grant
Labeling cellular proteins for multi-scale microscopy and other applications
Organization OREGON HEALTH & SCIENCE UNIVERSITYLocation PORTLAND, UNITED STATESPosted 18 Sept 2023Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY2025AffinityAntibody SpecificityBindingBiologyCD71ChemicalsColorComputer AnalysisDNA mutationDimensionsDimerizationDiseaseDisorderDrugsElectron MicroscopyElectronsFe elementFluorescence Light MicroscopyFluorescence MicroscopyFundingGeneticGenetic ChangeGenetic defectGenetic mutationImageInvestigatorsIronLabelMedicationMethodsMicroscopeMicroscopyMissionMolecularMolecular InteractionMutationNIGMSNamesNational Institute of General Medical SciencesNational Institutes of HealthNegative Beta ParticleNegatronsOrganismPeptidesPharmaceutical PreparationsProtein DimerizationProteinsReceptor ProteinReporterResearchResearch PersonnelResearchersTFR geneTFR proteinTFR1TFRCTFRC geneTRFRTechnologyTfR2 gene productTimeTransferrin ReceptorTransferrin Receptor 1Transferrin Receptor Protein 2United States National Institutes of HealthWhole OrganismWorkbiocompatibilitybiomaterial compatibilitycatalystcomputational analysescomputational analysiscomputer analysesdesigndesigningdrug/agentfacilities for imagingfluorophoregenome mutationhigh resolution imagingimagingimaging centerimaging facilitiesimaging studyimaging-related facilitiesinnovateinnovationinnovativeinnovative technologiesinstrumentationlight microscopyliving systemnamenamednamingnano particlenano-sized particlenanoparticlenanosized particlenew technologynovelnovel technologiesprogramsprotein functionprotein structureprotein structuresproteins structurereceptorsensorsingle moleculesmall moleculetech developmenttechnology developmenttraffickingtransferrin receptor 2uptakeuser-friendly
Description preview
Abstract
The Beatty group's research program is investigating how cellular proteins organize and interact in space
and time. We use the principles of chemical biology to create new technologies for labeling and imaging
proteins with an innovative set of reporters.
Recent advances in imaging instrumentation and computational analysis have created…
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