grant
Lipid Imaging in Traumatic Brain Injury by High Resolution GCIB-secondary Ion Mass Spectrometry
Organization COLUMBIA UNIVERSITY HEALTH SCIENCESLocation NEW YORK, UNITED STATESPosted 1 Jul 2012Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY202515-LOX15-Lipoxygenase3-D Imaging3D imagingAcid-Thiol LigasesAcquired brain injuryAcyl CoA SynthetasesAcyl Coenzyme A SynthetasesAddressAgeAmidesAnabolismAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryArachidonate 15-LipoxygenaseArachidonate Omega-6 LipoxygenaseArachidonic Acid 15-LipoxygenaseArachidonic AcidsAreaAutomobile DrivingBinding ProteinsBiologyBody TissuesBrainBrain InjuriesBrain Nervous SystemBrain TraumaCause of DeathCell BodyCell Communication and SignalingCell DeathCell SignalingCellsCephalinsCessation of lifeClinicalCo A LigasesCoenzyme A LigasesCoenzyme A SynthetasesComplexDataDeathElevated Intracranial PressureEmploymentEncephalonEndocannabinoidsEndogenous CannabinoidsEthanolamine PhosphoglyceridesEthanolamineglycerophospholipidsEvaluationFamily memberGasesGenerationsGoalsHydrogen OxideImageImaging ProceduresImaging TechnicsImaging TechniquesImaging technologyIndividualInflammationInflammatory ResponseInjuryIntracellular Communication and SignalingIntracranial HypertensionIntracranial Pressure ElevationIntracranial Pressure IncreaseIonsLabelLanthanidesLanthanoid Series ElementsLanthanoidsLateralLigand Binding ProteinLigand Binding Protein GeneLipid PeroxidationLipidsLiquid ChromatographyMapsMechanicsMethodsMiceMice MammalsMinorModelingMolecularMurineMusN arachidonoyl 2 hydroxyethylamideN-arachidonoylethanolamineNecrosisNecroticO-(1-beta-acyl-2-acyl-sn-glycero-3-phospho)-ethanolamineOxidation-ReductionPathogenesisPathway interactionsPatients with traumatic brain injuryPhosphatidesPhosphatidylethanolaminePhospholipidsPositionPositioning AttributeProcessProtein BindingProteinsProtocolProtocols documentationReactionRedoxRefractoryRegulationResolutionReticulocyte Arachidonate 15-LipoxygenaseRoleSIMS MicroscopyScaffolding ProteinSecondary Ion Mass Spectrometry MicroscopySecondary Ion Mass Spectroscopy MicroscopySecondary toSeriesSignal TransductionSignal Transduction SystemsSignalingSpecificitySpectrometry, Mass, Secondary IonSpectroscopy, Mass, Secondary IonTBI PatientsTechnologyTestingThree-Dimensional ImagingTimeTissuesTraumatic Brain InjuryWateracyl groupadult youthagesamino groupanandamideantibody conjugatearachidonoyl ethanolamidearachidonoylethanolamidearachidonylethanolamideassess effectivenessbiological signal transductionbiosynthesisbound proteinbrain damagebrain tissuebrain-injuredcatalystcell typecontrolled cortical impactdesigndesigningdetermine effectivenessdisabilitydrivingeffectiveness assessmenteffectiveness evaluationevaluate effectivenessexamine effectivenesshigh resolution imagingimagingimaging mass spectrometryinhibitorinjuriesinnovateinnovationinnovativelipidomicsmass spectrometric imagingmechanicmechanicalmetermultiomicsmultiple omicsnecrocytosisneuropathologicneuropathologicalneuropathologynoveloxidationoxidation reduction reactionpanomicspathwayperoxidationprogramsprotein complexraised ICPraised intracranial pressureresolutionssmall moleculesocial roletargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmentthiokinasetransacylationtraumatic brain damagetraumatic brain injury patientsyoung adultyoung adult ageyoung adulthood
Description preview
Traumatic brain injury (TBI) is a major cause of death and disability across all ages. Secondary injury
mechanisms of phospholipid (PL) peroxidation and cell death are implied in the expansion of the damage
caused by the primary insult. We discovered that a required step in necrotic cell death, ferroptosis, triggered
by TBI is peroxidation of…
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