grant
Leveraging human organoid models for the development of broad interventions to mitigate emergent respiratory viral pandemics
Organization STANFORD UNIVERSITYLocation STANFORD, UNITED STATESPosted 1 Sept 2003Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY20250-11 years old2019 novel corona virus2019 novel coronavirus2019-nCoV2019-nCoV S protein2019-nCoV spike glycoprotein2019-nCoV spike protein2019-nCoV vaccine21+ years old3-D structure3-dimensional structure3D structure7S Gamma GlobulinAb-mediated immunityAb-mediated protectionAdultAdult HumanAffinityAntibodiesAntibody ResponseAntibody immunityAntibody protectionAntibody-mediated protectionAntigen-Antibody ComplexAntigenic DeterminantsAntigensB blood cellsB cellB cellsB-CellsB-LymphocytesB-cellBindingBinding DeterminantsBiochemicalBioinformaticsBiologic ModelsBiological ModelsBlood PlasmaCOVID-19COVID-19 S proteinCOVID-19 antibodyCOVID-19 spikeCOVID-19 spike glycoproteinCOVID-19 spike proteinCOVID-19 vaccinationCOVID-19 vaccineCOVID-19 virusCOVID19 virusCV-19Canine SpeciesCanis familiarisChildChild YouthChildren (0-21)Clinical Treatment MoabCoV-2CoV2CollaborationsComplementComplement ProteinsComplexCoronaviridaeCoronaviridae InfectionsCoronavirusCoronavirus InfectionsCoronavirus Infectious Disease 2019Cryo-electron MicroscopyCryoelectron MicroscopyDevelopmentDiabetes MellitusDirected Molecular EvolutionDogsDogs MammalsEffectivenessEffector CellElectron CryomicroscopyElectron MicroscopyEngineeringEpidemicEpitope MappingEpitopesEvaluationEventFOXP3FOXP3 geneFamily suidaeFeedbackForkhead Box P3FutureGenerationsGeneticGerm LinesGerminal CenterGrippeHCoVHaitianHealthHemagglutininHost FactorHost Factor ProteinHumanHuman MetapneumovirusHumoral ImmunitiesIgGImmuneImmune ComplexImmune mediated therapyImmune responseImmune systemImmunesImmunityImmunizationImmunoglobulin GImmunologically Directed TherapyImmunologyImmunotherapyIn VitroInfectionInfluenzaInfluenza AInfluenza A virusInfluenza HAInfluenza HemagglutininInfluenza Viruses Type AInfluenzavirus AIntegration Host FactorsInterventionJM2LungLung Respiratory SystemMeasuresMemory B CellMemory B-LymphocyteModel SystemModelingModern ManMolecularMolecular InteractionMonoclonal AntibodiesMorbidityMorbidity - disease rateNegative StainingObesityOrganoidsOrthocoronavirinaeOrthomyxovirus Type APBMCPeripheral Blood Mononuclear CellPigsPlasmaPlasma SerumPopulationProbabilityProtein EngineeringRNA VirusesResolutionReticuloendothelial System, Serum, PlasmaRiskRisk FactorsRoleSARS corona virus 2SARS-CO-V2SARS-COVID-2SARS-CoV-2SARS-CoV-2 SSARS-CoV-2 S proteinSARS-CoV-2 antibodySARS-CoV-2 spikeSARS-CoV-2 spike glycoproteinSARS-CoV-2 spike proteinSARS-CoV-2 vaccinationSARS-CoV-2 vaccineSARS-CoV2SARS-associated corona virus 2SARS-associated coronavirus 2SARS-coronavirus-2SARS-coronavirus-2 vaccineSARS-related corona virus 2SARS-related coronavirus 2SARSCoV2SCURFINSarbecovirusSeasonsSevere Acute Respiratory Coronavirus 2Severe Acute Respiratory Distress Syndrome CoV 2Severe Acute Respiratory Distress Syndrome Corona Virus 2Severe Acute Respiratory Distress Syndrome Coronavirus 2Severe Acute Respiratory Syndrome CoV 2Severe Acute Respiratory Syndrome CoV 2 vaccineSevere Acute Respiratory Syndrome-associated coronavirus 2Severe Acute Respiratory Syndrome-related coronavirus 2Severe acute respiratory syndrome associated corona virus 2Severe acute respiratory syndrome coronavirus 2Severe acute respiratory syndrome coronavirus 2 S proteinSevere acute respiratory syndrome coronavirus 2 spike glycoproteinSevere acute respiratory syndrome coronavirus 2 spike proteinSevere acute respiratory syndrome coronavirus 2 vaccinationSevere acute respiratory syndrome coronavirus 2 vaccineSevere acute respiratory syndrome related corona virus 2SiteSpecificitySpeedSpleenSpleen Reticuloendothelial SystemStructureStructure of germinal center of lymph nodeSubunit VaccinesSuidaeSwineSymptomsT