grant
Linking disruptions in state representation processes to neural signal impairment in nonhuman primates
Organization UNIVERSITY OF MINNESOTALocation MINNEAPOLIS, UNITED STATESPosted 1 Apr 2020Deadline 30 Apr 2030
NIHUS FederalResearch GrantFY202512-20 years oldAction PotentialsAdolescenceAnatomic SitesAnatomic structuresAnatomyAreaBackBehavioralBiologic ModelsBiologicalBiological ModelsBiologyBrainBrain Nervous SystemCNS plasticityCell BodyCell Communication and SignalingCell SignalingCellsComputer ModelsComputerized ModelsCorpus StriatumCorpus striatum structureDataDecision MakingDendritic SpinesDiffusionDopamineDopamine ReceptorDorsalDorsumEncephalonExperimental DesignsFoundationsFundingGangliaGoalsHumanHydroxytyramineImpairmentIndividualIntracellular Communication and SignalingKnowledgeLeadLearningLinkMacacaMacaqueMaintenanceMeasuresMediatingModel SystemModelingModern ManMolecularMonkeysN Methyl D aspartic AcidN methyl D aspartateN-Methyl-D-Aspartate ReceptorsN-Methyl-D-aspartateN-MethylaspartateN-Methylaspartate ReceptorsNMDANMDA Receptor-Ionophore ComplexNMDA ReceptorsNerve CellsNerve Impulse TransmissionNerve TransmissionNerve UnitNeural CellNeural GanglionNeurocyteNeuronal PlasticityNeuronal TransmissionNeuronsNeurophysiology - biologic functionOutputPathogenicityPathogenicity FactorsPatternPb elementPersonsPhysiologicPhysiologicalPlayPopulationPrefrontal CortexProcessPsychological reinforcementPsychosesReceptor SignalingReinforcementRewardsRoleSignal TransductionSignal Transduction SystemsSignalingStriate BodyStriatumSymptomsSynapsesSynapticSynaptic plasticityTask PerformancesTestingTrainingVariantVariationVirulence Factorsabnormal brain functionadolescence (12-20)analytical methodaxon signalingaxon-glial signalingaxonal signalingbiologicbiological signal transductionbrain dysfunctionbrain impairmentcentral nervous system plasticitycognitive controlcognitive trainingcomputational modelingcomputational modelscomputer based modelscomputerized modelingdendrite spinediffuseddiffusesdiffusingdiffusionsdysfunctional brainearly psychosisexperimentexperimental researchexperimental studyexperimentsfMRI/EEGfirst episode psychosisfunctional magnetic resonance imaging/electroencephalographyfunctional restorationglia signalingglial signalingheavy metal Pbheavy metal leadinsightnerve signalingneuralneural correlateneural functionneural plasticityneural signalingneuronalneuronal signalingneurophysiologicalneurophysiologyneuroplasticneuroplasticityneurotransmissionnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeutic targetnew therapy approachesnew therapy targetnew treatment approachnew treatment strategynon-human primatenonhuman primatenovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeutic targetnovel therapy approachnovel therapy targetoperationoperationspersonalization of treatmentpersonalized medicinepersonalized therapypersonalized treatmentpharmacologicpostsynapticpresynapticreceptor-mediated signalingrestore functionrestore functionalityrestore lost functionsocial rolestriatalsynapsesynapse failuresynapse functionsynaptic failuresynaptic function
Description preview
PROJECT 3 - PROJECT SUMMARY
PROJECT 3 will identify and characterize neurophysiological signals at cellular and network scales in
nonhuman primates that carry out computations for state representation processes of state estimation, state
maintenance, and state learning. We will induce a temporary state of brain dysfunction in macaques that is…
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