grant
Linking metabolic activity with drug sensitivity using metabolic influence networks
Organization UNIVERSITY OF MICHIGAN AT ANN ARBORLocation ANN ARBOR, UNITED STATESPosted 1 Aug 2020Deadline 31 May 2030
NIHUS FederalResearch GrantFY2025AddressAffectBehaviorBiological MarkersCell BodyCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCellsCellular FunctionCellular Metabolic ProcessCellular PhysiologyCellular ProcessComputer ModelsComputerized ModelsDNA MethylationData SetDietDiseaseDisorderDrug CombinationsDrug ToleranceDrugsE coliE. coliEnvironmentEnzyme AntagonistEnzyme GeneEnzyme InhibitorEnzyme Inhibitor AgentEnzyme Inhibitor DrugsEnzymesEscherichia coliFunctional RNAGene Action RegulationGene Expression RegulationGene RegulationGene Regulation ProcessHeterogeneityHuman Cell LineImageIn VitroIndividualIntermediary MetabolismIntracellular Communication and SignalingLinkMachine LearningMedicationMetabolicMetabolic ProcessesMetabolismMethodsModelingMultiomic DataNoncoding RNANontranslated RNANutrientPharmaceutical PreparationsPhasePhenotypeRNA SplicingRegulationResearchSignal TransductionSignal Transduction SystemsSignalingSplicingSubcellular ProcessSystemSystems BiologyTestingUntranslated RNAYeastsbio-markersbiologic markerbiological signal transductionbiomarkercell engineeringcell metabolismcellular engineeringcellular metabaolismcomputational modelingcomputational modelscomputer based modelscomputerized modelingdietsdrug actiondrug discoverydrug efficacydrug sensitivitydrug/agentgenome scalegenome-widegenomewidehuman modelimagingin vivoinnovateinnovationinnovativemachine based learningmodel of humanmodel organismmultiple omic datanetwork modelsnew technologynoncodingnovel technologiesprecision medicineprecision-based medicineprogramsresponsesingle cell analysisspatial and temporalspatial multiomicsspatial omicsspatial temporalspatial tri-omicsspatiotemporalsynthetic biologyuptake
Description preview
My lab develops systems biology models of metabolic regulation and applies these for drug discovery. The impact of cellular metabolism on drug response has been observed in a wide range of diseases. However, how metabolism influences the activity of diverse classes of drugs has not been systematically explored. This has been a challenge due to the…
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