grant
Lipid imaging expansion microscopy to study Alzheimer's disease
Organization MASSACHUSETTS INSTITUTE OF TECHNOLOGYLocation CAMBRIDGE, UNITED STATESPosted 1 May 2024Deadline 31 Jan 2029
NIHUS FederalResearch GrantFY2026AD brainAD dementiaAD modelAD pathologyAD pathwayAD patientsAD riskAD risk factorAD-associated pathwaysAD-related pathwaysAD-specific pathwaysAPOEAPOE e4APOE-ε4APOEε4APP processingAffectAllelesAllelomorphsAlzheimer Type DementiaAlzheimer beta-ProteinAlzheimer disease dementiaAlzheimer disease mechanismAlzheimer pathwayAlzheimer risk factorAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's Amyloid beta-ProteinAlzheimer's DiseaseAlzheimer's Disease PathwayAlzheimer's amyloidAlzheimer's brainAlzheimer's disease brainAlzheimer's disease modelAlzheimer's disease pathologyAlzheimer's disease patientAlzheimer's disease riskAlzheimer's mechanismAlzheimer's pathologyAlzheimer's patientAlzheimer's related pathwaysAlzheimers DementiaAmyloid (Aβ) plaquesAmyloid Alzheimer's Dementia Amyloid ProteinAmyloid Beta-PeptideAmyloid PlaquesAmyloid Protein A4Amyloid beta-ProteinAmyloid βAmyloid β-PeptideAmyloid β-ProteinAnimal ModelAnimal Models and Related StudiesAntibodiesApo-EApoE proteinApolipoprotein EArchitectureAstrocytesAstrocytusAstrogliaAtlasesAutopsyAβBiologicalBiologyBody TissuesBrain PathologyCausalityCell Communication and SignalingCell Membrane Lipid RaftsCell Membrane LipidsCell SignalingCell membraneCessation of lifeCharacteristicsChemicalsCholesterolCodeCoding SystemCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalCytoplasmic MembraneDataDeathDegenerative Neurologic DisordersDemocracyDepositDepositionDevelopmentDiseaseDisorderDisturbance in cognitionER stressElectron MicroscopyEndoplasmic ReticulumEndosomesEngineering / ArchitectureEquipmentErgastoplasmEtiologyFutureGenesGenetic predisposing factorGliaGlial CellsGolgiGolgi ApparatusGolgi ComplexGrantHeadHortega cellHumanImageImpaired cognitionImpairmentInflammationIntracellular Communication and SignalingIntracellular StructureInvestigatorsKolliker's reticulumLate Onset Alzheimer DiseaseLate onset ADLipid TraffickingLipidsLysosomesMediatingMembraneMembrane LipidsMembrane MicrodomainsMethodsMiceMice MammalsMicrogliaMicroscopeMicroscopyMitochondriaModelingModern ManMolecularMorphologyMurineMusMyelinNerve CellsNerve UnitNervous System Degenerative DiseasesNeural CellNeural Degenerative DiseasesNeural degenerative DisordersNeuritic PlaquesNeurocyteNeurodegenerative DiseasesNeurodegenerative DisordersNeurogliaNeuroglial CellsNeurologic Degenerative ConditionsNeuronsNoiseNon-neuronal cellNonneuronal cellOligodendrocytesOligodendrocytusOligodendrogliaOligodendroglia CellOrganellesPathologyPlasma MembranePlayPrimary Senile Degenerative DementiaProceduresProductionPropertyProteinsProtocolProtocols documentationPublicationsReceptosomesReportingResearchResearch PersonnelResearch SpecimenResearchersResolutionResource SharingRisk-associated variantRoleScienceScientific PublicationSenile PlaquesSignal TransductionSignal Transduction SystemsSignalingSiteSpecimenSphingolipid MicrodomainsSphingolipid-Cholesterol RaftsStaining methodStainsSubcellular structureSynapsesSynapticTau forming aggregatesTechnologyTemperatureTissuesValidationVisualizationa beta peptideabetaabnormally aggregated tau proteinaggregation in taualzheimer modelalzheimer riskamyloid betaamyloid beta plaqueamyloid precursor protein processingamyloid-b plaqueamyloid-b proteinanalytical toolapo E-4apo E4apo epsilon4apoE epsilon 4apoE-4apoE4apolipoprotein E epsilon 4apolipoprotein E-4apolipoprotein E4astrocytic gliaaβ plaquesbeta amyloid fibrilbiologicbiological signal transductionbrain cellbrain circuitrybrain tissuecausationcell typecognitive dysfunctioncognitive losscored plaquedegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdevelopmentaldiffuse plaquedisease causationendoplasmic reticulum stressextracellularfilamentous tau inclusiongenetic risk factorgitter cellhuman tissuehyper-phosphorylated tauhyperphosphorylated tauimaginginherited factorinventionlate endosomelate onset alzheimerlipid raftlipid transportmechanisms in ADmechanisms in Alzheimer's diseasemembrane structuremesogliamicroglial cellmicrogliocytemicrotubule associated protein tau aggregationmicrotubule associated protein tau depositmitochondrialmodel of animalmouse modelmurine modelmyelinationnano meter scalenano meter sizednanometer scalenanometer sizednanoscalenecropsynerve cell deathnerve cell lossnerve cementneurodegenerative illnessneuron cell deathneuron cell lossneuron deathneuron lossneuronalneuronal cell deathneuronal cell lossneuronal deathneuronal lossnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetoptogeneticspaired helical filament of taupathways associated with ADpathways associated with Alzheimer'spathways contribute to Alzheimer'spathways involved in Alzheimer diseasepathways that contribute to ADpathways that drive ADpathways underlying Alzheimer'spatient living with Alzheimer's diseasepatient suffering from Alzheimer's diseasepatient with Alzheimer'spatient with Alzheimer's diseasepatients with ADperivascular glial cellplasmalemmapostmortempreservationprimary degenerative dementiaresolutionsrisk allelerisk factor for developing Alzheimer'srisk factor in Alzheimer'srisk generisk genotyperisk locirisk locusrisk of developing Alzheimer'srisk variantself-aggregate tausenile dementia of the Alzheimer typeskillssocial rolesoluble amyloid precursor proteinsuccesssynapsetau PHFtau accumulationtau aggregatetau aggregationtau fibrillationtau fibrillizationtau filamenttau inclusiontau neurofibrillary tangletau oligomertau paired helical filamenttau polymerizationtau protein accumulationtau protein aggregationtau-tau interactiontoolvalidationsτ aggregation
Description preview
Alzheimer's disease (AD) is a fatal neurodegenerative disease characterized by progressive cognitive decline
and brain pathologies including amyloid-β (Aβ) peptide deposition, hyperphosphorylated tau accumulation,
inflammation, and synaptic and neuronal loss. In addition to protein pathology, the abnormal accumulation of
lipids in AD brains –…
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