grant
Leveraging ubiquitin-dependent regulatory mechanisms to improve proteome quality in health and disease
Organization UNIVERSITY OF CALIFORNIA, SAN DIEGOLocation LA JOLLA, UNITED STATESPosted 1 Mar 2023Deadline 29 Feb 2028
NIHUS FederalResearch GrantFY2026APF-1ATP-Dependent Proteolysis Factor 1Aberrant ChromosomeAbscissionAge related pathologiesBiochemicalBiogenesisCell BodyCell Growth in NumberCell LineCell MultiplicationCell ProliferationCellLineCellsCellular ProliferationCellular StressCellular Stress ResponseChromosomal AberrationsChromosomal AbnormalitiesChromosomal AlterationsChromosome AberrationsChromosome AlterationsChromosome AnomaliesChromosome abnormalityChronicComplexCytogenetic AberrationsCytogenetic AbnormalitiesDNA ReplicationDNA SynthesisDNA biosynthesisDNA mutationDefectDegenerative Neurologic DisordersDetectionDevelopmentDiseaseDisorderDissectionExcisionExtirpationGene TranscriptionGenetic ChangeGenetic TranscriptionGenetic defectGenetic mutationGoalsHMG-20HealthHigh Mobility Protein 20HumanHuman PathologyLengthLength of LifeLigaseLigase GeneLinkLongevityMessenger RNAModern ManMolecularMutationNatureNervous System Degenerative DiseasesNervous System DiseasesNervous System DisorderNeural Degenerative DiseasesNeural degenerative DisordersNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNeurologic DisordersNeurologic DysfunctionsNeurological DisordersOrigin of LifeOutcomes ResearchPathway interactionsPersonsPrevalenceProcessProductionProliferatingProteinsProteomeQuality ControlRNA ExpressionRecyclingRemovalResearchRibosomesStrains Cell LinesStressStructureSurgical RemovalSynthetasesSystemToxic effectToxicitiesTranscriptionTranslation InitiationTranslationsTriageTumor CellUbiquitinUbiquitin Ligase Component GeneUbiquitin Ligase GeneVariantVariationabnormal protein homeostasisabnormal proteostasisage associated pathologiesage dependent pathologiesage induced pathologiesaging associatedaging associated diseaseaging associated disordersaging associated pathologiesaging dependent pathologiesaging induced pathologiesaging pathologiesaging relatedaging related diseaseaging related disordersaging related pathologiescell stresschromosomal defectchromosome defectcombatcultured cell linedefective proteostasisdegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdevelopmentaldisease associated with agingdisease of agingdisorder of agingdisorders associated with agingdisorders related to agingfitnessgenome editinggenome mutationgenomic editinghealthspanhealthy life spanimprovedmRNAneoplastic cellneurodegenerative illnessneurological diseaseneurological dysfunctionpathwayprotein homeostasisprotein homeostasis declineprotein homeostasis deficiencyprotein homeostasis dysfunctionprotein homeostasis failureprotein homeostasis lossproteostasisproteostasis declineproteostasis defectproteostasis deficiencyproteostasis dysfunctionproteostasis dysregulationproteostasis failureproteostasis impairmentproteostasis lossproteotoxicproteotoxicityresectionresponsetranslationubiquitin ligase
Description preview
PROJECT SUMMARY
Errors associated with DNA replication, transcription, mRNA processing, and protein biogenesis result in the
continuous production of potentially toxic defective proteins. The error-prone nature of these essential processes
requires robust quality control (QC) systems to effectively triage and destroy defective translation…
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