grant
Leveraging inter-individual differences in walking pain and impairment to elucidate whole-person mechanisms of knee osteoarthritis
Organization UNIVERSITY OF PITTSBURGH AT PITTSBURGHLocation PITTSBURGH, UNITED STATESPosted 19 Sept 2025Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY2025Absence of pain sensationAbsence of sensibility to painAffectAgeAnalgesia TestsAnxietyBMIBMI percentileBMI z-scoreBiologic FactorBiological FactorsBiomechanicsBody SystemBody mass indexBrainBrain Nervous SystemBrain imagingClinicalComplexDataData CollectionData SetDegenerative ArthritisDegenerative polyarthritisDimensionsDiseaseDisorderEncephalonEnvironmentEvaluationExerciseFeels no painFunctional impairmentFundingGaitGait speedGoalsHEAL InitiativeHealthHelping End Addiction Long-termHelping to End Addiction Long-termHeterogeneityImmobilizationImpairmentIndividualIndividual DifferencesInvestigatorsJointsKneeKnee InjuriesKnee OsteoarthritisKnee jointLinear RegressionsLiteratureLoad BearingLogistic RegressionsMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMeasuresMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMental DepressionMissionModelingMorbidityMorbidity - disease rateMovementNMR ImagingNMR TomographyNational Institutes of HealthNervous SystemNeurologic Body SystemNeurologic Organ SystemNo sensitivity to painNociception TestsNuclear Magnetic Resonance ImagingObservation researchObservation studyObservational StudyObservational researchOrgan SystemOsteoarthritisOsteoarthrosisOutcomePainPain AssessmentPain ControlPain MeasurementPain TherapyPain interferencePain managementPain measurePain qualityPainfulParticipantPatientsPatternPerformancePersonal SatisfactionPersonsPhysiatric ProcedurePhysical Medicine ProcedurePhysical TherapeuticsPhysical activityPhysical therapyPhysiotherapyPlayPopulationPredictive FactorPredispositionProbabilistic ModelsProbability ModelsProcessPsychological FactorsQOL improvementQuestionnairesQuetelet indexResearchResearch PersonnelResearchersRoleSamplingSeasonsSelf AssessmentSensorySleep disturbancesStatistical ModelsStructureSusceptibilityTestingTherapeuticTimeUnited StatesUnited States National Institutes of HealthVariantVariationVisitWalkingWeight BearingWeight-Bearing stateZeugmatographyaberrant sleepadvanced analyticsagesanalgesiabiomechanicalbiomechanical analysesbiomechanical analysisbiomechanical assessmentbiomechanical characterizationbiomechanical evaluationbiomechanical measurementbiomechanical profilingbiomechanical testbiopsychosocialbiopsychosocial factorbiopsychosocial variablebody movementbrain visualizationclinical relevanceclinically relevantco-morbidco-morbiditycomorbidityconditioned pain modulationdegenerative joint diseasedepressiondisabilitydisrupted sleepdisturbed sleepexpectationexperiencefNIRSfallsfunctional improvementfunctional near infrared spectroscopyhypertrophic arthritisimpaired sleepimprove functionimprovedimproved functional outcomesimprovements in QOLimprovements in quality of lifeindividual heterogeneityindividual variabilityindividual variationinter-individual variabilityinter-individual variationirregular sleepknee OAknee joint OAknee joint osteoarthritisknee painmachine learning based methodmachine learning methodmachine learning methodologiesmeetingmeetingsmortalitymultidisciplinarynegative affectnegative affectivityneuralnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetorthopedic freezingpain assaypain interventionpain reductionpain scorepain treatmentpatient subclasspatient subclusterpatient subgroupspatient subpopulationspatient subsetspatient subtypesperformance in walkingpersonalization of treatmentpersonalized medicinepersonalized therapypersonalized treatmentpreventpreventingprimary outcomepsychosocialquality of life improvementreduce painsleep disruptionsleep dysregulationsleep/wake disruptionsleep/wake disturbancesocial engagementsocial factorssocial involvementsocial participationsocial rolestatistical linear mixed modelsstatistical linear modelswalking performancewell-beingwellbeingyears lived with disability
Description preview
Project Summary/Abstract
Knee osteoarthritis (OA) is a common and debilitating condition, affecting millions in the United States of America.
From 1990 to 2020, OA ranked as the 14th highest cause of age-adjusted years lived with disability and is a
serious disease due to disability, which increases mortality. Although the impact of knee OA on the…
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