grant
Linking the molecular operations of cohesin to its physiological activity in the mammalian brain
Organization UNIVERSITY OF CALIFORNIA, SAN FRANCISCOLocation SAN FRANCISCO, UNITED STATESPosted 1 Sept 2024Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY2025ArchitectureBar CodesBehaviorBiologic ModelsBiological ModelsBrainBrain Nervous SystemCNS Nervous SystemCell BodyCell FunctionCell PhysiologyCell ProcessCell Surface ProteinsCell surfaceCellsCellular FunctionCellular PhysiologyCellular ProcessCentral Nervous SystemChromatinChromatin LoopChromatin Loop DomainsChromosomal OrganizationChromosomal StructureChromosome OrganizationChromosome StructuresCognitive DiscriminationComplexCoupledCouplingDNADNA LoopDataDeoxyribonucleic AcidDevelopmentDevelopmental ProcessDiscriminationDiseaseDisorderEncephalonEngineering / ArchitectureEnhancersEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessGene Action RegulationGene ArrangementGene ClusterGene ExpressionGene Expression RegulationGene OrderGene PositionGene RegulationGene Regulation ProcessGenerationsGenesGenomeHealthHumanIndividualIntegral Membrane ProteinIntrinsic Membrane ProteinLinkMammalian CellMediatingMiceMice MammalsModel SystemModelingModern ManMolecularMurineMusNerve CellsNerve UnitNeural CellNeural DevelopmentNeuraxisNeurocyteNeuronsNuclearOlfactory EpitheliumOlfactory PathwaysOlfactory systemPatternPhysiologicPhysiologicalPlayProcessProteinsRegulationRegulatory ElementResearch ProposalsRestRoleShapesSisterStructureSubcellular ProcessSystemTestingTransmembrane ProteinTransmembrane Protein GeneVariantVariationbarcodecell typecohesincohesioncombinatorialdemethylationdevelopmentalepigeneticallygain of functiongene locusgenetic locusgenomic locationgenomic locusin vivoinsightloss of functionmammalian genomeneuralneural circuitneural circuitryneurocircuitryneurodevelopmentneuron developmentneuronalneuronal developmentnovelolfactory circuitryolfactory circuitsolfactory sensory neuronsoperationoperationspostmitoticprogenitor cell poolprogenitor cell populationprogenitor poolprogenitor populationpromoterpromotorprotein complexprotein functionraphe nucleisocial rolestem and progenitor cell populationstem cell poolstem cell populationsynaptic circuitsynaptic circuitry
Description preview
PROJECT SUMMARY
Mammalian genomes are organized into loops and topologically associated domains by the cohesin protein
complex. The formation of these structures has suggested models for how DNA regulatory elements, such as
enhancers and promoters, are spatially arranged to coordinate gene expression. However, testing these models
and their…
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