grant
Leveraging Sex Differences to Understand the Brain Macrophage Response to Perinatal Hypoxia-Ischemia
Organization UNIVERSITY OF COLORADO DENVERLocation Aurora, UNITED STATESPosted 5 Aug 2025Deadline 30 Jun 2030
NIHUS FederalResearch GrantFY20250-11 years oldAblationAcquired brain injuryAddressApoplexyAstrocytesAstrocytusAstrogliaBiologyBloodBlood - brain barrier anatomyBlood Reticuloendothelial SystemBlood monocyteBlood-Brain BarrierBrainBrain Hypoxia-IschemiaBrain InjuriesBrain Nervous SystemBrain Vascular AccidentCause of DeathCell BodyCell Communication and SignalingCell SignalingCellsCerebral StrokeCerebrovascular ApoplexyCerebrovascular StrokeChildChild YouthChildren (0-21)ChromosomesClinical SkillsComplementComplement ProteinsDataDevelopmentDifferences between sexesDifferential Gene ExpressionDiffers between sexesDrugsDysfunctionEncephalonEndocrine Gland SecretionEngineeringEquilibriumExpression SignatureFemaleFoundationsFour Core GenotypesFunctional disorderFutureGene ExpressionGene Expression ProfileGenesGeneticGoalsGonadal HormonesGonosomesGrantHemato-Encephalic BarrierHistologyHistopathologyHormonesHortega cellImmuneImmune TargetingImmune responseImmunesInfiltrationInjuryIntracellular Communication and SignalingInvadedInvestigationIpsilateralLabelLearningLesionLiteratureLyonizationMacrophageMarrow monocyteMeasuresMedicationMentorsMiceMice MammalsMicrogliaModelingMurineMusMφNeonatalNeonatal Brain InjuryNeonatal asphyxia-induced brain injuryNeonatal hypoxic brain injuryNerve CellsNerve UnitNeural CellNeurocyteNeuroimmuneNeurologistNeuronsOutcomeOvaryPerinatal HypoxiaPerinatal Hypoxic-Ischemic EncephalopathyPerinatal anoxic ischemic brain injuryPharmaceutical PreparationsPhysiopathologyPlayPopulationResearchRoleSeveritiesSex ChromosomesSex DifferencesSexual differencesSignal TransductionSignal Transduction SystemsSignalingStrokeTesticlesTestingTestisTherapeutic HormoneTimeTissue-Specific Differential Gene ExpressionTissue-Specific Gene ExpressionTrainingTransgenic MiceTransplantationWorkX InactivationX-Chromosome InactivationXY femalesastrocytic gliabalancebalance functionbiological signal transductionbloodbrain barrierbrain attackbrain damagebrain damage in neonatesbrain injury in neonatesbrain-injuredcell typecerebral vascular accidentcerebrovascular accidentcomparing females and malescomparing women and mencomplementationdevelopmentaldifferential expressiondifferentially expresseddisabilitydrug/agentexperienceexperimentexperimental researchexperimental studyexperimentsfemales compared to malesfemales compared with malesfemales versus malesfemales vs. malesgene expression patterngene expression signaturegenetic approachgenetic strategygitter cellhost responsehypoxia/ischemiahypoxic ischemic encephalopathyimmune system responseimmunoresponseimproved outcomeinjuriesinjury responseischemic lesionkidsmalemembermesogliamicroglial cellmicrogliocytemonocyteneonatal HIEneonatal brain hypoxia-ischemianeonatal hypoxia-ischemianeonatal hypoxic-ischemic brain damageneonatal hypoxic-ischemic brain injuryneonatal hypoxic-ischemic encephalopathyneonateneuronalnew drug targetnew drug treatmentsnew druggable targetnew drugsnew pharmacological therapeuticnew pharmacotherapy targetnew therapeutic targetnew therapeuticsnew therapynew therapy targetnext generation therapeuticsnovel drug targetnovel drug treatmentsnovel druggable targetnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel pharmacotherapy targetnovel therapeutic targetnovel therapeuticsnovel therapynovel therapy targetpathophysiologyperipheral bloodperivascular glial cellpharmacologicpre-clinical studypreclinical studypreventpreventingresponseresponse to injurysexsex based differencessex-dependent differencessex-related differencessex-specific differencesskillssocial rolespatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicsstroke modelstrokedstrokestargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttooltranscriptional differencestranscriptional profiletranscriptional signaturetransplantwomen compared to menwomen compared with menwomen versus menwomen vs. menyoungster♀♂
Description preview
PROJECT SUMMARY
Perinatal hypoxic ischemic encephalopathy (HIE) is globally the second most common cause of
death and disability in neonates. Although the brain immune response contributes to the pathophysiology of
HIE, no current treatment targets the immune response. A major component of this immune response involves
macrophages, which have…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click