grant
Laboratory of Genetic Susceptibility
Organization DIVISION OF CANCER EPIDEMIOLOGY AND GENETICSLocation UNITED STATES
NIHUS FederalResearch GrantFY2025Active Follow-upAffectAgeBioinformaticsBiologicalBiologyCancersCausalityCell Communication and SignalingCell LineCell SignalingCellLineChromosomal FragilityChromosome FragilityClinical ResearchClinical StudyCollaborationsConsultDCEGDNA mutationDataData PoolingData SetDiathesisDiseaseDisease susceptibilityDisorderDivision of Cancer Epidemiology and GeneticsElementsEpidemiologic ResearchEpidemiologic StudiesEpidemiological StudiesEpidemiologistEpidemiologyEpidemiology ResearchEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEtiologyEventFamilyGTExGWA studyGWASGene AlterationGene MutationGene variantGene x Environment InteractionGenesGeneticGenetic ChangeGenetic PolymorphismGenetic PredispositionGenetic Predisposition to DiseaseGenetic SusceptibilityGenetic defectGenetic mutationGenetic propensityGenetic studyGenomeGenomicsGenotype-Tissue Expression ProjectGerm LinesGroups at riskGxE interactionHaplotypesHealthHereditaryHumanHuman GenomeIndividualInheritedInherited PredispositionInherited SusceptibilityInterdisciplinary ResearchInterdisciplinary StudyInternationalIntracellular Communication and SignalingInvestigationInvestigatorsLaboratoriesLaboratory ResearchMaintenanceMalignant NeoplasmsMalignant TumorMethodological StudiesMicroRNAsModelingModern ManMolecularMolecular EpidemiologyMolecular EvolutionMosaicismMultidisciplinary CollaborationMultidisciplinary ResearchMutationNormal TissueNormal tissue morphologyOutcomePathway interactionsPeople at riskPersons at riskPhenotypePopulation GeneticsPopulation StudyPopulations at RiskPredictive ValuePredispositionPredisposition geneRegulatory ElementResearchResearch PersonnelResearch ResourcesResearchersResourcesRiskRisk FactorsScientistSeriesSignal TransductionSignal Transduction SystemsSignalingSingle Base PolymorphismSingle Nucleotide PolymorphismSiteSomatic MutationStrains Cell LinesSusceptibilitySusceptibility GeneTCGAThe Cancer Genome AtlasTherapeutic InterventionTimeTranscriptTumor TissueUniparental DisomyVariantVariationactive followupagesallelic variantbiologicbiological signal transductioncancer genomicscancer heterogeneitycancer riskcancer sub-typescancer subtypescausationcohortconsultscultured cell linedeep sequencingdesigndesigningdisease causationenvironment effect on geneepidemiologicepidemiologic investigationepidemiologicalepidemiology studyepigeneticallyfollow upfollow-upfollowed upfollowupgene defectgene environment interactiongenetic analysisgenetic architecturegenetic epidemiologic studygenetic epidemiologygenetic etiologygenetic mechanism of diseasegenetic variantgenetic vulnerabilitygenetically predisposedgenome mutationgenome scalegenome wide associationgenome wide association scangenome wide association studygenome-widegenomewidegenomewide association scangenomewide association studygenomic varianthigh riskhuman whole genomeinsightinterdisciplinary approachintervention therapylarge scale datalarge scale data setslarge scale datasetsliability to diseasemalignancymethylation patternmiRNAmosaicmosaic diseasesmosaic disordersmultidisciplinary approachmutant alleleneoplasm/cancernoveloncogenomicspathwaypolymorphismpopulation-based studypopulation-level studypredisposing genepublic data basepublic databasepublicly accessible data basepublicly accessible databasepublicly available data basepublicly available databasesingle nucleotide variantsomatic variantstudies of populationsstudy of the populationsusceptibility allelesusceptibility locussusceptibility varianttumorvalidation studieswhole genome association analysiswhole genome association study
Description preview
The Laboratory of Genomic Susceptibility (LGS) in the Division of Cancer Epidemiology and Genetics (DCEG) is committed to understanding the biological basis for genetic susceptibility to cancer, including identification and characterization of cancer susceptibility alleles, characterization of the scope of genetic mosaicism and its contribution to…
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