuresMembraneMentorsMetabolicMetabolic ProcessesMetabolismMethodologyMethodsMiceMice MammalsModern ManModificationMolecular AnalysisMonitorMurineMusNational Institutes of HealthPathologicPathway interactionsPatternPb elementPhosphatesPhysiologic pulsePlasmaPlasma MembranePlasma SerumPostdocPostdoctoral FellowProceduresProteomicsProtocolProtocols documentationPublishingPulseRNA SeqRNA sequencingRNAseqRecording of previous eventsRegulationResearch AssociateResearch PersonnelResearch ResourcesResearchersResource SharingResourcesReticuloendothelial System, Serum, PlasmaSerumServicesSignal TransductionSignal Transduction SystemsSignalingSpectrometrySpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationSpectroscopy, Mass, Matrix-Assisted Laser Desorption-IonizationSphingolipidsSphingomyelinsSpinal ColumnSpineStudentsTechnologyTissue SampleTissuesTrainingTumor TissueUnited States National Institutes of HealthVariantVariationVertebral columnWorkWorkshopanaloganalytical toolanti-cancer therapybackbonebiochemical toolsbiochemistry toolsbiologicbiological materialbiological signal transductioncancer therapycancer-directed therapydata basedata interpretationdata sharingdesigndesigningdetection methoddetection proceduredetection techniquedevelopmentalenzyme activityexperimentexperimental researchexperimental studyexperimentsfat metabolismflexibilityflexiblefluidgrowth mediaheavy metal Pbheavy metal leadheterogeneity in tumorshistorieshomesimagingimaging spectroscopyin vivoinhibitorinorganic phosphateintra-tumoral heterogeneityintratumor heterogeneitylipid mediatorlipid metabolismlipidomicsliquidmalignancymatrix assisted laser desorption ionizationmembermembrane structuremethod developmentneoplasm/cancernovelpathwaypersonnelplasmalemmapost-docpost-doctoralpost-doctoral traineeprogramsresearch associatesresponsespectroscopic imagingspheroidsstructural mutationstructural variantstructural variationsuccesssugartandem mass spectrometrytooltranscriptome sequencingtranscriptomic sequencingtranslational modeltumor heterogeneity
Description preview
ABSTRACT
Dysfunctional metabolism of bioactive lipids, including sphingolipids (SLs), contributes to the pathobiology of
cancer development and progression, the study of which is the main goal for the three experimental projects in
this PPG. The appreciation for the depth of complexity involved in SL metabolism and signaling has recently
expanded…
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