grant
Linking brain micro- and meso-structure with cognitive functioning
Organization NATIONAL INSTITUTE ON AGINGLocation UNITED STATES
NIHUS FederalResearch GrantFY202521+ years oldAD dementiaAddressAdultAdult HumanAgeAgingAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimers DementiaAmentiaAmyloidAmyloid SubstanceArchitectureAstrocytesAstrocytusAstrogliaAtrophicAtrophyAxonBaltimoreBehavioralBiologicalBiological MarkersBloodBlood Reticuloendothelial SystemBody TissuesBrainBrain Nervous SystemBrain imagingBrain regionCell Communication and SignalingCell FunctionCell Membrane PermeabilityCell PhysiologyCell ProcessCell SignalingCell membraneCellular FunctionCellular MorphologyCellular PhysiologyCellular ProcessCerebrumCharacteristicsChemicalsClinicalCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalComplexCoupledCytoplasmic MembraneDWI (diffusion weighted imaging)DWI-MRIDataDementiaDendritic SpinesDevelopmentDiffusionDiffusion MRIDiffusion Magnetic Resonance ImagingDiffusion Weighted MRIDiffusion weighted imagingDiffusion-weighted Magnetic Resonance ImagingDimensionsDiseaseDisorderDisturbance in cognitionEncephalonEngineering / ArchitectureEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessFemaleFiberFrequenciesGelGeneticGoalsHeterogeneityHistologicHistologicallyHumanImageImpaired cognitionIntracellular Communication and SignalingInvestigationLaboratoriesLinkLongitudinal StudiesMR ImagingMR TomographyMRIMRI biomarkerMRI markerMRIsMagnetic Resonance ImagingMeasuresMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMethodsMicroscopicModern ManMorphologyMyelinNMR ImagingNMR TomographyNerve CellsNerve UnitNeural CellNeuritesNeurocognitiveNeurocyteNeuronsNuclear Magnetic Resonance ImagingOutcomeParticipantPerformancePhenotypePlasma MembranePlayPowder dose formPowdersPrimary Senile Degenerative DementiaPropertyProtocolProtocols documentationRelaxationReproducibilityResolutionRoleScanningShapesSignal TransductionSignal Transduction SystemsSignalingStructureSubcellular ProcessSynapsesSynapticTestingThickThicknessTimeTissuesWorkZeugmatographyaberrant agingabnormal agingadulthoodage associatedage associated differenceage associated functional declineage based differenceage correlatedage dependentage dependent differenceage dependent functional declineage dependent variationage differenceage induced loss of functionage linkedage relatedage related differenceage related functional declineage related variationage specificage specific differenceage-related loss of functionaged brainagesaging associated functional declineaging brainaging induced functional declineaging related functional declineastrocytic gliabehavior testbehavioral testbio-markersbiologicbiologic markerbiological signal transductionbiomarkerbrain tissuebrain visualizationcell morphologycerebralcognitive assessmentcognitive dysfunctioncognitive functioncognitive losscognitive testingcohortconnectomedMRIdata acquisitiondata acquisitionsdendrite spinedensitydesigndesigningdevelopmentaldiffer by agedifference across agedifference in agediffuseddiffusesdiffusingdiffusion tensor imagingdiffusionsdysfunctional age related changedysfunctional agingepigeneticallyextracellularfunctional decline due to agingfunctional decline with agefunctional decline with agingfunctional loss with aginggray matterhealthy aginghealthy human aginghealthy volunteerhuman subjectimagingimpaired aginginsightlife spanlifespanlong-term studylongitudinal outcome studiesmagnetic resonance imaging biomarkermagnetic resonance imaging markermaladaptive agingmembrane permeabilitymild cognitive disordermild cognitive impairmentmillimeternatural agingneural imagingneural inflammationneuro-imagingneurobehavioralneurofilamentneuroimagingneuroinflammationneuroinflammatoryneurological imagingneuronalnormal agingnormative agingnovelold agepathological age related changespathological agingplasmalemmapre-clinicalpreclinicalprimary degenerative dementiaprotocol developmentquantification of agingresolutionssenile dementia of the Alzheimer typesocial rolesubstantia albasubstantia griseasynapsevariation by agewhite matter♀
Description preview
In this project we combine pre-clinical and clinical MRI sequences that allows the simultaneous T1, T2, and diffusion encoding (i.e., diffusion-relaxation multidimensional MRI) with complementary histological methods, cognitive assessment, and blood biomarkers, to investigate cellular processes that relate to function, microstructure, and chemical…
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