grant
Left-Right Organizer Cellular and Molecular Dynamics Drive Early Cardiac Asymmetries
NIHUS FederalResearch GrantFY2025AffectAntibodiesBasic ResearchBasic ScienceBrachydanio rerioCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCalcium Ion SignalingCalcium SignalingCardiacCardiac MalformationCardiac developmentCas nuclease technologyCausalityCell BodyCell Communication and SignalingCell DifferentiationCell Differentiation processCell SignalingCellsCellular MechanotransductionCiliaClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCommunicationComplex thinkingCritical ThinkingCrownsCustomDNA mutationDanio rerioDataData SetDefectDevelopmentDevelopmental BiologyEmbryoEmbryo DevelopmentEmbryogenesisEmbryologic StructureEmbryonicEmbryonic DevelopmentEmbryonic StructuresEtiologyEvaluative ThinkingEventFellowshipFutureGastrulaGene ExpressionGene TranscriptionGenerationsGenesGeneticGenetic ChangeGenetic TranscriptionGenetic defectGenetic mutationGenetic studyGenetics-MutagenesisGerm LayersGoalsHandednessHeartHeart MalformationHeterogeneityHumanImage AnalysesImage AnalysisImmunofluorescenceImmunofluorescence ImmunologicIn Situ HybridizationInfantIntracellular Communication and SignalingInvestigatorsKnowledgeLateralityLeftMMPsMatrix MetalloproteinasesMechanical Signal TransductionMechanosensory TransductionMentorsMessenger RNAMetallopeptidasesMetalloproteasesMetalloproteinasesMiceMice MammalsModelingModern ManMolecular Dynamics SimulationMorphogenesisMorphologyMotilityMurineMusMutagenesisMutagenesis Molecular BiologyMutant Strains MiceMutationOrganPatternPopulationPredispositionProtein SecretionProteinsRNA ExpressionReactionResearchResearch DesignResearch PersonnelResearchersRoleSideSignal TransductionSignal Transduction SystemsSignalingSiteStructureStudy TypeSurvival RateSusceptibilityTestingTimeTrainingTranscriptTranscriptionTranslational ResearchTranslational ScienceValidationVisceralWild Type MouseWorkZebra DanioZebra FishZebrafishabnormal heart developmentbiological signal transductionbiomarker identificationcardiogenesiscareercausationcell typecellular differentiationcilium motilitycongenital cardiac abnormalitycongenital cardiac anomaliescongenital cardiac diseasecongenital cardiac disordercongenital cardiac malformationcongenital heart abnormalitycongenital heart anomalycongenital heart diseasecongenital heart disordercongenital heart malformationcustomsdevelopmentaldifferential expressiondifferentially expresseddisease causationexperimentexperimental researchexperimental studyexperimentsgene nullgene panelgenome mutationgenomic datagenomic datasetheart developmentheart formationidentification of biomarkersidentification of new biomarkersimage evaluationimage interpretationin situ Hybridization Geneticsin situ Hybridization Staining Methodin vivoinsightmRNAmarker identificationmechanosensingmechanotransductionmicroscope imagingmicroscopic imagingmicroscopy imagingmolecular dynamicsmorphogenetic processmouse geneticsmouse mutantmultigene panelmutantnull mutationscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingskillssocial rolespatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicsstudy designtranscriptional differencestranscriptomicstranslation researchtranslational investigationvalidationsvertebrate embryoswildtype mouse
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PROJECT SUMMARY/ABSTRACT
Abnormal development of the left-right (LR) axis during embryogenesis can manifest as a broad spectrum
of severe congenital heart diseases (CHDs), a group of conditions that affects 1% of all infants and in which
the cardiac structure is disrupted. The LR axis is established at the Left-Right Organizer (LRO), a transient…
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