grant
LEAD OPTIMIZATION OF A LONG NON-CODING RNA (LNCRNA) AS A POTENTIAL LIPID- AND GLUCOSE-LOWERING THERAPEUTIC
Organization LEIDOS BIOMEDICAL RESEARCH, INC.Location FREDERICK, UNITED STATESPosted 15 Sept 2025Deadline 14 Sept 2030
NIHUS FederalResearch GrantFY2025ContractorD-GlucoseDextroseFunctional RNAGlucoseLeadLipidsNon-Polyadenylated RNANoncoding RNANontranslated RNAPb elementRNARNA Gene ProductsRibonucleic AcidTherapeuticToxic effectToxicitiesUntranslated RNAassay developmentefficacy studyheavy metal Pbheavy metal leadin vivolead optimizationnoncodingsafety assessment
Description preview
The contractor(s) will be responsible to perform synthesis of lead RNA candidates, conducting potency
assay development to optimize and downslect RNA leads, to conduct exploratory toxicity studies and
DMPK to assess the safety of the leads, and in vivo efficacy studies as a go/no go miletone.
Grant Number: 75N91019D00024-0-759102500019-1
NIH…
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