grant
Leveraging in vivo protein tracking to identify novel immune markers associated with obesity driven disease
Organization SCRIPPS RESEARCH INSTITUTE, THELocation LA JOLLA, UNITED STATESPosted 16 May 2025Deadline 15 May 2028
NIHUS FederalResearch GrantFY2025Acylcholesterol LipaseAdenosine Cyclic Monophosphate-Dependent Protein KinasesAdipocytesAdipose CellAdipose tissueAdult-Onset Diabetes MellitusAffectAffinityAssayAttenuatedAutomobile DrivingB blood cellsB cellB cellsB-CellsB-LymphocytesB-cellBioassayBiologicalBiological AssayBiological MarkersBiotinBiotinylationBlood VesselsBody TissuesBody Weights and MeasuresBrown Adipose TissueBrown FatCancersCardiovascular DiseasesCell BodyCell Communication and SignalingCell FunctionCell IsolationCell LocomotionCell MigrationCell Migration AssayCell MovementCell PhysiologyCell ProcessCell SegregationCell SeparationCell Separation TechnologyCell SignalingCell surfaceCellsCellular FunctionCellular MigrationCellular MotilityCellular PhysiologyCellular ProcessCholesterolCholesterol Ester HydrolaseCholesterol EsteraseCholesteryl Oleate HydrolaseCholesterylester HydrolaseCo-ImmunoprecipitationsCo-cultureCocultivationCocultureCoculture TechniquesCollaborationsCommunicationConsumptionCyclic AMP-Dependent Protein KinasesD-GlucoseDendritic CellsDestinationsDevelopmentDextroseDietDifferentation MarkersDifferentiation AntigensDifferentiation MarkersDiseaseDisorderDistalDysfunctionELISAEndocrine Gland SecretionEndoplasmic ReticulumEngineeringEnzyme-Linked Immunosorbent AssayEpidemicEpithelial CellsErgastoplasmFamilyFastingFat CellsFatsFatty TissueFatty acid glycerol estersFructoseFunctional disorderFundingFutureGWA studyGWASGene variantGlucoseGrantHarvestHealthHepatic DisorderHibernating GlandHormone-Sensitive LipaseHormonesHuman GeneticsHumulin RImmuneImmune MarkersImmune responseImmunesImmunologic MarkersIn VitroIndividualInflammasomeInflammationInflammatoryInsulinIntakeIntermediary MetabolismIntestinalIntestinal SecretionsIntestinesIntracellular Communication and SignalingInvestigationInvestigatorsKO miceKetosis-Resistant Diabetes MellitusKnock-out MiceKnockout MiceLabelLeadLeannessLevuloseLigaseLigase GeneLipidsLipocytesLipoidal Steroid EsteraseLipolysisLiver diseasesMacrophageMagnetismMalignant NeoplasmsMalignant TumorMarker AntigensMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMature LipocyteMature fat cellMaturity-Onset Diabetes MellitusMeasuresMedicalMetabolic DiseasesMetabolic DisorderMetabolic PathwayMetabolic ProcessesMetabolismMethodsMiceMice MammalsMicroscopyMigration AssayMonomeric G-ProteinsMonomeric GTP-Binding ProteinsMurineMusMφNIDDMNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusNovolin RNull MouseNutrientObesityOrganPKAPancreasPancreaticPathway interactionsPb elementPhenotypePhosphoprotein PhosphatasePhosphoprotein Phosphatase-2CPhosphoprotein PhosphohydrolasePhysiologyPhysiopathologyPlayPopulationProliferatingProtein FamilyProtein Kinase AProtein Phosphatase CProtein Phosphatase GeneProtein Phosphatase-1Protein Phosphatase-2AProtein SecretionProtein phosphataseProteinsProteomicsQuantitative RTPCRQuantitative Reverse Transcriptase PCRRNA SeqRNA sequencingRNAseqReceptor ProteinRegular InsulinResearch PersonnelResearchersRoleSignal TransductionSignal Transduction SystemsSignalingSkeletal MuscleSlow-Onset Diabetes MellitusSmall G-ProteinsSmall GTPasesSortingStable Diabetes MellitusSteroid Hormone EsteraseSterol Ester AcylhydrolaseSteryl-ester acylhydrolaseStrepavidinStreptavidinSubcellular ProcessSupervisionSynthetasesSystemT-CellsT-LymphocyteT2 DMT2DT2DMTherapeutic HormoneThesaurismosisThinnessTissuesToxinTrainingTransmissionType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesVeiled CellsVitamin HVoluntary MuscleWild Type MouseXenopus B2 antigenadiposeadiposityadult onset diabetesallelic variantattenuateattenuatesbio-markersbiochemical toolsbiochemistry toolsbiologicbiologic markerbiological signal transductionbiomarkerbowelcAMP-Dependent Protein Kinasescardiovascular disordercell motilitycell sortingcholesteryl ester synthasecoenzyme Rcombatconditional knock-outconditional knockoutcorpulencecytokinedevelopmentaldietsdrivingdruggable targetdysbacteriosisdysbiosisdysbioticenzyme linked immunoassayfastedfastsfat metabolismfeedinggain of functiongastrointestinal symptomgenetic variantgenome wide associationgenome wide association scangenome wide association studygenomewide association scangenomewide association studygenomic variantglucagon like peptideglucagon-like peptideheavy metal Pbheavy metal leadhepatic diseasehepatopathyhost responseimmune system responseimmune-based biomarkersimmunological biomarkersimmunological markersimmunoresponsein vivoin vivo Modelinduced Creinducible Creinsightinsulin sensitivityintestinal epitheliumketosis resistant diabeteslipid metabolismliver disordermagneticmalignancymaturity onset diabetesmetabolism disordermicrobial imbalancemigrationmouse modelmultidisciplinarymurine modelneoplasm/cancernovelobesity developmentoverexpressoverexpressionpathophysiologypathwayplexinqRTPCRreceptorresponsesocial rolesterol esterasesubcutaneoussubdermaltargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmentthymus derived lymphocytetooltranscriptome sequencingtranscriptomic sequencingtransmission processtriterpenol esterasetype 2 DMtype II DMtype two diabetesuptakevascularwhite adipose tissuewhole genome association analysiswhole genome association studywildtype mouseyellow adipose tissue
Description preview
PROJECT SUMMARY.
To date, biochemical tools to study secreted proteins’ origins and destinations leading to the discovery of new
biomarkers associated with disease are underdeveloped. Deciphering interorgan communication pathways will
provide insights into key modulators of obesity driven inflammation. Interorgan dysfunction from
overconsumption,…
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