grant
Levothyroxine Dosing in Older Individuals
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 15 May 2023Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY202521+ years old65 and older65 or older65 years of age and older65 years of age or more65 years of age or older65+ years65+ years oldAdultAdult HumanAgeAged 65 and OverAtrial FibrillationAuricular FibrillationBP controlBP managementC-telopeptideCardiovascularCardiovascular Body SystemCardiovascular Organ SystemCardiovascular systemClinicalClinical TreatmentClinical TrialsCognitiveConfidence IntervalsDataDiabetes MellitusDiseaseDisorderDoseDouble-Blind MethodDouble-Blind StudyDouble-BlindedDouble-Masked MethodDouble-Masked StudyDrug PrescribingDrug PrescriptionsDysfunctionFrequenciesFunctional disorderGoalsGuidelinesHealthHealth ExpendituresHealth Insurance for Aged and Disabled, Title 18Health Insurance for Disabled Title 18Health StatusHeart VascularHip FracturesHypertensionHypoglycemiaHypotensionHypothyroidismIndividualL-ThyroxineLDL CholesterolLDL Cholesterol LipoproteinsLaboratoriesLeftLevel of HealthLevothyroxineLipidsLow Blood PressureLow Density Lipoprotein CholesterolMeasuresMedicareMemoryMonitorMoodsMusculoskeletalObservation researchObservation studyObservational StudyObservational researchOlder PopulationOutcomePatient Outcomes AssessmentsPatient Reported MeasuresPatient Reported OutcomesPatientsPersonsPhysiologicPhysiologicalPhysiopathologyPopulationPopulation DistributionsQOLQuality of lifeQuestionnairesRandomizedRecombinant TSHRecombinant Thyroid-Stimulating HormoneReference RangesReference ValuesRiskRisk ReductionRisk-Benefit AssessmentSleepSymptomsT4 Thyroid HormoneTestingTherapeutic IndexTherapeutic LevothyroxineThyreotropinThyroidThyroid DiseasesThyroid Function TestsThyroid GlandThyroid Gland DiseaseThyroid Gland DisorderThyroid Gland Function TestsThyroid Gland HormoneThyroid Head and NeckThyroid HormonesThyroid Stimulating HormoneThyroid-Stimulating HormoneThyrotropinThyroxineTitle 18TitrationsVascular Hypertensive DiseaseVascular Hypertensive DisorderVascular Hypotensive DisorderWeightabove age 65adulthoodafter age 65age 65 and greaterage 65 and olderage 65 or olderageage of 65 years onwardaged 65 and greateraged 65+aged ≥65agesbeta-Lipoprotein Cholesterolblood pressure controlblood pressure managementbone turnovercirculatory systemclinical interventionclinical practiceclinical relevanceclinical therapyclinically relevantcognitive assessmentcognitive functioncognitive testingcostdiabetesevidence baseexecutive controlexecutive functionflexibilityflexibleglycemic controlhealth care expenditurehealth insurance for disabledhealth levelhigh blood pressurehuman old age (65+)hyperpiesiahyperpiesishypertensive diseasehypertensive disorderhypoglycemichypoglycemic episodesmedical expendituremedication prescriptionolder adultolder adulthoodolder groupsolder individualsolder personover 65 yearsover-treatmentovertreatmentpathophysiologypeerpharmacologicprescribed medicationprimary outcomerandomisationrandomizationrandomized placebo-controlled clinical trialrandomly assignedreduce riskreduce risksreduce that riskreduce the riskreduce these risksreduces riskreduces the riskreducing riskreducing the riskrisk-reducingsecondary outcomethyroid disorderthyroid functionthyroxintrial regimentrial treatmentweights≥65 years
Description preview
PROJECT SUMMARY
Approximately 10% of US adults aged 65 years or older take levothyroxine to treat hypothyroidism. Guidance
for its management has vast and important implications for the health and health care expenditures of millions
of older people. Levothyroxine has a narrow therapeutic index that requires monitoring of dosing through
thyroid…
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