cell responseT-CellsT-LymphocyteTechniquesTechnologyTestingTransmissionType A InfluenzaVaccinatedVaccinationVaccineeVaccinesVariantVariationViralViral DiseasesVirusVirus DiseasesVirus ReplicationWorkWuhan coronavirusZoonosesZoonoticZoonotic Infectionadaptive immune responseadiposityadulthoodantibody against COVID-19antibody against SARS-CoV-2antibody against coronavirus disease 2019antibody against severe acute respiratory syndrome coronavirus 2antibody to COVID-19antibody to SARS-CoV-2antibody to coronavirus disease 2019antibody to severe acute respiratory syndrome coronavirus 2antibody-based immunityantibody-mediated immunitycaninecomplementationcorona viruscoronavirus disease 2019coronavirus disease 2019 S proteincoronavirus disease 2019 antibodycoronavirus disease 2019 spike glycoproteincoronavirus disease 2019 spike proteincoronavirus disease 2019 vaccinationcoronavirus disease 2019 vaccinecoronavirus disease 2019 viruscoronavirus disease-19coronavirus disease-19 vaccinecoronavirus disease-19 viruscoronavirus infectious disease-19coronavirus vaccinecorpulencecross reactivitycryo-EMcryoEMcryogenic electron microscopydesigndesigningdevelopmentaldiabetesdirected evolutiondomestic dogelectron crystallographyemergent pandemicemerging pandemicfluflu HAflu hemagglutiningenetic protein engineeringhCoV19host responsehuman CoVhuman corona virushuman coronavirushuman diseaseimmune system responseimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmunization strategyimmuno therapyimmunogenimmunoresponseimprintin vivoinfluenza viral HAinfluenza viral hemagglutinininfluenza virus HAinfluenza virus hemagglutinininnovateinnovationinnovativeinsightkidsmAbsmembermonoclonal AbsmortalitynCoV vaccinenCoV-19 vaccinenCoV19 vaccinenCoV2nano particlenano-sized particlenanoparticlenanosized particleneutralizing antibodynew pandemicnovel pandemicpandemicpandemic concernpandemic containmentpandemic controlpandemic diseasepandemic mitigationpandemic potentialpandemic responsepandemic riskpandemic threatparticleporcineprotein designreceptor bindingreceptor boundresolutionsrespiratoryrespiratory virusresponseseasonal fluseasonal influenzasevere acute respiratory syndrome coronavirus 2 antibodysocial rolespike proteins on SARS-CoV-2spillover eventstructural biologysuidsynergismthree dimensional structurethymus derived lymphocytetransmission processvaccinate against COVID-19vaccinate against SARS-CoV-2vaccinate against coronavirus disease 2019vaccinate against severe acute respiratory syndrome coronavirus 2vaccinated individualvaccinated participantvaccinated patientvaccinated personvaccinated subjectvaccination against COVID-19vaccination against SARS-CoV-2vaccination against Severe acute respiratory syndrome coronavirus 2vaccination against coronavirus disease 2019vaccination strategyvaccine against 2019-nCovvaccine against COVID-19vaccine against SARS-CoV-2vaccine against SARS-coronavirus-2vaccine against Severe Acute Respiratory Syndrome CoV 2vaccine against Severe acute respiratory syndrome coronavirus 2vaccine against coronavirusvaccine candidate against coronavirusvaccine candidates against SARS-CoV-2vaccine for novel coronavirusvaccine platformvaccine responsevaccine responsivenessvaccine-induced responsevaccines preventing COVIDvaccines to prevent COVIDviral epidemicviral infectionviral multiplicationviral pandemicviral replicationvirus infectionvirus multiplicationvirus-induced diseaseweaponsyoungsterzoonotic CoVzoonotic coronaviruszoonotic spillover
Description preview
PROJECT SUMMARY
Human respiratory viruses not only contribute to substantial morbidity and mortality worldwide but also pose
a massive pandemic threat. This broad range of viruses includes human coronavirus (hCoVs), influenza A,
and human metapneumoviruses (HMPV). Vaccines are among the most powerful means for mitigating viral
epidemics but…
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